Search Results - "McNamara, Dan E."

Computational design of self-assembling cyclic protein homo-oligomers by Fallas, Jorge A., Ueda, George, Sheffler, William, Nguyen, Vanessa, McNamara, Dan E., Sankaran, Banumathi, Pereira, Jose Henrique, Parmeggiani, Fabio, Brunette, T. J., Cascio, Duilio, Yeates, Todd R., Zwart, Peter, Baker, David

“…Self-assembling cyclic protein homo-oligomers play important roles in biology, and the ability to generate custom homo-oligomeric structures could enable new…”
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Structural basis of BAK activation in mitochondrial apoptosis initiation by Singh, Geetika, Guibao, Cristina D., Seetharaman, Jayaraman, Aggarwal, Anup, Grace, Christy R., McNamara, Dan E., Vaithiyalingam, Sivaraja, Waddell, M. Brett, Moldoveanu, Tudor

“…BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming BCL-2 Effector BAK is activated remains incompletely understood…”
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Accurate design of co-assembling multi-component protein nanomaterials by King, Neil P., Bale, Jacob B., Sheffler, William, McNamara, Dan E., Gonen, Shane, Gonen, Tamir, Yeates, Todd O., Baker, David

“…The self-assembly of proteins into highly ordered nanoscale architectures is a hallmark of biological systems. The sophisticated functions of these molecular…”
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MLKL Requires the Inositol Phosphate Code to Execute Necroptosis by Dovey, Cole M., Diep, Jonathan, Clarke, Bradley P., Hale, Andrew T., McNamara, Dan E., Guo, Hongyan, Brown, Nathaniel W., Cao, Jennifer Yinuo, Grace, Christy R., Gough, Peter J., Bertin, John, Dixon, Scott J., Fiedler, Dorothea, Mocarski, Edward S., Kaiser, William J., Moldoveanu, Tudor, York, John D., Carette, Jan E.

“…Necroptosis is an important form of lytic cell death triggered by injury and infection, but whether mixed lineage kinase domain-like (MLKL) is sufficient to…”
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Geometric Lessons and Design Strategies for Nanoscale Protein Cages by Laniado, Joshua, Cannon, Kevin A, Miller, Justin E, Sawaya, Michael R, McNamara, Dan E, Yeates, Todd O

“…Protein molecules bring a rich functionality to the field of designed nanoscale architectures. High-symmetry protein cages are rapidly finding diverse…”
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Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis by Zheng, Janet H., Grace, Christy R., Guibao, Cristina D., McNamara, Dan E., Llambi, Fabien, Wang, Yue-Ming, Chen, Taosheng, Moldoveanu, Tudor

“…The effector B cell lymphoma-2 (BCL-2) protein BCL-2 ovarian killer (BOK) induces mitochondrial outer membrane permeabilization (MOMP) to initiate apoptosis…”
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Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites by McNamara, Dan E, Dovey, Cole M, Hale, Andrew T, Quarato, Giovanni, Grace, Christy R, Guibao, Cristina D, Diep, Jonathan, Nourse, Amanda, Cai, Casey R, Wu, Hong, Kalathur, Ravi C, Green, Douglas R, York, John D, Carette, Jan E, Moldoveanu, Tudor

“…Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like…”
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Alanine Scanning Mutagenesis Identifies an Asparagine–Arginine–Lysine Triad Essential to Assembly of the Shell of the Pdu Microcompartment by Sinha, Sharmistha, Cheng, Shouqiang, Sung, Yea Won, McNamara, Dan E., Sawaya, Michael R., Yeates, Todd O., Bobik, Thomas A.

“…Bacterial microcompartments (MCPs) are the simplest organelles known. They function to enhance metabolic pathways by confining several related enzymes inside…”
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Structures of potent anticancer compounds bound to tubulin by McNamara, Dan E., Senese, Silvia, Yeates, Todd O., Torres, Jorge Z.

“…Small molecules that bind to tubulin exert powerful effects on cell division and apoptosis (programmed cell death). Cell‐based high‐throughput screening…”
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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis by McNamara, Dan E, Quarato, Giovanni, Guy, Cliff S, Green, Douglas R, Moldoveanu, Tudor

“…Necroptosis is a programmed cell death pathway triggered by activation of receptor interacting protein kinase 3 (RIPK3), which phosphorylates and activates the…”
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Structure of Dihydromethanopterin Reductase, a Cubic Protein Cage for Redox Transfer by McNamara, Dan E., Cascio, Duilio, Jorda, Julien, Bustos, Cheene, Wang, Tzu-Chi, Rasche, Madeline E., Yeates, Todd O., Bobik, Thomas A.

“…Dihydromethanopterin reductase (Dmr) is a redox enzyme that plays a key role in generating tetrahydromethanopterin (H4MPT) for use in one-carbon metabolism by…”
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Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids by Nash, Rebekah P., McNamara, Dan E., Keith Ballentine III, W., Matson, Steven W., Redinbo, Matthew R.

“…► Bisphosphonates and related compounds variably affect conjugative plasmid transfer. ► Conjugation of plasmids R100, pCU1 and F are differentially impacted by…”
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Functional Characterization of the Multidomain F Plasmid TraI Relaxase-Helicase by Cheng, Yuan, McNamara, Dan E., Miley, Michael J., Nash, Rebekah P., Redinbo, Matthew R.

“…TraI, a bifunctional enzyme containing relaxase and helicase activities, initiates and drives the conjugative transfer of the Escherichia coli F plasmid. Here,…”
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RMT focal plane sensitivity to seismic network geometry and faulting style by Johnson, Kendra L., Hayes, Gavin P., Herrmann, Robert B., Benz, Harley M., McNamara, Dan E., Bergman, Eric

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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis by McNamara, Dan E., Quarato, Giovanni, Guy, Cliff S., Green, Douglas R., Moldoveanu, Tudor

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Structures of potent anticancer compounds bound to tubulin by McNamara, Dan E., Senese, Silvia, Yeates, Todd O., Torres, Jorge Z.

“…Abstract Small molecules that bind to tubulin exert powerful effects on cell division and apoptosis (programmed cell death). Cell‐based high‐throughput…”
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Accurate design of coassembling multi-component protein nanomaterials by King, Neil P., Bale, Jacob B., Sheffler, William, McNamara, Dan E., Gonen, Shane, Gonen, Tamir, Yeates, Todd O., Baker, David

“…The self-assembly of proteins into highly ordered nanoscale architectures is a hallmark of biological systems. The sophisticated functions of these molecular…”
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Symmetry-Based Design and Structure of Self-Assembling Protein Cages and Nanomaterials by Lai, Yen-Ting, King, Neil P., Sheffler, William, McNamara, Dan E., Bale, Jacob B., Baker, David, Yeates, Todd O.

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