Search Results - "McNeill, Robert S."

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process by Galvao, Rui Pedro, Kasina, Anita, McNeill, Robert S, Harbin, Jordan E, Foreman, Oded, Verhaak, Roel G W, Nishiyama, Akiko, Miller, C Ryan, Zong, Hui

“…How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed…”
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Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models by Irvin, David M., McNeill, Robert S., Bash, Ryan E., Miller, C. Ryan

“…The influence of cellular origin on glioma pathogenesis remains elusive. We previously showed that mutations inactivating Rb and Pten and activating Kras…”
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PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition by McNeill, Robert S, Stroobant, Emily E, Smithberger, Erin, Canoutas, Demitra A, Butler, Madison K, Shelton, Abigail K, Patel, Shrey D, Limas, Juanita C, Skinner, Kasey R, Bash, Ryan E, Schmid, Ralf S, Miller, C Ryan

“…Glioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense…”
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Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma by Vitucci, Mark, Irvin, David M, McNeill, Robert S, Schmid, Ralf S, Simon, Jeremy M, Dhruv, Harshil D, Siegel, Marni B, Werneke, Andrea M, Bash, Ryan E, Kim, Seungchan, Berens, Michael E, Miller, C Ryan

“…Gliomas are diverse neoplasms with multiple molecular subtypes. How tumor-initiating mutations relate to molecular subtypes as these tumors evolve during…”
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Contemporary murine models in preclinical astrocytoma drug development by McNeill, Robert S, Vitucci, Mark, Wu, Jing, Miller, C Ryan

“…Despite 6 decades of research, only 3 drugs have been approved for astrocytomas, the most common malignant primary brain tumors. However, clinical drug…”
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BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea–Induced Gliomagenesis by McNeill, Robert S, Irvin, David M, Miller, C. Ryan

“…This commentary highlights the article by Wang et al that describes a preclinical model for targeting BRAF-mutant gliomas…”
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Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma by McNeill, Robert S, Canoutas, Demitra A, Stuhlmiller, Timothy J, Dhruv, Harshil D, Irvin, David M, Bash, Ryan E, Angus, Steven P, Herring, Laura E, Simon, Jeremy M, Skinner, Kasey R, Limas, Juanita C, Chen, Xin, Schmid, Ralf S, Siegel, Marni B, Van Swearingen, Amanda E D, Hadler, Michael J, Sulman, Erik P, Sarkaria, Jann N, Anders, Carey K, Graves, Lee M, Berens, Michael E, Johnson, Gary L, Miller, C Ryan

“…Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Prognosis remains poor despite multimodal therapy. Developing alternative treatments…”
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Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer by Van Swearingen, Amanda E D, Sambade, Maria J, Siegel, Marni B, Sud, Shivani, McNeill, Robert S, Bevill, Samantha M, Chen, Xin, Bash, Ryan E, Mounsey, Louisa, Golitz, Brian T, Santos, Charlene, Deal, Allison, Parker, Joel S, Rashid, Naim, Miller, C Ryan, Johnson, Gary L, Anders, Carey K

“…Triple-negative breast cancer (TNBC), lacking expression of hormone and human epidermal growth factor receptor 2 receptors, is an aggressive subtype that…”
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Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide by Schmid, Ralf S, Simon, Jeremy M, Vitucci, Mark, McNeill, Robert S, Bash, Ryan E, Werneke, Andrea M, Huey, Lauren, White, Kristen K, Ewend, Matthew G, Wu, Jing, Miller, C Ryan

“…Glioma stem cells (GSCs) from human glioblastomas (GBMs) are resistant to radiation and chemotherapy and may drive recurrence. Treatment efficacy may depend on…”
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Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis by Vitucci, Mark, Karpinich, Natalie O, Bash, Ryan E, Werneke, Andrea M, Schmid, Ralf S, White, Kristen K, McNeill, Robert S, Huff, Byron, Wang, Sophie, Van Dyke, Terry, Miller, C Ryan

“…Glioblastoma (GBM) genomes feature recurrent genetic alterations that dysregulate core intracellular signaling pathways, including the G1/S cell cycle…”
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Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice by McNeill, Robert S, Schmid, Ralf S, Bash, Ryan E, Vitucci, Mark, White, Kristen K, Werneke, Andrea M, Constance, Brian H, Huff, Byron, Miller, C Ryan

“…Current astrocytoma models are limited in their ability to define the roles of oncogenic mutations in specific brain cell types during disease pathogenesis and…”
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Influence of PI3K and MAPK Pathway Mutations on Response to Mono and Dual Treatment with Targeted Kinase Inhibitors by McNeill, Robert S, Canoutas, Demitra A, Bash, Ryan E, Schmid, Ralf S, Constance, Brian H, Johnson, Gary L, Miller, C. Ryan

“…Abstract only Genetic heterogeneity and drug resistance has hindered the clinical development of targeted kinase inhibitors for treatment of glioblastoma, the…”
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Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process by Galvao, Rui Pedro, Kasina, Anita, McNeill, Robert S., Harbin, Jordan E., Foreman, Oded, Verhaak, Roel G. W., Nishiyama, Akiko, Miller, C. Ryan, Zong, Hui

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ATPS-55INFLUENCE OF MAPK AND PI3K PATHWAY MUTATIONS ON RESPONSE TO TARGETED INHIBITORS by McNeill, Robert S., Canoutas, Demitra A., Schmid, Ralf S., Bash, Ryan E., Constance, Brian H., Azam, Salma H., Reuther, Rachel A., Johnson, Gary L., Miller, C. Ryan

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Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice by McNeill, Robert S., Schmid, Ralf S., Bash, Ryan E., Vitucci, Mark, White, Kristen K., Werneke, Andrea M., Constance, Brian H., Huff, Byron, Miller, C. Ryan

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2000: A COMPUTER ODYSSEY by Shapiro, Allen L., McNeill, Robert S.

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