Search Results - "McReynolds, Katherine D."
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Sulfoglycodendron Antivirals with Scalable Architectures and Activities
Published in Journal of chemical information and modeling (23-09-2024)“…Many viruses initiate their cell-entry by binding their multisubunit receptors to human heparan sulfate proteoglycans (HSPG) and other molecular components…”
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Retrained Generic Antibodies Can Recognize SARS-CoV‑2
Published in The journal of physical chemistry letters (11-02-2021)“…The dramatic impact novel viruses can have on humans could be more quickly mitigated if generic antibodies already present in one’s system are temporarily…”
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Synthesis and Nuclear Magnetic Resonance Structural Evaluation of Oxime-Linked Oligosialic Acid-Based Glycodendrimers
Published in Biomacromolecules (10-04-2023)“…A series of four oxime-linked octavalent sialic acid and oligosialic acid poly(ether amidoamine) glycodendrimers were synthesized. In the attachment of the…”
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Synthesis of hydrophilic aminooxy linkers and multivalent cores for chemoselective aldehyde/ketone conjugation
Published in Tetrahedron letters (02-04-2014)“…A series of three linear and two trivalent aminooxy-containing hydrophilic linkers and cores were synthesized. The five molecules contain from one to three…”
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Chemotherapeutic Interventions Targeting HIV Interactions with Host-Associated Carbohydrates
Published in Chemical reviews (01-05-2007)“…The elucidation of the roles of carbohydrates in HIV infections and transport can lead to new chemotherapy treatments. Specific interactions between HIV-env…”
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Evaluation of the Synthesis of Sialic Acid-PAMAM Glycodendrimers without the Use of Sugar Protecting Groups, and the Anti-HIV-1 Properties of These Compounds
Published in Bioconjugate chemistry (19-10-2011)“…A study was undertaken to evaluate the feasibility of synthesizing six sialic acid-PAMAM glycodendrimers using unprotected sialic acid in as few as 1–4 steps…”
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Quantitative Measurements of Recombinant HIV Surface Glycoprotein 120 Binding to Several Glycosphingolipids Expressed in Planar Supported Lipid Bilayers
Published in Journal of the American Chemical Society (13-02-2002)“…The interaction of recombinant HIV-1 surface glycoprotein gp120 (rgp120) with natural isolates of lactosylceramide (LacCer), glucosylceramide (GlcCer), and…”
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An Efficient Microwave-Mediated Synthesis of Hexavalent Sialic Acid Sulfoglycodendrimers as Potential Anti-HIV Agents
Published in ACS applied polymer materials (13-11-2020)“…A series of four sialic acid-containing hexavalent sulfoglycodendrimers (SGDs) were synthesized in excellent yields using an efficient strategy involving…”
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Examining the secondary structures of unnatural peptides and carbohydrate-based compounds utilizing circular dichroism
Published in Tetrahedron: asymmetry (11-02-2000)“…This review focuses on the use of CD in elucidating structure in oligo- and polysaccharides, unnatural β- and γ-peptides, and both natural and unnatural oligo-…”
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Sulfoglycodendrimer Therapeutics for HIV‐1 and SARS‐CoV‐2
Published in Advanced therapeutics (01-04-2021)“…Hexavalent sulfoglycodendrimers (SGDs) are synthesized as mimics of host cell heparan sulfate proteoglycans (HSPGs) to inhibit the early stages in viral…”
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Glycobiology, how to sugar‐coat an undergraduate advanced biochemistry laboratory
Published in Biochemistry and molecular biology education (01-09-2006)“…A second semester biochemistry laboratory has been implemented as an independent projects course at California State University, Sacramento since 1999. To…”
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Synthesis of Biotinylated Glycoconjugates and Their Use in a Novel ELISA for Direct Comparison of HIV-1 Gp120 Recognition of GalCer and Related Carbohydrate Analogues
Published in Bioconjugate chemistry (01-11-1999)“…As part of our program directed toward the design and synthesis of high-affinity ligands for the GalCer-binding site on the HIV cell surface glycoprotein,…”
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Non-Natural glycosphingolipids and structurally simpler analogues bind HIV-1 recombinant Gp120
Published in Bioorganic & medicinal chemistry (01-03-2002)“…Interactions of recombinant gp120 (rgp120) with non-natural glycosphingolipids (GSLs) and structurally simpler analogues have been studied using a competitive…”
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Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium by Total Internal Reflection Fluorescence Microscopy
Published in Angewandte Chemie International Edition (18-08-2000)“…The binding of the HIV‐1 surface glycoprotein gp120 to several glycosphingolipids, reconstituted into planar lipid bilayers (see scheme; small circle=…”
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Solid Phase Synthesis and Secondary Structural Studies of (1→5) Amide-Linked Sialooligomers1
Published in Journal of organic chemistry (20-02-1998)“…A series of dimeric through octameric (1→5) amide-linked sialooligomers were prepared using solid-phase peptide methods on Rink resin with Fmoc protecting…”
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Solid Phase Synthesis and Secondary Structural Studies of (1→5) Amide-Linked Sialooligomers 1
Published in Journal of organic chemistry (01-02-1998)Get full text
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Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium by Total Internal Reflection Fluorescence Microscopy
Published in Angewandte Chemie (18-08-2000)“…Die Bindung des Oberflächen‐Glycoproteins von HIV‐1, gp120, an mehrere Glycosphingolipide, angeordnet in Lipiddoppelschichten (siehe Bild; kleine…”
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