Search Results - "McNaughton, Peter"

The TRPM2 ion channel is required for sensitivity to warmth by Tan, Chun-Hsiang, McNaughton, Peter A.

“…Thermally activated ion channels are known to detect the entire thermal range from extreme heat (TRPV2), painful heat (TRPV1, TRPM3 and ANO1), non-painful…”
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The thermo‐TRP ion channel family: properties and therapeutic implications by Vay, Laura, Gu, Chunjing, McNaughton, Peter A

“…The thermo‐transient receptor potentials (TRPs), a recently discovered family of ion channels activated by temperature, are expressed in primary sensory nerve…”
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Heat detection by the TRPM2 ion channel by Vilar, Bruno, Tan, Chun-Hsiang, McNaughton, Peter A.

“…In neurons responding to only one of the agonists for TRPV1, TRPM3 or TRPA1 (Extended Data Fig. 2a), 2-APB caused a small reduction in thermal response…”
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Opioid-Induced Hyperalgesia and Tolerance Are Driven by HCN Ion Channels by Han, Xue, Pinto, Larissa Garcia, Vilar, Bruno, McNaughton, Peter A

“…Prolonged exposure to opioids causes an enhanced sensitivity to painful stimuli (opioid-induced hyperalgesia, OIH) and a need for increased opioid doses to…”
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Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150 by Zhang, Xuming, Li, Lin, McNaughton, Peter A.

“…The ability of vertebrates to detect and avoid damaging extremes of temperature depends on activation of ion channels belonging to the thermo-TRP family…”
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HCN3 ion channels: roles in sensory neuronal excitability and pain by Lainez, Sergio, Tsantoulas, Christoforos, Biel, Martin, McNaughton, Peter A

“…Key points HCN ion channels conducting the Ih current control the frequency of firing in peripheral sensory neurons signalling pain. Previous studies have…”
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Omenn Syndrome can Occur during Enzyme Therapy for Adenosine Deaminase Deficiency by Forbes, Elizabeth M., McNaughton, Peter B.

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Omenn syndrome: A rare manifestation of severe combined immunodeficiency masquerading as drug reaction with eosinophilia and systemic symptoms by Forbes, Elizabeth M, McNaughton, Peter B

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Direct inhibition of the cold-activated TRPM8 ion channel by Gαq by Zhang, Xuming, Mak, Stephanie, Li, Lin, Parra, Andres, Denlinger, Bristol, Belmonte, Carlos, McNaughton, Peter A.

“…Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of pleasant coolness. Here we show that inflammatory mediators such as…”
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HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain by Emery, Edward C., Young, Gareth T., Berrocoso, Esther M., Chen, Lubin, McNaughton, Peter A.

“…The rate of action potential firing in nociceptors is a major determinant of the intensity of pain. Possible modulators of action potential firing include the…”
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Sensitization of TRPA1 by Protein Kinase A by Meents, Jannis E, Fischer, Michael J M, McNaughton, Peter A

“…The TRPA1 ion channel is expressed in nociceptive (pain-sensitive) somatosensory neurons and is activated by a wide variety of chemical irritants, such as…”
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Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length by Swire, Matthew, Assinck, Peggy, McNaughton, Peter A, Lyons, David A, Ffrench-Constant, Charles, Livesey, Matthew R

“…Oligodendrocytes generate myelin sheaths vital for the formation, health, and function of the CNS. Myelin sheath length is a key property that determines…”
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Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy by Tsantoulas, Christoforos, Laínez, Sergio, Wong, Sara, Mehta, Ishita, Vilar, Bruno, McNaughton, Peter A

“…Diabetic patients frequently suffer from continuous pain that is poorly treated by currently available analgesics. We used mouse models of type 1 and type 2…”
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HCN2 Ion Channels Drive Pain in Rodent Models of Migraine by Tsantoulas, Christoforos, Ng, Aidan, Pinto, Larissa, Andreou, Anna P, McNaughton, Peter A

“…Migraine is believed to be initiated by neuronal activity in the CNS, that triggers excitation of nociceptive trigeminal ganglion (TG) nerve fibers innervating…”
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TRPM2 and warmth sensation by Tan, Chun-Hsiang, McNaughton, Peter A.

“…The abilities to detect warmth and heat are critical for the survival of all animals, both in order to be able to identify suitable thermal environments for…”
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TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide by Morad, Hassan, Luqman, Suaib, Tan, Chun-Hsiang, Swann, Victoria, McNaughton, Peter A.

“…Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen…”
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STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons by Buijs, Tamara J, Vilar, Bruno, Tan, Chun‐Hsiang, McNaughton, Peter A

“…Moderate coolness is sensed by TRPM8 ion channels in peripheral sensory nerves, but the mechanism by which noxious cold is detected remains elusive. Here, we…”
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Prostaglandin E2 depolarises sensory axons in vitro in an ANO1 and Nav1.8 dependent manner by Kimourtzis, Georgios, Rangwani, Natasha, Jenkins, Bethan J., Jani, Siddharth, McNaughton, Peter A., Raouf, Ramin

“…Prostaglandin E2 (PGE2) is a major contributor to inflammatory pain hyperalgesia, however, the extent to which it modulates the activity of nociceptive axons…”
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Activation of the TRPV4 Ion Channel Is Enhanced by Phosphorylation by Fan, Hueng-Chuen, Zhang, Xuming, McNaughton, Peter A.

“…The TRPV4 (transient receptor potential vanilloid 4) ion channel, a member of the vanilloid subfamily of the transient receptor potential channels, is…”
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NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels by Zhang, Xuming, Huang, Jiehong, McNaughton, Peter A

“…Nociceptors, or pain‐sensitive receptors, are unique among sensory receptors in that their sensitivity is increased by noxious stimulation. This process,…”
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