Search Results - "McRae, Bradford"

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells by Woznicki, Jerzy A., Saini, Nisha, Flood, Peter, Rajaram, Subhasree, Lee, Ciaran M., Stamou, Panagiota, Skowyra, Agnieszka, Bustamante-Garrido, Milan, Regazzoni, Karine, Crawford, Nyree, McDade, Simon S., Longley, Daniel B., Aza-Blanc, Pedro, Shanahan, Fergus, Zulquernain, Syed A., McCarthy, Jane, Melgar, Silvia, McRae, Bradford L., Nally, Ken

“…Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and…”
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Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus by Perper, Stuart J, Westmoreland, Susan V, Karman, Jozsef, Twomey, Rachel, Seagal, Jane, Wang, Rui, McRae, Bradford L, Clarke, Stephen H

“…CD40 is a costimulatory receptor on APCs that is critical for the induction and maintenance of humoral and cell-mediated immunity. Accordingly, CD40 and its…”
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DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids by Flood, Peter, Fanning, Aine, Woznicki, Jerzy A, Crowley, Tadhg, Christopher, Andrea, Vaccaro, Alessandra, Houston, Aileen, McSweeney, Sheila, Ross, Sarah, Hogan, Aileen, Brint, Elizabeth, Skowyra, Agnieszka, Bustamante, Milan, Ambrose, Monica, Moloney, Gerard, MacSharry, John, Hammarström, Marie-Louise, Hurley, Margot, Fitzgibbons, Christine, Quigley, Eamonn M M, Shanahan, Fergus, Zulquernain, Syed A, McCarthy, Jane, Dodson, G Steven, Dabbagh, Karim, McRae, Bradford L, Melgar, Silvia, Nally, Ken

“…DNA sensor pathways can initiate inflammasome, cell death, and type I interferon (IFN) signaling in immune-mediated inflammatory diseases (IMIDs), including…”
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Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease by Zhu, Qifan, Korenfeld, Daniel, Suarez-Fueyo, Abel, Graham, Sean, Jin, Liang, Punit, Shivesh, Duffy, Rachael, Puri, Munish, Caruso, Andrew, Hu, Chenqi, Tian, Yu, McRae, Bradford L., Kamath, Raj, Phillips, Lucy, Schwartz-Sterman, Annette J., Westmoreland, Susan, Cao, Xiaohong, Levesque, Marc C., Bi, Yingtao, Paez-Cortez, Jesus, Goenka, Radhika

“…Inflammatory bowel disease (IBD) is characterized by a dysregulated intestinal epithelial barrier leading to breach of barrier immunity. Here we identified…”
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Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models by Zhang, Liang, Wallace, Craig D., Erickson, Jamie E., Nelson, Christine M., Gaudette, Stephanie M., Pohl, Calvin S., Karsen, Samuel D., Simler, Gricelda H., Peng, Ruoqi, Stedman, Christopher A., Laroux, F. Stephen, Wurbel, Marc A., Kamath, Rajesh V., McRae, Bradford L., Schwartz Sterman, Annette J., Mitra, Soumya

“…Intestinal permeability and neutrophil activity are closely linked to inflammatory bowel disease (IBD) pathophysiology. Here we discuss two techniques for…”
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Anti–Tumor Necrosis Factor With a Glyco-Engineered Fc-Region Has Increased Efficacy in Mice With Colitis by Bloemendaal, Felicia M., Levin, Alon D., Wildenberg, Manon E., Koelink, Pim J., McRae, Bradford L., Salfeld, Jochen, Lum, Jenifer, van der Neut Kolfschoten, Marijn, Claassens, Jill W., Visser, Remco, Bentlage, Arthur, D’Haens, Geert R.A.M., Verbeek, J. Sjef, Vidarsson, Gestur, van den Brink, Gijs R.

“…Although tumor necrosis factor (TNF) antagonists reduce many clinical features of inflammatory bowel disease, complete mucosal healing occurs in fewer than 50%…”
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CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches by Argiriadi, Maria A, Benatuil, Lorenzo, Dubrovska, Ievgeniia, Egan, David A, Gao, Lei, Greischar, Amy, Hardman, Jennifer, Harlan, John, Iyer, Ramesh B, Judge, Russell A, Lake, Marc, Perron, Denise C, Sadhukhan, Ramkrishna, Sielaff, Bernhard, Sousa, Silvino, Wang, Rui, McRae, Bradford L

“…CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells…”
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Fc Receptor-mediated Effector Function Contributes to the Therapeutic Response of Anti-TNF Monoclonal Antibodies in a Mouse Model of Inflammatory Bowel Disease by McRae, Bradford L., Levin, Alon D., Wildenberg, Manon E., Koelink, Pim J., Bousquet, Peter, Mikaelian, Igor, Sterman, Annette Schwartz, Bryant, Shaughn, D’Haens, Geert, Kamath, Rajesh, Salfeld, Jochen, van den Brink, Gijs R

“…Background and Aims: Anti-tumour necrosis factor [TNF] monoclonal antibodies [infliximab, adalimumab] induce complete mucosal healing in a proportion of…”
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Anti-Inflammatory Effects of FTY720 Do Not Prevent Neuronal Cell Loss in a Rat Model of Optic Neuritis by Rau, Christian R, Hein, Katharina, Sättler, Muriel B, Kretzschmar, Benedikt, Hillgruber, Carina, McRae, Bradford L, Diem, Ricarda, Bähr, Mathias

