Search Results - "McPherson, Ruth"

Genetics of Coronary Artery Disease by McPherson, Ruth, Tybjaerg-Hansen, Anne

“…Genetic factors contribute importantly to the risk of coronary artery disease (CAD), and in the past decade, there has been major progress in this area. The…”
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Chromosome 9p21 and Coronary Artery Disease by McPherson, Ruth

“…Genomewide association studies have implicated a region on chromosome 9p21 in coronary artery disease. This association is probably driven by two genes that…”
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2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult by Anderson, Todd J., MD, Grégoire, Jean, MD, Pearson, Glen J., PharmD, Barry, Arden R., PharmD, Couture, Patrick, MD, Dawes, Martin, MD, Francis, Gordon A., MD, Genest, Jacques, MD, Grover, Steven, MD, Gupta, Milan, MD, Hegele, Robert A., MD, Lau, David C., MD, PhD, Leiter, Lawrence A., MD, Lonn, Eva, MD, Mancini, G.B. John, MD, McPherson, Ruth, MD, PhD, Ngui, Daniel, MD, Poirier, Paul, MD, PhD, Sievenpiper, John L., MD, PhD, Stone, James A., MD, PhD, Thanassoulis, George, MD, Ward, Richard, MD

“…Abstract Since the publication of the 2012 guidelines new literature has emerged to inform decision-making. The 2016 guidelines primary panel selected a number…”
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2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults by Pearson, Glen J., Thanassoulis, George, Anderson, Todd J., Barry, Arden R., Couture, Patrick, Dayan, Natalie, Francis, Gordon A., Genest, Jacques, Grégoire, Jean, Grover, Steven A., Gupta, Milan, Hegele, Robert A., Lau, David, Leiter, Lawrence A., Leung, Alexander A., Lonn, Eva, Mancini, G.B. John, Manjoo, Priya, McPherson, Ruth, Ngui, Daniel, Piché, Marie-Eve, Poirier, Paul, Sievenpiper, John, Stone, James, Ward, Rick, Wray, Wendy

“…The 2021 guidelines primary panel selected clinically relevant questions and produced updated recommendations, on the basis of important new findings that have…”
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Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition by Soubeyrand, Sébastien, Lau, Paulina, McPherson, Ruth

“…Tribbles related homolog 1 (TRIB1) contributes to lipid and glucose homeostasis by facilitating the degradation of cognate cargos by the proteasome. In view of…”
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2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult by Anderson, Todd J., MD, Grégoire, Jean, MD, Hegele, Robert A., MD, Couture, Patrick, MD, PhD, Mancini, G.B. John, MD, McPherson, Ruth, MD, PhD, Francis, Gordon A., MD, Poirier, Paul, MD, PhD, Lau, David C., MD, PhD, Grover, Steven, MD, Genest, Jacques, MD, Carpentier, André C., MD, Dufour, Robert, MD, Gupta, Milan, MD, Ward, Richard, MD, Leiter, Lawrence A., MD, Lonn, Eva, MD, Ng, Dominic S., MD, PhD, Pearson, Glen J., PharmD, Yates, Gillian M., MN, NP, Stone, James A., MD, PhD, Ur, Ehud, MB

“…Abstract Many developments have occurred since the publication of the widely-used 2009 Canadian Cardiovascular Society (CCS) Dyslipidemia guidelines. Here, we…”
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Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia by Khera, Amit V., MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Lawson, Kim S., MS, Bartz, Traci M., MS, Deng, Xuan, MSc, van Leeuwen, Elisabeth M, Natarajan, Pradeep, MD, MMSc, Emdin, Connor A., HBSc, Bick, Alexander G., PhD, Morrison, Alanna C., PhD, Brody, Jennifer A., BA, Gupta, Namrata, PhD, Nomura, Akihiro, MD, Kessler, Thorsten, MD, Duga, Stefano, PhD, Bis, Joshua C., PhD, van Duijn, Cornelia M., PhD, Cupples, L. Adrienne, PhD, Psaty, Bruce, MD, PhD, Rader, Daniel J., MD, Danesh, John, DPhil, Schunkert, Heribert, MD, McPherson, Ruth, MD, Farrall, Martin, MD, Watkins, Hugh, MD, PhD, Lander, Eric, PhD, Wilson, James G., MD, Correa, Adolfo, MD, PhD, Boerwinkle, Eric, PhD, Merlini, Piera Angelica, MD, Ardissino, Diego, MD, Saleheen, Danish, MBBS, PhD, Gabriel, Stacey, PhD, Kathiresan, Sekar, MD

“…Abstract Background Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl),…”
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Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of cardiometabolic phenotypes by Nikpay, Majid, Beehler, Kaitlyn, Valsesia, Armand, Hager, Jorg, Harper, Mary-Ellen, Dent, Robert, McPherson, Ruth

“…To identify genetic variants that have a regulatory impact on circulating microRNAs (miRNAs) and to connect genetic risk to blood traits/biomarkers through the…”
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Chromosome 9p21.3 Locus for Coronary Artery Disease by McPherson, Ruth, MD, PhD

