Search Results - "McNaught, Kevin St.P."

Proteasomal function is impaired in substantia nigra in Parkinson's disease by McNaught, Kevin St.P, Jenner, Peter

“…The accumulation of α-synuclein, ubiquitin and other proteins in Lewy bodies in degenerating dopaminergic neurones in substantia nigra in idiopathic…”
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Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation by McNaught, Kevin St.P, Jenner, Peter

“…Dopaminergic neuronal death in substantia nigra in Parkinson’s disease is accompanied by depletion of reduced glutathione levels and inhibition of complex I…”
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Toxicity to PC12 cells of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by McNaught, Kevin St.P., Thull, Ulrike, Carrupt, Pierre-Alain, Altomare, Cosimo, Cellamare, Saverio, Carotti, Angelo, Testa, Bernard, Jenner, Peter, Marsden, C. David

“…Isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or 1-methyl-4-phenylpyridinium (MPP +) are inhibitors of…”
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Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson's disease by McNaught, Kevin St.P, Belizaire, Roger, Jenner, Peter, Olanow, C.Warren, Isacson, Ole

“…The proteolytic activities of 26/20S proteasomes are impaired in the substantia nigra pars compacta (SNc) in sporadic Parkinson's disease (PD). In the present…”
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The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease by Mcnaught, Kevin St.P., Jnobaptiste, Ruth, Jackson, Tehone, Jengelley, Toni-Ann

“…The basis of neuronal vulnerability, degeneration, and sparing in PD are unknown, but there is increasing evidence to suggest that the ubiquitin‐proteasome…”
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Proteolytic dysfunction in neurodegenerative disorders by McNaught, Kevin St P

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Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson’s disease by McNaught, Kevin St.P., Carrupt, Pierre-Alain, Altomare, Cosimo, Cellamare, Saverio, Carotti, Angelo, Testa, Bernard, Jenner, Peter, Marsden, C.David

“…The cause of neurodegeneration in Parkinson’s disease (PD) remains unknown. However, isoquinoline derivatives structurally related to the selective…”
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Dysfunction of rat forebrain astrocytes in culture alters cytokine and neurotrophic factor release by McNaught, Kevin St.P, Jenner, Peter

“…Altered glial cell function occurring in substantia nigra in Parkinson’ disease may lead to the release of cytokines and impairment of neurotrophic factor…”
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Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) by McNaught, Kevin ST.P., Thull, Ulrike, Carrupt, Pierre-Alain, Altomare, Cosimo, Cellamare, Saverio, Carotti, Angelo, Testa, Bernard, Jenner, Peter, Marsden, C.David

“…Mitochondrial respiratory failure secondary to complex I inhibition may contribute to the neurode-generative process underlying nigral cell death in…”
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Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration by McNaught, Kevin St.P., Thull, Ulrike, Carrupt, Pierre-Alain, Altomare, Cosimo, Cellamare, Saverio, Carotti, Angelo, Testa, Bernard, Jenner, Peter, Marsden, C.David

“…Isoquinoline derivatives exert 1-methyl-4-phenylpyridinium (MPP +)-like activity as inhibitors of complex I and α-ketoglutarate dehydrogenase activity in rat…”
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Nitric oxide causes release of glutamate from brain synaptosomes by McNaught, K S, Brown, G C

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Inhibition of [ 3H]dopamine uptake into striatal synaptosomes by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by McNaught, Kevin St.P., Thull, Ulrike, Carrupt, Pierre-Alain, Altomare, Cosimo, Cellamare, Saverio, Carotti, Angelo, Testa, Bernard, Jenner, Peter, Marsden, C.David

“…Isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP +) may be endogenous…”
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Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by McNaught, K S, Altomare, C, Cellamare, S, Carotti, A, Thull, U, Carrupt, P A, Testa, B, Jenner, P, Marsden, C D

“…Defects in complex I and alpha-ketoglutarate dehydrogenase (alpha-KGDH) occur in the substantia nigra in Parkinson's disease (PD). Isoquinoline derivatives…”
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Nigral Cell Loss Produced by Infusion of Isoquinoline Derivatives Structurally Related to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by McNaught, Kevin St.P., Thull, Ulrike, Carrupt, Pierre-Alain, Altomare, Cosimo, Cellamare, Saverio, Carotti, Angelo, Testa, Bernard, Jenner, Peter, Marsden, C.David

“…Isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6Ndash;tetrahydropyridine or 1-methyl-4-phenylpyridinium (MPP +) are potential…”
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