Search Results - "McPhie, D. L."

Genetic and clinical factors predict lithium’s effects on PER2 gene expression rhythms in cells from bipolar disorder patients by McCarthy, M J, Wei, H, Marnoy, Z, Darvish, R M, McPhie, D L, Cohen, B M, Welsh, D K

“…Bipolar disorder (BD) is associated with abnormal circadian rhythms. In treatment responsive BD patients, lithium (Li) stabilizes mood and reduces suicide…”
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Internal Ca2+Mobilization is Altered in Fibroblasts from Patients with Alzheimer Disease by Ito, Etsuro, Oka, Kotaro, Etcheberrigaray, Rene, Nelson, Thomas J., McPhie, Donna L., Tofel-Grehl, Beth, Gibson, Gary E., Alkon, Daniel L.

“…The recent demonstration of K+channel dysfunction in fibroblasts from Alzheimer disease (AD) patients and past observations of Ca2+-mediated K+channel…”
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Imaging of Memory-Specific Changes in the Distribution of Protein Kinase C in the Hippocampus by Olds, James L., Anderson, Matthew L., McPhie, Donna L., Staten, Latonia D., Alkon, Daniel L.

“…Activation of protein kinase C (PKC) can mimic the biophysical effects of associative learning on neurons. Furthermore, classical conditioning of the rabbit…”
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Cell specificity of molecular changes during memory storage by McPhie, D L, Matzel, L D, Olds, J L, Lester, D S, Kuzirian, A M, Alkon, D L

“…The aeolid nudibranch, Hermissenda crassicornis, exhibits Pavlovian conditioning to paired light and rotational stimuli and it has been suggested that protein…”
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Alzheimer’s disease: a dysfunction of the amyloid precursor protein by Neve, Rachael L., McPhie, Donna L., Chen, Yuzhi

“…In this review, we argue that at least one insult that causes Alzheimer’s disease (AD) is disruption of the normal function of the amyloid precursor protein…”
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Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein by Berger-Sweeney, Joanne, McPhie, Donna L, Arters, Jill A, Greenan, Jane, Oster-Granite, Mary Lou, Neve, Rachael L

“…In Alzheimer's disease (AD), a progressive decline of cognitive functions is accompanied by neuropathology that includes the degeneration of neurons and the…”
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DNA Synthesis and Neuronal Apoptosis Caused by Familial Alzheimer Disease Mutants of the Amyloid Precursor Protein Are Mediated by the p21 Activated Kinase PAK3 by McPhie, Donna L, Coopersmith, Robert, Hines-Peralta, Andrew, Chen, Yuzhi, Ivins, Kathryn J, Manly, Susan P, Kozlowski, Michael R, Neve, Kim A, Neve, Rachael L

“…Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals with Alzheimer disease (AD). However, the signaling mechanisms that…”
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APP-BP1 Mediates APP-Induced Apoptosis and DNA Synthesis and Is Increased in Alzheimer's Disease Brain by Chen, Yuzhi, Liu, Wenyun, McPhie, Donna L., Hassinger, Linda, Neve, Rachael L.

“…APP-BP1, first identified as an amyloid precursor protein (APP) binding protein, is the regulatory subunit of the activating enzyme for the small…”
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A beta 42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3 beta signaling-dependent mechanism by Suhara, T, Magrane, J, Rosen, K, Christensen, R, Kim, H-S, Zheng, B, McPhie, D L, Walsh, K, Querfurth, H

“…The application of beta -amyloid (A beta ) is cytotoxic to endothelial cells, promotes vasoconstriction and impairs nitric oxide (NO) generation or action…”
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The Amyloid Precursor Protein-binding Protein APP-BP1 Drives the Cell Cycle through the S-M Checkpoint and Causes Apoptosis in Neurons by Chen, Yuzhi, McPhie, Donna L., Hirschberg, Joseph, Neve, Rachael L.

“…APP-BP1 binds to the amyloid precursor protein (APP) carboxyl-terminal domain. Recent work suggests that APP-BP1 participates in a novel…”
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Contraction of Neuronal Branching Volume: An Anatomic Correlate of Pavlovian Conditioning by Alkon, D. L., Ikeno, H., Dworkin, J., McPhie, D. L., Olds, J. L., Lederhendler, I., Matzel, L., Schreurs, B. G., Kuzirian, A., Collin, C., Yamoah, E.

