Search Results - "McQualter, Jonathan"

Endogenous lung stem cells for lung regeneration by McQualter, Jonathan L

“…Lifelong maintenance of a healthy lung requires resident stem cells to proliferate according to tissue requirements. Once thought to be a quiescent tissue,…”
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Evidence of an Epithelial Stem/Progenitor Cell Hierarchy in the Adult Mouse Lung by McQualter, Jonathan L., Yuen, Karen, Williams, Brenda, Bertoncello, Ivan

“…The role of lung epithelial stem cells in maintenance and repair of the adult lung is ill-defined, and their identity remains contentious because of the lack…”
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Single-Cell Reconstruction of Human Basal Cell Diversity in Normal and Idiopathic Pulmonary Fibrosis Lungs by Carraro, Gianni, Mulay, Apoorva, Yao, Changfu, Mizuno, Takako, Konda, Bindu, Petrov, Martin, Lafkas, Daniel, Arron, Joe R, Hogaboam, Cory M, Chen, Peter, Jiang, Dianhua, Noble, Paul W, Randell, Scott H, McQualter, Jonathan L, Stripp, Barry R

“…Declining lung function in patients with interstitial lung disease is accompanied by epithelial remodeling and progressive scarring of the gas-exchange region…”
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Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection by Ray, Samriddha, Chiba, Norika, Yao, Changfu, Guan, Xiangrong, McConnell, Alicia M., Brockway, Brian, Que, Loretta, McQualter, Jonathan L., Stripp, Barry R.

“…Recent studies have implicated keratin 5 (KRT5)+ cells in repopulation of damaged lung tissue following severe H1N1 influenza virus infection. However, the…”
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COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link by Bozinovski, Steven, Vlahos, Ross, Anthony, Desiree, McQualter, Jonathan, Anderson, Gary, Irving, Louis, Steinfort, Daniel

“…Cigarette smoking has reached epidemic proportions within many regions of the world and remains the highest risk factor for chronic obstructive pulmonary…”
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Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease by Bozinovski, Steven, Uddin, Mohib, Vlahos, Ross, Thompson, Michelle, McQualter, Jonathan L, Merritt, Anne-Sophie, Wark, Peter A B, Hutchinson, Anastasia, Irving, Louis B, Levy, Bruce D, Anderson, Gary P

“…Chronic obstructive pulmonary disease (COPD) will soon be the third most common cause of death globally. Despite smoking cessation, neutrophilic mucosal…”
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Concise Review: Deconstructing the Lung to Reveal Its Regenerative Potential by McQualter, Jonathan L., Bertoncello, Ivan

“…Despite burgeoning interest in the potential of cellular therapies in lung regenerative medicine, progress in delivering these therapies has been confounded by…”
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Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer by Tsantikos, Evelyn, Gottschalk, Timothy A, L'Estrange-Stranieri, Elan, O'Brien, Caitlin A, Raftery, April L, Wickramasinghe, Lakshanie C, McQualter, Jonathan L, Anderson, Gary P, Hibbs, Margaret L

“…The epidemiological patterns of incident chronic obstructive pulmonary disease (COPD) and lung adenocarcinoma are changing, with an increasing fraction of…”
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Sin3a regulates epithelial progenitor cell fate during lung development by Yao, Changfu, Carraro, Gianni, Konda, Bindu, Guan, Xiangrong, Mizuno, Takako, Chiba, Norika, Kostelny, Matthew, Kurkciyan, Adrianne, David, Gregory, McQualter, Jonathan L, Stripp, Barry R

“…Mechanisms that regulate tissue-specific progenitors for maintenance and differentiation during development are poorly understood. Here, we demonstrate that…”
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LysoTracker is a marker of differentiated alveolar type II cells by Van der Velden, Joanne L, Bertoncello, Ivan, McQualter, Jonathan L

