Search Results - "McNeel, Douglas G."

Androgen deprivation and immunotherapy for the treatment of prostate cancer by Gamat, Melissa, McNeel, Douglas G

“…Prostate cancer is the most common newly diagnosed malignancy in men, and the second most common cause of cancer-related death in the United States. The…”
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Role of B cells as antigen presenting cells by Rastogi, Ichwaku, Jeon, Donghwan, Moseman, Jena E, Muralidhar, Anusha, Potluri, Hemanth K, McNeel, Douglas G

“…B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory…”
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Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma by Choueiri, Toni K, Fishman, Mayer N, Escudier, Bernard, McDermott, David F, Drake, Charles G, Kluger, Harriet, Stadler, Walter M, Perez-Gracia, Jose Luis, McNeel, Douglas G, Curti, Brendan, Harrison, Michael R, Plimack, Elizabeth R, Appleman, Leonard, Fong, Lawrence, Albiges, Laurence, Cohen, Lewis, Young, Tina C, Chasalow, Scott D, Ross-Macdonald, Petra, Srivastava, Shivani, Jure-Kunkel, Maria, Kurland, John F, Simon, Jason S, Sznol, Mario

“…Nivolumab, an anti-PD-1 immune checkpoint inhibitor, improved overall survival versus everolimus in a phase 3 trial of previously treated patients with…”
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Toll-like receptor agonists as cancer vaccine adjuvants by Jeon, Donghwan, Hill, Ethan, McNeel, Douglas G

“…Cancer immunotherapy has emerged as a promising strategy to treat cancer patients. Among the wide range of immunological approaches, cancer vaccines have been…”
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B cells require licensing by dendritic cells to serve as primary antigen-presenting cells for plasmid DNA by Rastogi, Ichwaku, McNeel, Douglas G.

“…DNA vaccines have been an attractive approach for treating cancer patients, however have demonstrated modest immunogenicity in human clinical trials. Dendritic…”
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Molecular Imaging of Immunotherapy Targets in Cancer by Ehlerding, Emily B, England, Christopher G, McNeel, Douglas G, Cai, Weibo

“…Immunotherapy has emerged as a promising alternative in the arsenal against cancer by harnessing the power of the immune system to specifically target…”
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Immunotherapy for prostate cancer: False promises or true hope? by Rekoske, Brian T., McNeel, Douglas G.

“…Prostate cancer is the most commonly diagnosed cancer, and the second leading cause of cancer‐related death for men in the United States. Despite the approval…”
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Toll-like receptor agonist combinations augment mouse T-cell anti-tumor immunity via IL-12- and interferon ß-mediated suppression of immune checkpoint receptor expression by Jeon, Donghwan, McNeel, Douglas G.

“…We previously found that activated CD8 + T-cells increase expression of PD-1, which can be attenuated in the presence of specific Toll-like receptor (TLR)…”
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PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy by Zahm, Christopher D., Moseman, Jena E, Delmastro, Lauren E., G. Mcneel, Douglas

“…Concurrent blockade of different checkpoint receptors, notably PD-1 and CTLA-4, elicits greater anti-tumor activity for some tumor types, and the combination…”
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Targeted Radiation and Immune Therapies-Advances and Opportunities for the Treatment of Prostate Cancer by Muralidhar, Anusha, Potluri, Hemanth K, Jaiswal, Tanya, McNeel, Douglas G

“…Prostate cancer is the most diagnosed malignancy in men in the United States and the second leading cause of cancer-related death. For localized disease,…”
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Long-term follow up of patients treated with a DNA vaccine (pTVG-hp) for PSA-recurrent prostate cancer by Tonelli, Tommaso P, Eickhoff, Jens C, Johnson, Laura E, Liu, Glenn, McNeel, Douglas G

“…We have previously reported two single-agent phase I trials, evaluating the dose or schedule, of a DNA vaccine (pTVG-HP) encoding prostatic acid phosphatase…”
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Sequence of androgen receptor-targeted vaccination with androgen deprivation therapy affects anti-prostate tumor efficacy by Muralidhar, Anusha, Gamat-Huber, Melissa, Vakkalanka, Sita, McNeel, Douglas G