“…Associative memory of the mollusc Hermissenda crassicornis, previously correlated with changes of specific K+currents, protein phosphorylation, and increased…”
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Age-Dependent Neuronal and Synaptic Degeneration in Mice Transgenic for the C Terminus of the Amyloid Precursor Protein by Oster-Granite, Mary Lou, McPhie, Donna L, Greenan, Jane, Neve, Rachael L

“…The molecular basis for the degeneration of neurons and the deposition of amyloid in plaques and in the cerebrovasculature in Alzheimer's disease (AD) is…”
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Overexpression in Neurons of Human Presenilin-1 or a Presenilin-1 Familial Alzheimer Disease Mutant Does Not Enhance Apoptosis by Bursztajn, Sherry, DeSouza, Richard, McPhie, Donna L, Berman, S. A, Shioi, Junichi, Robakis, Nikolaos K, Neve, Rachael L

“…Programmed cell death, or apoptosis, has been implicated in Alzheimer's disease (AD). DNA damage was assessed in primary cortical neurons infected with herpes…”
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Lateralization of membrane-associated protein kinase C in rat piriform cortex: specific to operant training cues in the olfactory modality by Olds, J L, Bhalla, U S, McPhie, D L, Lester, D S, Bower, J M, Alkon, D L

“…Rats were trained on an olfactory and a control modality (auditory or visual) discrimination task and brain membrane-associated protein kinase C (mPKC) was…”
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The Neuronal Growth-Associated Protein GAP-43 Interacts with Rabaptin-5 and Participates in Endocytosis by Neve, Rachael L, Coopersmith, Robert, McPhie, Donna L, Santeufemio, Christopher, Pratt, Kara G, Murphy, Curran J, Lynn, Stephanie D

“…Structural plasticity of nerve cells is a requirement for activity-dependent changes in the brain. The growth-associated protein GAP-43 is thought to be one…”
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Enhanced BK-induced calcium responsiveness in PC12 cells expressing the C100 fragment of the amyloid precursor protein by Pascale, Alessia, Bhagavan, Seetha, Nelson, Thomas J, Neve, Rachael L, McPhie, Donna L, Etcheberrigaray, René

“…Several lines of evidence have implicated the amyloid precursor protein (APP) and its metabolic products as key players in Alzheimer's disease (AD)…”
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Repeated Exposure to Rewarding Brain Stimulation Downregulates GluR1 Expression in the Ventral Tegmental Area by Carlezon, William A, Todtenkopf, Mark S, McPhie, Donna L, Pimentel, Patricia, Pliakas, Andrea M, Stellar, James R, Trzcinska, Monika

“…There is considerable evidence that drug reward and brain stimulation reward (BSR) share common neural substrates. Although it is known that exposure to drugs…”
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β-Amyloid Peptide Expression Is Sufficient for Myotube Death: Implications for Human Inclusion Body Myopathy by Querfurth, Henry W., Suhara, Toshimitsu, Rosen, Kenneth M., McPhie, Donna L., Fujio, Yasushi, Tejada, George, Neve, Rachael L., Adelman, Lester S., Walsh, Kenneth

“…Inclusion body myositis (sIBM) is the most common disorder of skeletal muscle in aged humans. It shares biochemical features with Alzheimer's disease,…”
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Neuronal Expression of β-Amyloid Precursor Protein Alzheimer Mutations Causes Intracellular Accumulation of a C-terminal Fragment Containing Both the Amyloid β and Cytoplasmic Domains by McPhie, Donna L., Lee, Robert K.K., Eckman, Christopher B., Olstein, Daniel H., Durham, Stephanie P., Yager, Debra, Younkin, Steven G., Wurtman, Richard J., Neve, Rachael L.

“…Five different Alzheimer mutations of the β-amyloid precursor protein (APP) were expressed in neurons via recombinant herpes simplex virus (HSV) vectors, and…”
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β-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer’s disease mutations by McPhie, Donna L, Golde, Todd, Eckman, Christopher B, Yager, Debra, Brant, Justin B, Neve, Rachael L

“…The amyloid precursor protein (APP) is cleaved by two enzymes, β-secretase and γ-secretase, to generate the pathological amyloid β (Aβ) peptide. Expression of…”
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