Search Results - "McNaughton, Amy J M"

Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis by Cook, Elina K., Izukawa, Terumi, Young, Sherylan, Rosen, Gili, Jamali, Mina, Zhang, Liying, Johnson, Dylan, Bain, Eva, Hilland, Jamie, Ferrone, Christina K., Buckstein, Jonah, Francis, Janika, Momtaz, Bushra, McNaughton, Amy J.M., Liu, Xudong, Snetsinger, Brooke, Buckstein, Rena, Rauh, Michael J.

“…•CH may be associated with broader ill health (worse performance status, increased and potentially novel comorbidities).•Serum interleukin-6 is elevated in…”
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Interplay between maternal Slc6a4 mutation and prenatal stress: a possible mechanism for autistic behavior development by Sjaarda, Calvin P., Hecht, Patrick, McNaughton, Amy J. M., Zhou, Audrina, Hudson, Melissa L., Will, Matt J., Smith, Garth, Ayub, Muhammad, Liang, Ping, Chen, Nansheng, Beversdorf, David, Liu, Xudong

“…The low activity allele of the maternal polymorphism, 5HTTLPR, in the serotonin transporter, SLC6A4 , coupled with prenatal stress is reported to increase the…”
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Exome sequencing identifies de novo splicing variant in XRCC6 in sporadic case of autism by Sjaarda, Calvin P, Wood, Shalandra, McNaughton, Amy J M, Taylor, Sarah, Hudson, Melissa L, Liu, Xudong, Guerin, Andrea, Ayub, Muhammad

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with heterogeneity in presentation, genetic etiology, and clinical outcome. Although…”
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Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease by Vlasschaert, Caitlyn, McNaughton, Amy J M, Chong, Michael, Cook, Elina K, Hopman, Wilma, Kestenbaum, Bryan, Robinson-Cohen, Cassianne, Garland, Jocelyn, Moran, Sarah M, Paré, Guillaume, Clase, Catherine M, Tang, Mila, Levin, Adeera, Holden, Rachel, Rauh, Michael J, Lanktree, Matthew B

“…Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem…”
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A Lower Frequency of Spliceosome Mutations Distinguishes Clonal Cytopenias of Undetermined Significance From Low-Risk Myelodysplastic Syndromes, Despite Inherent Similarities in Genomic, Laboratory, and Clinical Features by Ferrone, Christina K., McNaughton, Amy J.M., Rashedi, Iran, Ring, Brooke, Buckstein, Rena, Tsui, Hubert, Rauh, Michael J.

“…Clonal cytopenias of undetermined significance (CCUS) are associated with an increased risk of developing a myelodysplastic syndrome (MDS); however, the…”
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Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function by Quin, Candice, DeJong, Erica N, Cook, Elina K, Luo, Yi Zhen, Vlasschaert, Caitlyn, Sadh, Sanathan, McNaughton, Amy Jm, Buttigieg, Marco M, Breznik, Jessica A, Kennedy, Allison E, Zhao, Kevin, Mewburn, Jeffrey, Dunham-Snary, Kimberly J, Hindmarch, Charles Ct, Bick, Alexander G, Archer, Stephen L, Rauh, Michael J, Bowdish, Dawn Me

“…Individuals with clonal hematopoiesis of indeterminate potential (CHIP) are at increased risk of aging related health conditions and all-cause mortality, but…”
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Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability by Heidari, Abolfazl, Tongsook, Chanakan, Najafipour, Reza, Musante, Luciana, Vasli, Nasim, Garshasbi, Masoud, Hu, Hao, Mittal, Kirti, McNaughton, Amy J M, Sritharan, Kumudesh, Hudson, Melissa, Stehr, Henning, Talebi, Saeid, Moradi, Mohammad, Darvish, Hossein, Arshad Rafiq, Muhammad, Mozhdehipanah, Hossein, Rashidinejad, Ali, Samiei, Shahram, Ghadami, Mohsen, Windpassinger, Christian, Gillessen-Kaesbach, Gabriele, Tzschach, Andreas, Ahmed, Iltaf, Mikhailov, Anna, Stavropoulos, D James, Carter, Melissa T, Keshavarz, Soraya, Ayub, Muhammad, Najmabadi, Hossein, Liu, Xudong, Ropers, Hans Hilger, Macheroux, Peter, Vincent, John B

“…Histamine (HA) acts as a neurotransmitter in the brain, which participates in the regulation of many biological processes including inflammation, gastric acid…”
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Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion by Quin, Candice, DeJong, Erica N., McNaughton, Amy J. M., Buttigieg, Marco M., Basrai, Salman, Abelson, Sagi, Larché, Maggie J., Rauh, Michael J., Bowdish, Dawn M. E.