“…LysoTracker Green DND-26 is a fluorescent dye that stains acidic compartments in live cells and has been shown to selectively accumulate in lamellar bodies in…”
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Endogenous Fibroblastic Progenitor Cells in the Adult Mouse Lung Are Highly Enriched in the Sca‐1 Positive Cell Fraction by McQualter, Jonathan L., Brouard, Nathalie, Williams, Brenda, Baird, Brandi N., Sims‐Lucas, Sunder, Yuen, Karen, Nilsson, Susan K., Simmons, Paul J., Bertoncello, Ivan

“…Originally identified as a marker specifying murine hematopoietic stem cells, the Sca‐1 antigen has since been shown to be differentially expressed by…”
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Clonal culture of adult mouse lung epithelial stem/progenitor cells by McQualter, Jonathan L, Bertoncello, Ivan

“…Clonal culture of stem cells is crucial for their identification, and the characterization of the cellular and molecular mechanisms that regulate their…”
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Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice by Bozinovski, Steven, Seow, Huei Jiunn, Chan, Sheau Pyng Jamie, Anthony, Desiree, McQualter, Jonathan, Hansen, Michelle, Jenkins, Brendan J, Anderson, Gary P, Vlahos, Ross

“…Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). Interleukin-17A (IL-17A) is a pivotal cytokine that regulates lung…”
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Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice by Fung, Nok Him, Nguyen, Quynh Anh, Owczarek, Catherine, Wilson, Nick, Doomun, Nadeem Elahee, De Souza, David, Quinn, Kylie, Selemidis, Stavros, McQualter, Jonathan, Vlahos, Ross, Wang, Hao, Bozinovski, Steven

“…Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent…”
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Lung stem cells: Do they exist? by Bertoncello, Ivan, McQualter, Jonathan L.

“…Recognition of the potential of stem cell‐based therapies for alleviating intractable lung diseases has provided the impetus for research aimed at identifying…”
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Functional analysis of two distinct bronchiolar progenitors during lung injury and repair by Teisanu, Roxana M, Chen, Huaiyong, Matsumoto, Keitaro, McQualter, Jonathan L, Potts, Erin, Foster, W Michael, Bertoncello, Ivan, Stripp, Barry R

“…Air spaces of the mammalian lung are lined by a specialized epithelium that is maintained by endogenous progenitor cells. Within bronchioles, the abundance and…”
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Delineating the hierarchy of lung progenitor cells and their response to influenza by McQualter, Jonathan L, Laurent, Geoffrey J

“…Influenza viruses are significant human respiratory pathogens that cause acute inflammation and widespread epithelial cell death in the lungs [1]. Yet,…”
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House Dust Mite Aeroallergen Suppresses Leukocyte Phagocytosis and Netosis Initiated by Pneumococcal Lung Infection by Papanicolaou, Angelica, Wang, Hao, McQualter, Jonathan, Aloe, Christian, Selemidis, Stavros, Satzke, Catherine, Vlahos, Ross, Bozinovski, Steven

“…Asthmatics are highly susceptible to developing lower respiratory tract infections caused by (SPN, the pneumococcus). It has recently emerged that underlying…”
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Harnessing the potential of lung stem cells for regenerative medicine by McQualter, Jonathan L., Anthony, Desiree, Bozinovski, Steven, Prêle, Cecilia M., Laurent, Geoffrey J.

“…In response to recurrent exposure to environmental insults such as allergens, pollution, irritants, smoke and viral/bacterial infection, the epithelium of the…”
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SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF‐1R‐dependent signaling by Anthony, Desiree, McQualter, Jonathan L., Bishara, Maria, Lim, Ee X., Yatmaz, Selcuk, Seow, Huei Jiunn, Hansen, Michelle, Thompson, Michelle, Hamilton, John A., Irving, Louis B., Levy, Bruce D., Vlahos, Ross, Anderson, Gary P., Bozinovski, Steven

“…Serum amyloid A (SAA) is expressed locally in chronic inflammatory conditions such as chronic obstructive pulmonary disease (COPD), where macrophages that do…”
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