“…RationaleAndrogen deprivation therapy (ADT) is the primary treatment for recurrent and metastatic prostate cancer. In addition to direct antitumor effects, ADT…”
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Safety and Immunological Efficacy of a DNA Vaccine Encoding Prostatic Acid Phosphatase in Patients With Stage D0 Prostate Cancer by MCNEEL, Douglas G, DUNPHY, Edward J, LIU, Glenn, EICKHOFF, Jens C, WILDING, George, DAVIES, James G, FRYE, Thomas P, JOHNSON, Laura E, STAAB, Mary Jane, HORVATH, Dorothea L, STRAUS, Jane, ALBERTI, Dona, MARNOCHA, Rebecca

“…Prostatic acid phosphatase (PAP) is a prostate tumor antigen. We have previously demonstrated that a DNA vaccine encoding PAP can elicit antigen-specific CD8+…”
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Prostate cancer patients on androgen deprivation therapy develop persistent changes in adaptive immune responses by Morse, Matthew D, McNeel, Douglas G

“…Abstract Prostate cancer is a significant cause of morbidity and mortality among men worldwide. The cornerstone treatment for metastatic prostate cancer is…”
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TCR diversity – a universal cancer immunotherapy biomarker? by McNeel, Douglas G.

“…Sipuleucel-T was approved as a treatment for men with advanced metastatic, castration-resistant prostate cancer on the basis of improved survival in randomized…”
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Phase 2 trial of T-cell activation using MVI-816 and pembrolizumab in patients with metastatic, castration-resistant prostate cancer (mCRPC) by McNeel, Douglas G, Eickhoff, Jens C, Wargowski, Ellen, Johnson, Laura E, Kyriakopoulos, Christos E, Emamekhoo, Hamid, Lang, Joshua M, Brennan, Mary Jane, Liu, Glenn

“…BackgroundWe previously reported a trial using a DNA vaccine encoding prostatic acid phosphatase (MVI-816, pTVG-HP), given over 12 weeks concurrently or…”
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The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy by Smith, Heath A., McNeel, Douglas G.

“…Cancer-testis antigens (CTAs) represent an expanding class of tumor-associated proteins defined on the basis of their tissue-restricted expression to testis or…”
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Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles by Sullivan, Jeremy A, AlAdra, David P, Olson, Brian M, McNeel, Douglas G, Burlingham, William J

“…Originally identified as lymphocyte regulation of fellow lymphocytes, our understanding of infectious tolerance has undergone significant evolutions in…”
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Phase 2 trial of a DNA vaccine (pTVG-HP) and nivolumab in patients with castration-sensitive non-metastatic (M0) prostate cancer by McNeel, Douglas G, Emamekhoo, Hamid, Eickhoff, Jens C, Kyriakopoulos, Christos E, Wargowski, Ellen, Tonelli, Tommaso P, Johnson, Laura E, Liu, Glenn

“…PurposeWe have previously reported that a plasmid DNA vaccine encoding prostatic acid phosphatase (pTVG-HP) had greater clinical activity when given in…”
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Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors by Conlon, Kevin, Watson, Dionysios C, Waldmann, Thomas A, Valentin, Antonio, Bergamaschi, Cristina, Felber, Barbara K, Peer, Cody J, Figg, William D, Potter, E Lake, Roederer, Mario, McNeel, Douglas G, Thompson, John A, Gupta, Sumati, Leidner, Rom, Wang-Gillam, Andrea, Parikh, Nehal S, Long, Debby, Kurtulus, Sema, Ho Lee, Lang, Chowdhury, Niladri Roy, Bender, Florent, Pavlakis, George N

“…BackgroundNIZ985 is a recombinant heterodimer of physiologically active interleukin (IL-)15 and IL-15 receptor alpha. In preclinical models, NIZ985 promotes…”
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