Search Results - "McNamara, DJ"

Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis by Howell, WH, McNamara, DJ, Tosca, MA, Smith, BT, Gaines, JA

“…Quantitative relations between dietary fat and cholesterol and plasma lipid concentrations have been the subject of much study and some controversy during the…”
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Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6 by Toogood, Peter L, Harvey, Patricia J, Repine, Joseph T, Sheehan, Derek J, VanderWel, Scott N, Zhou, Hairong, Keller, Paul R, McNamara, Dennis J, Sherry, Debra, Zhu, Tong, Brodfuehrer, Joanne, Choi, Chung, Barvian, Mark R, Fry, David W

“…A pharmacological approach to inhibition of cyclin-dependent kinases 4 and 6 (Cdk4/6) using highly selective small molecule inhibitors has the potential to…”
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Dietary cholesterol and atherosclerosis by McNamara, Donald J

“…The perceived relationship between dietary cholesterol, plasma cholesterol and atherosclerosis is based on three lines of evidence: animal feeding studies,…”
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Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4 by VanderWel, Scott N, Harvey, Patricia J, McNamara, Dennis J, Repine, Joseph T, Keller, Paul R, Quin, John, Booth, R. John, Elliott, William L, Dobrusin, Ellen M, Fry, David W, Toogood, Peter L

“…Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases…”
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Specific, Irreversible Inactivation of the Epidermal Growth Factor Receptor and erbB2, by a New Class of Tyrosine Kinase Inhibitor by Fry, David W., Bridges, Alexander J., Denny, William A., Doherty, Annette, Greis, Kenneth D., Hicks, James L., Hook, Kenneth E., Keller, Paul R., Leopold, Wilbur R., Loo, Joseph A., McNamara, Dennis J., Nelson, James M., Sherwood, Veronika, Smaill, Jeff B., Trumpp-Kallmeyer, Susanne, Dobrusin, Ellen M.

“…A class of high-affinity inhibitors is disclosed that selectively target and irreversibly inactivate the epidermal growth factor receptor tyrosine kinase…”
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Regulation of guinea pig plasma low density lipoprotein kinetics by dietary fat saturation by Fernandez, ML, Lin, EC, McNamara, DJ

“…Dietary fat saturation has been shown to affect hepatic apoB/E receptor expression and to modify low density lipoprotein (LDL) composition and density in…”
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Guar gum effects on plasma low-density lipoprotein and hepatic cholesterol metabolism in guinea pigs fed low- and high-cholesterol diets: a dose-response study by Fernandez, ML, Sun, DM, Tosca, M, McNamara, DJ

“…Guinea pigs were fed semipurified diets containing either 0% or 12.5% guar gum (GG) with 0.04% cholesterol or increasing concentrations of GG (0%, 2.5%, 5%,…”
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Differential effects of saturated fatty acids on low density lipoprotein metabolism in the guinea pig by Fernandez, ML, Lin, EC, McNamara, DJ

“…Studies have shown that dietary fat saturation affects guinea pig plasma low density lipoprotein (LDL) levels by altering both LDL receptor-mediated catabolism…”
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Tyrosine Kinase Inhibitors. 18. 6-Substituted 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Soluble, Irreversible Inhibitors of the Epidermal Growth Factor Receptor by Smaill, Jeff B, Showalter, H. D. Hollis, Zhou, Hairong, Bridges, Alexander J, McNamara, Dennis J, Fry, David W, Nelson, James M, Sherwood, Veronika, Vincent, Patrick W, Roberts, Bill J, Elliott, William L, Denny, William A

“…4-Anilinoquinazoline- and 4-anilinopyrido[3,4-d]pyrimidine-6-acrylamides are potent pan-erbB tyrosine kinase inactivators, and one example (CI-1033) is in…”
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Eggs and heart disease risk: perpetuating the misperception by McNamara, Donald J

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Protein Tyrosine Phosphatase Substrate Specificity: Size and Phosphotyrosine Positioning Requirements in Peptide Substrates by Zhang, Zhong Yin, Maclean, Derek, McNamara, Dennis J, Sawyer, Tomi K, Dixon, Jack E

“…The structural requirements of substrates for two recombinant protein tyrosine phosphatases (PTPases) are probed using various-sized synthetic phosphotyrosine…”
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Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases by Singh, Juswinder, Dobrusin, Ellen M, Fry, David W, Haske, Taraneh, Whitty, Adrian, McNamara, Dennis J

“…We report the use of structure-based drug design to create a selective erbB-1 (a.k.a. epidermal growth factor receptor) and erbB-2 (a.k.a. neu/her2 growth…”
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Exercise improves plasma lipid profiles and modifies lipoprotein composition in guinea pigs by Ensign, Wayne Y, McNamara, Donald J, Fernandez, Maria Luz

“…These studies were conducted to determine the effects of exercise training on plasma lipoprotein levels and metabolism in the guinea pig to evaluate potential…”
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A geometric algebra reformulation of geometric optics by Sugon, Quirino M., McNamara, Daniel J.

“…We present a tutorial on the Clifford (geometric) algebra Cl 3,0 and use it to reformulate the laws of geometric optics. This algebra is essentially a Pauli…”
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Substrate Specificity of the Protein Tyrosine Phosphatases by Zhang, Zhong-Yin, Thieme-Sefler, Andrea M., Maclean, Derek, McNamara, Dennis J., Dobrusin, Ellen M., Sawyer, Tomi K., Dixon, Jack E.

“…The substrate specificity of a recombinant protein tyrosine phosphatase (PTPase) was probed using synthetic phosphotyrosine-containing peptides corresponding…”
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The relationship of dietary fat to plasma lipid levels as studied by factor analysis of adipose tissue fatty acid composition in a free-living population of middle-aged American men by Berry, EM, Hirsch, J, Most, J, McNamara, DJ, Thornton, J

“…We have used adipose tissue biopsies to assess the quality of fat in the diet and its influence on plasma lipid levels in 413 free-living normolipidemic male…”
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Cholesteryl ester transfer protein and lecithin: Cholesterol acyltransferase activities in hispanic and anglo postmenopausal women: Associations with total and regional body fat by Greaves, Kathryn A., Going, Scott B., Fernandez, Maria Luz, Milliken, Laura A., Lohman, Timothy G., Bassford, Tamsen, McNamara, Donald J.

“…Reverse cholesterol transport is one process by which high-density lipoprotein (HDL) cholesterol has been hypothesized to play a role in reducing the risk of…”
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Prickly pear (Opuntia sp.) pectin alters hepatic cholesterol metabolism without affecting cholesterol absorption in guinea pigs fed a hypercholesterolemic diet by Fernandez, M L, Lin, E C, Trejo, A, McNamara, D J

“…Prickly pear pectin intake decreases plasma LDL concentrations by increasing hepatic apolipoprotein B/E receptor expression in guinea pigs fed a…”
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Prickly pear (Opuntia sp.) pectin reverses low density lipoprotein receptor suppression induced by a hypercholesterolemic diet in guinea pigs by Fernandez, M L, Lin, E C, Trejo, A, McNamara, D J

“…The effects of prickly pear pectin on plasma LDL metabolism were investigated by feeding guinea pigs either a diet containing 15 g/100 g lard and 0.25 g/100 g…”
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The Impact of Egg Limitations on Coronary Heart Disease Risk: Do the Numbers Add Up? by McNamara, Donald J

“…For over 25 years eggs have been the icon for the fat, cholesterol and caloric excesses in the American diet, and the message to limit eggs to lower heart…”
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