Search Results - "McNiff, Patricia"

2‑Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as Potent Dissociated Glucocorticoid Receptor Agonists by Chantigny, Yves A, Murray, John C, Kleinman, Edward F, Robinson, Ralph P, Plotkin, Michael A, Reese, Matthew R, Buckbinder, Leonard, McNiff, Patricia A, Millham, Michele L, Schaefer, Jean F, Abramov, Yuriy A, Bordner, Jon

“…A significant improvement in agonist activity of the previously described 2-aryloctahydrophenanthrene-2,3,7-triol series of dissociated glucocorticoid receptor…”
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Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors by Perregaux, D G, McNiff, P, Laliberte, R, Hawryluk, N, Peurano, H, Stam, E, Eggler, J, Griffiths, R, Dombroski, M A, Gabel, C A

“…Lipopolysaccharide (LPS)-activated monocytes and macrophages produce large quantities of pro-interleukin (IL)-1beta but externalize little mature cytokine…”
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Octahydrophenanthrene-2,7-diol Analogues as Dissociated Glucocorticoid Receptor Agonists: Discovery and Lead Exploration by Robinson, Ralph P, Buckbinder, Leonard, Haugeto, Amber I, McNiff, Patricia A, Millham, Michele L, Reese, Matthew R, Schaefer, Jean F, Abramov, Yuriy A, Bordner, Jon, Chantigny, Yves A, Kleinman, Edward F, Laird, Ellen R, Morgan, Bradley P, Murray, John C, Salter, Eben D, Wessel, Matthew D, Yocum, Sue A

“…As exemplified by the lead compound 2, octahydrophenanthrene-2,7-diol analogues exhibit the profile of a pathway-selective or “dissociated” agonist of the…”
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Quantitative structure-activity relationships of antitumor guanidinothiazolecarboxamides with survival enhancement for therapy in the 3LL Lewis lung carcinoma model by Schnur, Rodney C, Gallaschun, Randall J, Singleton, David H, Grissom, Martin, Sloan, Donald E, Goodwin, Peter, McNiff, Patricia A, Fliri, Anton F. J, Mangano, F. Michael

“…Guanidinothiazolecarboxamides (GTCs) are a novel class of antitumor agents found to be systemically active against experimental pulmonary metastases of 3LL…”
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Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. I. Mechanism and evidence of functional significance by McNiff, P, Svensson, L, Pazoles, CJ, Gabel, CA

“…Tenidap is a novel anti-inflammatory and antiarthritic agent that in clinical studies of rheumatoid arthritis patients, displays symptomatic efficacy superior…”
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LL-Z1271α: An Interleukin-1β Production Inhibitor by Ichikawa, Katsuomi, Inagaki, Taisuke, Kachi-Tonai, Hiroko, Kojima, Yasuhiro, Nakamura, Taka-aki, Nishida, Hiroyuki, Ueno, Yoshinobu, Binding, Peter, Gabel, Christopher A., Lucas, Val, McNiff, Patricia A., Kojima, Nakao

“…LL-Z1271α, a fungal metabolite, dose-dependently inhibited interleukin-1β (IL-1β) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral…”
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Reduction of intracellular pH by tenidap by McNiff, Patricia, Robinson, Ralph P., Gabel, Christopher A.

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Human monocyte ATP-induced IL-1 beta posttranslational processing is a dynamic process dependent on in vitro growth conditions by Laliberte, Ronald E., Perregaux, David G., McNiff, Patricia, Gabel, Christopher A.

“…Despite a large production capacity, freshly isolated lipopolysaccharide (LPS)‐activated human monocytes release only a small percentage of their newly…”
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Inhibition of Cytokine Activation Processes In Vitro by Tenidap, a Novel Anti-Inflammatory Agent by McNiff, Patricia A., Laliberte, Ronald E., Svensson, Linne, Pazoles, Christopher J., Gabel, Christopher A.

“…Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both…”
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Synovial Fluid from Rheumatoid Arthritis Patients Contains Sufficient Levels of IL-1β and IL-6 to Promote Production of Serum Amyloid A By HEP3B Cells by McNiff, Patricia A., Stewart, Caroline, Sullivan, James, Showell, Henry J., Gabel, Christopher A.

“…The presence of positive acute phase proteins within the circulation of rheumatoid arthritis patients suggests that elevated cytokine production associated…”
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Reduction of intracellular pH by tenidap: Involvement of cellular anion transporters in the pH change by McNiff, Patricia, Robinson, Ralph P., Gabel, Christopher A.

“…Tenidap [5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1 H-indole-1-carboxamide], a novel antirheumatic agent, produces a rapid and sustained…”
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An examination of standardized language, mathematics, and reading achievement testing results when compared for middle school -aged student leaders and non-student leaders by McNiff, Susan Patricia Schaming

“…The evolution of the middle school concept, according to Forte and Schurr (2003), with its own identity and its subsequent implementation, has proven to be an…”
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