Search Results - "McNamara, Molly C."

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex by McNamara, Molly C., Hosios, Aaron M., Torrence, Margaret E., Zhao, Ting, Fraser, Cameron, Wilkinson, Meghan, Kwiatkowski, David J., Henske, Elizabeth P., Wu, Chin-Lee, Sarosiek, Kristopher A., Valvezan, Alexander J., Manning, Brendan D.

“…mTORC1 is aberrantly activated in cancer and in the genetic tumor syndrome tuberous sclerosis complex (TSC), which is caused by loss-of-function mutations in…”
Get full text

BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance by Ferretti, Roberta, Bhutkar, Arjun, McNamara, Molly C, Lees, Jacqueline A

“…Melanoma can switch between proliferative and invasive states, which have identifying gene expression signatures that correlate with good and poor prognosis,…”
Get full text

mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability by Valvezan, Alexander J., Turner, Marc, Belaid, Amine, Lam, Hilaire C., Miller, Spencer K., McNamara, Molly C., Baglini, Christian, Housden, Benjamin E., Perrimon, Norbert, Kwiatkowski, David J., Asara, John M., Henske, Elizabeth P., Manning, Brendan D.

“…The mechanistic target of rapamycin complex 1 (mTORC1) supports proliferation through parallel induction of key anabolic processes, including protein, lipid,…”
Get full text

mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species by Hosios, Aaron M., Wilkinson, Meghan E., McNamara, Molly C., Kalafut, Krystle C., Torrence, Margaret E., Asara, John M., Manning, Brendan D.

“…The mechanistic target of rapamycin complex 1 (mTORC1) senses and relays environmental signals from growth factors and nutrients to metabolic networks and…”
Get full text

IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex by Valvezan, Alexander J, McNamara, Molly C, Miller, Spencer K, Torrence, Margaret E, Asara, John M, Henske, Elizabeth P, Manning, Brendan D

“…Recent studies in distinct preclinical tumor models have established the nucleotide synthesis enzyme inosine-5'-monophosphate dehydrogenase (IMPDH) as a viable…”
Get full text