“…•The inflammatory microenvironment that accompanies aging, and specifically TNF, favors TET2-mutant myeloid expansion.•Therapeutic blockage of TNF may be a…”
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U2AF1 S34/Q157 Variants Detected in cis Arise Sequentially in an MDS Patient With Serial Sequencing Spanning 18 Years by Ferrone, Christina K., McNaughton, Amy J. M., Vincelli, Felicia, Zuzarte, Philip, Lee, David, Feilotter, Harriet E., Rauh, Michael J.

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U2AF1S34/Q157 Variants Detected in cis Arise Sequentially in an MDS Patient With Serial Sequencing Spanning 18 Years by Ferrone, Christina K., McNaughton, Amy J. M., Vincelli, Felicia, Zuzarte, Philip, Lee, David, Feilotter, Harriet E., Rauh, Michael J.

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De novo duplication on chromosome 19 observed in nuclear family displaying neurodevelopmental disorders by Sjaarda, Calvin P, Kaiser, Beatrice, McNaughton, Amy Jm, Hudson, Melissa L, Harris-Lowe, Liam, Lou, Kyle, Guerin, Andrea, Ayub, Muhammad, Liu, Xudong

“…Pleiotropy and variable expressivity have been cited to explain the seemingly distinct neurodevelopmental disorders due to a common genetic etiology within the…”
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Noninvasive Prenatal Detection of Trisomy 21 by Targeted Semiconductor Sequencing: A Technical Feasibility Study by Xi, Yanwei, Arbabi, Aryan, McNaughton, Amy J M, Hamilton, Alison, Hull, Danna, Perras, Helene, Chiu, Tillie, Morrison, Shawna, Goldsmith, Claire, Creede, Emilie, Anger, Gregory J, Honeywell, Christina, Cloutier, Mireille, Macchio, Natasha, Kiss, Courtney, Liu, Xudong, Crocker, Susan, Davies, Gregory A, Brudno, Michael, Armour, Christine M

“…To develop an alternate noninvasive prenatal testing method for the assessment of trisomy 21 (T21) using a targeted semiconductor sequencing approach. A…”
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Chronic TNF in the Aging Microenvironment Exacerbates TET2-loss-of-Function Myeloid Expansion by Quin, Candice, DeJong, Erica, McNaughton, Amy J. M., Buttigieg, Marco M., Basrai, Salman, Abelson, Sagi, Larche, Margaret, Rauh, Michael J., Bowdish, Dawn ME

“…Introduction: Age-associated TET2 somatic mutations impart an intrinsic hematopoietic stem cell (HSC) advantage and contribute to the phenomenon of clonal…”
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The Impact of Clonal Hematopoiesis on Clinical Outcomes and Clonal Dynamics in Older Lymphoma Patients Receiving Chemotherapy by Buckstein, Rena, Lopes, Olivia, McNaughton, Amy J. M., Cheung, Matthew C., Mozessohn, Lee, Chodirker, Lisa, Imrie, Kevin, Berinstein, Neil, Chow, Signy, Kupakuwana-Suk, Gillian, Parmentier, Anne, Sasitharakumar, Prasha, Tsui, Hubert, Zhang, Liying, Rauh, Michael J.

“…Background: CHIP is more commonly encountered in cancer patients, such as those with lymphoma, than in the general population likely attributable to age,…”
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Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD by Sjaarda, Calvin P., Sabbagh, Mark, Wood, Shalandra, Ward-King, Jessica, McNaughton, Amy J.M., Hudson, Melissa L., Tao, Mingda, Ayub, Muhammad, Liu, Xudong

“…•Individuals with ASD and their undiagnosed relatives present similar EEG responses.•COMT and OXTR polymorphisms not associated with any specific EEG…”
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Clinical Utility of Hematopathologist-Triaged NGS Testing When Investigating Patients with Suspected MDS by Ferrone, Christina K, McNaughton, Amy JM, Rashedi, Iran, Tsui, Hubert, Rauh, Michael J

“…The recognition of MDS is challenging in early stages, where diagnosis may rely solely upon morphological criteria for dysplasia, a non-specific finding prone…”
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CCUS and Low-Risk MDS Are Inherently Similar, Sharing Clonal and Clinical Features by Ferrone, Christina K, McNaughton, Amy JM, Rashedi, Iran, Buckstein, Rena, Tsui, Hubert, Rauh, Michael J

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Impact of temperature on the expression of Kennedy Pathway genes in developing soybean seeds by McNaughton, Amy J. M., Shelp, Barry J., Rajcan, Istvan

“…McNaughton, A. J. M., Shelp, B. J. and Rajcan, I. 2015. Impact of temperature on the expression of Kennedy Pathway genes in developing soybean seeds. Can. J…”
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Impact of temperature on the expression of Kennedy Pathway genes in developing soybean seeds by McNaughton, Amy J. M, Shelp, Barry J, Rajcan, Istvan

“…McNaughton, A. J. M., Shelp, B. J. and Rajcan, I. 2015. Impact of temperature on the expression of Kennedy Pathway genes in developing soybean seeds. Can. J…”
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