Search Results - "McQuaid, Loretta"

Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase by Jones, Charles D, Audia, James E, Lawhorn, David E, McQuaid, Loretta A, Neubauer, Blake L, Pike, Andrew J, Pennington, Pamela A, Stamm, Nancy B, Toomey, Richard E, Hirsch, Kenneth S

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3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex by McQuaid, Loretta A, Smith, Edward C. R, Lodge, David, Pralong, Etienne, Wikel, James H, Calligaro, David O, O'Malley, Patrick J

“…The N-methyl-D-aspartic acid (NMDA) ion channel complex has been implicated in a number of excitotoxic events leading to neuronal degeneration. The…”
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Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones by McQuaid, Loretta A, Smith, Edward C. R, South, Kimberly K, Mitch, Charles H, Schoepp, Darryle D, True, Rebecca A, Calligaro, David O, O'Malley, Patrick J, Lodge, David, Ornstein, Paul L

“…As part of our program aimed at the development of potent excitatory amino acid antagonists, we synthesized and evaluated a series of substituted…”
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Total synthesis of (.+-.)-methyl shikimate and (.+-.)-3-phosphoshikimic acid by Bartlett, Paul A, McQuaid, Loretta A

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An enantioselective synthesis of D-(-)- and L-(+)-2-amino-3-phosphonopropanoic acid by Smith, Edward C. R, McQuaid, Loretta A, Paschal, Jonathan W, DeHoniesto, Juel

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Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity by McQuaid, Loretta A, Latz, Jane E, Clemens, James A, Fuller, Ray W, Wong, David T, Mason, Norman R

“…Two series of tetrahydroindazoles were synthesized and evaluated for dopaminergic activity. A number of these partial ergoline analogues possess substituents…”
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5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors by McNamara, D, Smith, E C, Calligaro, D O, O'Malley, P J, McQuaid, L A, Dingledine, R

“…Fourteen substituted derivatives of kynurenic acid were compared for their ability to block ionic currents evoked by N-methyl-D-aspartate (NMDA) plus glycine,…”
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Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid by Schoepp, D D, Johnson, B G, Smith, E C, McQuaid, L A

“…DL-2-Amino-3-phosphonopropionic acid, a phosphonate-substituted derivative of aspartic acid, has been shown to be an inhibitor of excitatory amino…”
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LY191704: A Selective, Nonsteroidal Inhibitor of Human Steroid 5α- Reductase Type 1 by Hirsch, Kenneth S., Jones, Charles D., Audia, James E., Andersson, Stefan, McQuaid, Loretta, Stamm, Nancy B., Neubauer, Blake L., Pennington, Pam, Toomey, Richard E., Russell, David W.

“…Androgens, in particular dihydrotestosterone (DHT), play a key role in differentiation, growth, and maintenance of the mammalian prostate. Production of DHT…”
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Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions by Smith, Edward C.R., McQuaid, Loretta A., Goode, Robin L., McNulty, Ann M., Neubauer, Blake Lee, Rocco, Vincent P., Audia, James E.

“…Benzoquinolinones have been shown to be potent, selective inhibitors of the Type I 5α-reductase enzyme, which is responsible for the production of…”
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LY191704 inhibits type I steroid 5α-reductase in human scalp by NEUBAUER, B. L, GRAY, H. M, TINDALL, D. J, TOOMEY, R. E, YAO, R. C, AUDIA, J. E, HANKE, C. W, HIRSCH, K. S, HSIAO, K. C, JONES, C. D, KUMAR, M. V, LAWHORN, D. E, LINDZEY, J, MCQUAID, L

“…Conversion of testosterone to dihydrotestosterone (DHT) has been demonstrated to be catalyzed by two isoforms of steroid 5 alpha-reductase, designated types I…”
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Creation of a knowledge-based system to accelerate drug development by HYNES, M. D, GETZIN, S. A, MCQUAID, L, SEWARD, C. M, MILLER, N. L, FIELD-PEREZ, R. R

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