“…An early poster child for the success of genome-wide association studies, the chromosome 9p21.3 locus is robustly linked to early atherosclerosis, abdominal…”
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A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease by Emdin, Connor A, Haas, Mary E, Khera, Amit V, Aragam, Krishna, Chaffin, Mark, Klarin, Derek, Hindy, George, Jiang, Lan, Wei, Wei-Qi, Feng, Qiping, Karjalainen, Juha, Havulinna, Aki, Kiiskinen, Tuomo, Bick, Alexander, Ardissino, Diego, Wilson, James G, Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J, Samani, Nilesh J, Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Chang, Kyong-Mi, Vujkovic, Marijana, Voight, Ben, Damrauer, Scott, Lynch, Julie, Kaplan, David, Serper, Marina, Tsao, Philip, Mercader, Josep, Hanis, Craig, Daly, Mark, Denny, Joshua, Gabriel, Stacey, Kathiresan, Sekar

“…Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime…”
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Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity by Ramkhelawon, Bhama, Hennessy, Elizabeth J, Ménager, Mickaël, Ray, Tathagat Dutta, Sheedy, Frederick J, Hutchison, Susan, Wanschel, Amarylis, Oldebeken, Scott, Geoffrion, Michele, Spiro, Westley, Miller, George, McPherson, Ruth, Rayner, Katey J, Moore, Kathryn J

“…Obesity is marked by a state of low-grade inflammation, including the accumulation of macrophages in the adipose tissue, which results in insulin resistance…”
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Epigenome-Wide Study Identified Methylation Sites Associated with the Risk of Obesity by Nikpay, Majid, Ravati, Sepehr, Dent, Robert, McPherson, Ruth

“…Here, we performed a genome-wide search for methylation sites that contribute to the risk of obesity. We integrated methylation quantitative trait locus (mQTL)…”
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Off-target effects of CRISPRa on interleukin-6 expression by Soubeyrand, Sébastien, Lau, Paulina, Peters, Victoria, McPherson, Ruth

“…Inactive fusion variants of the CRISPR-Cas9 system are increasingly being used as standard methodology to study transcription regulation. Their ability to…”
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TRIB1 is a positive regulator of hepatocyte nuclear factor 4-alpha by Soubeyrand, Sébastien, Martinuk, Amy, McPherson, Ruth

“…The TRIB1 locus has been linked to both cardiovascular disease and hepatic steatosis. Recent efforts have revealed TRIB1 to be a major regulator of liver…”
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Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels by Emdin, Connor A., DPhil, Khera, Amit V., MD, Natarajan, Pradeep, MD, Klarin, Derek, MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Stitziel, Nathan O., MD, PhD, Nomura, Akihiro, MD, Zekavat, Seyedeh M., BSc, Bick, Alexander G., MD, Gupta, Namrata, PhD, Asselta, Rosanna, PhD, Duga, Stefano, PhD, Merlini, Piera Angelica, MD, Correa, Adolfo, MD, Kessler, Thorsten, MD, Wilson, James G., MD, Bown, Matthew J., MD, Hall, Alistair S., MD, Braund, Peter S., PhD, Samani, Nilesh J., MD, Schunkert, Heribert, MD, Marrugat, Jaume, MD, PhD, Elosua, Roberto, MD, PhD, McPherson, Ruth, MD, Farrall, Martin, PhD, Watkins, Hugh, MD, PhD, Willer, Cristen, PhD, Abecasis, Gonçalo R., PhD, Felix, Janine F., MD, PhD, Vasan, Ramachandran S., MD, Lander, Eric, PhD, Rader, Daniel J., MD, Danesh, John, MSc, DPhil, Ardissino, Diego, MD, Gabriel, Stacey, PhD, Saleheen, Danish, MD, Kathiresan, Sekar, MD

“…Abstract Background Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk…”
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Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells by Aguer, Céline, Gambarotta, Daniela, Mailloux, Ryan J, Moffat, Cynthia, Dent, Robert, McPherson, Ruth, Harper, Mary-Ellen

“…Human primary myotubes are highly glycolytic when cultured in high glucose medium rendering it difficult to study mitochondrial dysfunction. Galactose is known…”
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Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals by Antoun, Ghadi, McMurray, Fiona, Thrush, A. Brianne, Patten, David A., Peixoto, Alyssa C., Slack, Ruth S., McPherson, Ruth, Dent, Robert, Harper, Mary-Ellen

“…Aims/hypothesis Skeletal muscle mitochondrial dysfunction has been documented in patients with type 2 diabetes mellitus; however, specific respiratory defects…”
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Convergence of biomarkers and risk factor trait loci of coronary artery disease at 3p21.31 and HLA region by Nikpay, Majid, McPherson, Ruth

“…Here we seek to identify molecular biomarkers that mediate the effect of risk factors on coronary artery disease (CAD). We perform a SNP-based multiomics data…”
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miR1908-5p regulates energy homeostasis in hepatocyte models by Soubeyrand, Sébastien, Lau, Paulina, Beehler, Kaitlyn, McShane, Kelsey, McPherson, Ruth

“…We previously identified genomic variants that are quantitative trait loci for circulating miR-1908-5p and then showed this microRNA to causally associate with…”
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Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus by Jarinova, Olga, Stewart, Alexandre F.R, Roberts, Robert, Wells, George, Lau, Paulina, Naing, Thet, Buerki, Christine, McLean, Bradley W, Cook, Richard C, Parker, Joel S, McPherson, Ruth

“…OBJECTIVES—We have investigated the functional significance of conserved sequences within the 9p21.3 risk locus for coronary artery disease (CAD) and…”
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