“…In multiple sclerosis, long-term disability is caused by axonal and neuronal damage. Established therapies target primarily the inflammatory component of the…”
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Type I IFNs Inhibit Human Dendritic Cell IL-12 Production and Th1 Cell Development by McRae, Bradford L, Semnani, Roshanak Tolouei, Hayes, Mark P, van Seventer, Gijs A

“…We have investigated the role of type I IFNs (IFN-alpha and -beta) in human T cell differentiation using anti-CD3 mAb and allogeneic, in vitro-derived…”
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Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways by Chin, Chih-Liang, Pai, Madhavi, Bousquet, Peter F, Schwartz, Annette J, O'Connor, Elizabeth M, Nelson, Christine M, Hradil, Vincent P, Cox, Bryan F, McRae, Bradford L, Fox, Gerard B

“…Abstract USPIO-enhanced MRI allows non-invasive visualization of mononuclear cell infiltration into CNS lesions in MS and EAE. Herein, we show a distinct…”
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Sa1856 USTEKINUMAB MODULATES IL-12 AND IL-23-RELATED CELL TYPESPECIFIC INFLAMMATORY TRANSCRIPTIONAL STATES IN ULCERATIVE COLITIS INDUCTION THERAPY by Richards, Dylan, Venkat, Swati, Freeman, Tom C., Mcrae, Bradford, Hoops, Timothy, Marano, Colleen W., Branigan, Patrick

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Mechanisms and regulation of IL-22-mediated intestinal epithelial homeostasis and repair by Patnaude, Lori, Mayo, Martha, Mario, Regina, Wu, Xiaoming, Knight, Heather, Creamer, Kelly, Wilson, Sarah, Pivorunas, Valerie, Karman, Jozsef, Phillips, Lucy, Dunstan, Robert, Kamath, Rajesh V., McRae, Bradford, Terrillon, Sonia

“…Ulcerative colitis and Crohn's disease, collectively known as inflammatory bowel disease (IBD), are chronic inflammatory disorders of the intestine for which…”
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Suppression of CD4 + T cell activation by a novel inhibitor of Src family kinases by McRae, Bradford L., Wallace, Craig, Dixon, Kathleen Fitzgerald, Roux, Alyson, Mohan, Sukumari, Jia, Yong, Presky, David H., Tracey, Daniel E., Hirst, Gavin C.

“…The Src family kinases Lck and Fyn play an important role in T cell development and function. We have synthesized a novel small molecule, A-420983, which…”
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Su1729 DEVELOPMENT OF A CROHN'S DISEASE MOLECULAR ACTIVITY SCORE TO IDENTIFY REGION-SPECIFIC CHRONICALLY INFLAMED AND NON-INFLAMED PROCESSES by Richards, Dylan, Venkat, Swati, Terry, Natalie A., Vetter, Marion, Gomez, Mario, Freeman, Tom C., Mcrae, Bradford, Feagan, Brian G., Reinisch, Walter, Branigan, Patrick

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Su1728 GUSELKUMAB AND GOLIMUMAB COMBINATION INDUCTION THERAPY IN ULCERATIVE COLITIS RESULTS IN EARLY LOCAL TISSUE HEALING THAT IS SUSTAINED THROUGH GUSELKUMAB MAINTENANCE THERAPY by Richards, Dylan, Vetter, Marion, Germinaro, Matthew, Verstockt, Bram, Atreya, Raja, Panés, Julián, Sands, Bruce E., Feagan, Brian G., Mcrae, Bradford, Cua, Daniel, Branigan, Patrick, Freeman, Tom C.

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S1181 Guselkumab Decreases Key Cellular Inflammatory Processes Across Ileum and Colon Tissue in Crohn’s Disease by Richards, Dylan, Venkat, Swati, Ruane, Darren, Zeeman, Martha, Terry, Natalie A., Vetter, Marion, Gomez, Mario, Cua, Daniel, Freeman, Tom C., McRae, Bradford, Feagan, Brian G., Reinisch, Walter, Branigan, Patrick

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BCL2 Regulates Differentiation of Intestinal Fibroblasts by Weder, Bruce, Mamie, Céline, Rogler, Gerhard, Clarke, Stephen, McRae, Bradford, Ruiz, Pedro A, Hausmann, Martin

“…Abstract Background Fibrosis in patients with Crohn's disease (CD) results from an imbalance toward excessive fibrous tissue formation driven by fibroblasts…”
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Su1732 GUSELKUMAB INDUCTION RESTORES INTESTINAL IMMUNE HOMEOSTASIS AND PROMOTES EPITHELIAL REPAIR IN MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS by Sridhar, Sunan, Hart, Amy, Venkat, Swati, Ruane, Darren, Horowitz, Dan, Lee, Tae, Waterworth, Dawn M., Huang, Kuan-Hsiang G., Germinaro, Matthew, Vetter, Marion, Cua, Daniel, Freeman, Tom C., Sisk, Christopher, Mcrae, Bradford, Verstockt, Bram, Rubin, David T., Sands, Bruce E., Branigan, Patrick

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631 - BCL2 Regulates Differentiation of Intestinal Fibroblasts by Weder, Bruce, Mamie, Céline, Rogler, Gerhard, Clarke, Stephen, McRae, Bradford L., Ruiz-Castro, Pedro A., Hausmann, Martin

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