Search Results - "McQUIBBAN, ANGUS"

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway by Moskal, Natalia, Riccio, Victoria, Bashkurov, Mikhail, Taddese, Rediet, Datti, Alessandro, Lewis, Peter N., Angus McQuibban, G.

“…The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria…”
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An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets by Moskal, Natalia, Visanji, Naomi P, Gorbenko, Olena, Narasimhan, Vijay, Tyrrell, Hannah, Nash, Jess, Lewis, Peter N, McQuibban, G Angus

“…Failures in mitophagy, a process by which damaged mitochondria are cleared, results in neurodegeneration, while enhancing mitophagy promotes the survival of…”
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Caenorhabditis elegans is a useful model for anthelmintic discovery by Burns, Andrew R., Luciani, Genna M., Musso, Gabriel, Bagg, Rachel, Yeo, May, Zhang, Yuqian, Rajendran, Luckshika, Glavin, John, Hunter, Robert, Redman, Elizabeth, Stasiuk, Susan, Schertzberg, Michael, Angus McQuibban, G., Caffrey, Conor R., Cutler, Sean R., Tyers, Mike, Giaever, Guri, Nislow, Corey, Fraser, Andy G., MacRae, Calum A., Gilleard, John, Roy, Peter J.

“…Parasitic nematodes infect one quarter of the world’s population and impact all humans through widespread infection of crops and livestock. Resistance to…”
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Deubiquitinating enzymes regulate PARK2-mediated mitophagy by Wang, Yuqing, Serricchio, Mauro, Jauregui, Miluska, Shanbhag, Riya, Stoltz, Tasha, Di Paolo, Caitlin T, Kim, Peter K, McQuibban, G Angus

“…The selective degradation of mitochondria by the process of autophagy, termed mitophagy, is one of the major mechanisms of mitochondrial quality control. The…”
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The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism by Shi, Guang, McQuibban, G. Angus

“…Mitochondrial quality control (MQC) systems are essential for mitochondrial health and normal cellular function. Dysfunction of MQC is emerging as a central…”
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ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy by Wang, Yuqing, Nartiss, Yulia, Steipe, Boris, McQuibban, G. Angus, Kim, Peter K.

“…Reactive oxygen species (ROS) have been implicated as a signal for general autophagy. Both mitochondrial-produced and exogenous ROS induce autophagosome…”
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Meiotic viral attenuation through an ancestral apoptotic pathway by Gao, Jie, Chau, Sabrina, Chowdhury, Fuad, Zhou, Tina, Hossain, Saif, McQuibban, G. Angus, Meneghini, Marc D.

“…The programmed release of apoptogenic proteins from mitochondria is a core event of apoptosis, although ancestral roles of this phenomenon are not known. In…”
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Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy by Riccio, Victoria, Demers, Nicholas, Hua, Rong, Vissa, Miluska, Cheng, Derrick T, Strilchuk, Amy Wong, Wang, Yuqing, McQuibban, G Angus, Kim, Peter Kijun

“…The regulation of organelle abundance is critical for cell function and survival; however, the mechanisms responsible are not fully understood. In this study,…”
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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery by Yang, Yufeng, Ouyang, Yingshi, Yang, Lichuan, Beal, M. Flint, McQuibban, Angus, Vogel, Hannes, Lu, Bingwei

“…Mitochondria form dynamic tubular networks that undergo frequent morphological changes through fission and fusion, the imbalance of which can affect cell…”
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PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics by Nag, Sudeshna, Szederkenyi, Kaitlin, Gorbenko, Olena, Tyrrell, Hannah, Yip, Christopher M., McQuibban, G. Angus

“…Mitochondrial morphology is regulated by the post-translational modifications of the dynamin family GTPase proteins including mitofusin 1 (MFN1), MFN2, and…”
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The atypical cadherin fat directly regulates mitochondrial function and metabolic state by Sing, Anson, Tsatskis, Yonit, Fabian, Lacramioara, Hester, Ian, Rosenfeld, Robyn, Serricchio, Mauro, Yau, Norman, Bietenhader, Maïlis, Shanbhag, Riya, Jurisicova, Andrea, Brill, Julie A, McQuibban, G Angus, McNeill, Helen

“…Fat (Ft) cadherins are enormous cell adhesion molecules that function at the cell surface to regulate the tumor-suppressive Hippo signaling pathway and planar…”
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Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease by GUANG SHI, LEE, Jeffrey R, GRIMES, David A, RACACHO, Lemuel, YE, David, YANG, Howard, ROSS, Owen A, FARRER, Matthew, MCQUIBBAN, G. Angus, BULMAN, Dennis E

“…Molecular genetics has linked mitochondrial dysfunction to the pathogenesis of Parkinson's disease by the discovery of rare, inherited mutations in gene…”
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Mitochondrial membrane remodelling regulated by a conserved rhomboid protease by Freeman, Matthew, McQuibban, G. Angus, Saurya, Saroj

“…Rhomboid proteins are intramembrane serine proteases that activate epidermal growth factor receptor (EGFR) signalling in Drosophila. Rhomboids are conserved…”
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Protocol for evaluating mitochondrial morphology changes in response to CCCP-induced stress through open-source image processing software by Nag, Sudeshna, Szederkenyi, Kaitlin, Yip, Christopher M., McQuibban, G. Angus

“…Mitochondrial morphology is an indicator of cellular health and function; however, its quantification and categorization into different subclasses is a…”
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A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome by McQuibban, Angus G., Joza, Nicholas, Megighian, Aram, Scorzeto, Michele, Zanini, Damiano, Reipert, Siegfried, Richter, Constance, Schweyen, Rudolf J., Nowikovsky, Karin

“…Human Wolf-Hirschhorn syndrome (WHS) is a multigenic disorder resulting from a hemizygous deletion on chromosome 4. LETM1 is the best candidate gene for…”
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Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo by McQuibban, G. Angus, Gong, Jiang-Hong, Wong, Julie P., Wallace, John L., Clark-Lewis, Ian, Overall, Christopher M.

“…Monocyte chemoattractant protein (MCP)–3 is inactivated upon cleavage by the matrix metalloproteinase (MMP) gelatinase A (MMP-2). We investigated the…”
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Inflammation Dampened by Gelatinase a Cleavage of Monocyte Chemoattractant Protein-3 by McQuibban, G. Angus, Gong, Jiang-Hong, Tam, Eric M., Christopher A. G. Mc Culloch, Clark-Lewis, Ian, Overall, Christopher M.

“…Tissue degradation by the matrix metalloproteinase gelatinase A is pivotal to inflammation and metastases. Recognizing the catalytic importance of…”
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Phospholipid Association Is Essential for Dynamin-related Protein Mgm1 to Function in Mitochondrial Membrane Fusion by Rujiviphat, Jarungjit, Meglei, Gabriela, Rubinstein, John L., McQuibban, G.Angus

“…Mgm1, the yeast ortholog of mammalian OPA1, is a key component in mitochondrial membrane fusion and is required for maintaining mitochondrial dynamics and…”
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Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery by Burns, Andrew R., Luciani, Genna M., Musso, Gabriel, Bagg, Rachel, Yeo, May, Zhang, Yuqian, Rajendran, Luckshi, Glavin, John, Hunter, Robert, Redman, Elizabeth, Stasiuk, Susan, Schertzberg, Michael, McQuibban, G. Angus, Caffrey, Conor R., Cutler, Sean R., Tyers, Mike, Giaever, Guri, Nislow, Corey, Fraser, Andy G., MacRae, Calum A., Gilleard, John, Roy, Peter J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin by Whitworth, Alexander J, Lee, Jeffrey R, Ho, Venus M-W, Flick, Robert, Chowdhury, Ruhena, McQuibban, G Angus

“…Parkinson's disease (PD) is a common neurodegenerative disorder caused by loss of midbrain dopaminergic neurons, the pathogenetic mechanisms of which remain…”
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