Search Results - "McNamara, Coleen A."

Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis by Doran, Amanda C, Meller, Nahum, McNamara, Coleen A

“…The initiation of atherosclerosis results from complex interactions of circulating factors and various cell types in the vessel wall, including endothelial…”
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Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis by Alencar, Gabriel F., Owsiany, Katherine M., Karnewar, Santosh, Sukhavasi, Katyayani, Mocci, Giuseppe, Nguyen, Anh T., Williams, Corey M., Shamsuzzaman, Sohel, Mokry, Michal, Henderson, Christopher A., Haskins, Ryan, Baylis, Richard A., Finn, Aloke V., McNamara, Coleen A., Zunder, Eli R., Venkata, Vamsidhar, Pasterkamp, Gerard, Björkegren, Johan, Bekiranov, Stefan, Owens, Gary K.

“…Rupture and erosion of advanced atherosclerotic lesions with a resultant myocardial infarction or stroke are the leading worldwide cause of death. However, we…”
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Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas by Zernecke, Alma, Winkels, Holger, Cochain, Clément, Williams, Jesse W., Wolf, Dennis, Soehnlein, Oliver, Robbins, Clint S., Monaco, Claudia, Park, Inhye, McNamara, Coleen A., Binder, Christoph J., Cybulsky, Myron I., Scipione, Corey A., Hedrick, Catherine C., Galkina, Elena V., Kyaw, Tin, Ghosheh, Yanal, Dinh, Huy Q., Ley, Klaus

“…The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9 single-cell RNA sequencing and 2 mass cytometry studies. In a…”
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Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry by Hamers, Anouk A.J, Dinh, Huy Q, Thomas, Graham D, Marcovecchio, Paola, Blatchley, Amy, Nakao, Catherine S, Kim, Cheryl, McSkimming, Chantel, Taylor, Angela M, Nguyen, Anh T, McNamara, Coleen A, Hedrick, Catherine C

“…OBJECTIVE—Three distinct human monocyte subsets have been identified based on the surface marker expression of CD14 and CD16. We hypothesized that monocytes…”
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Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis by Gaddis, Dalia E., Padgett, Lindsey E., Wu, Runpei, McSkimming, Chantel, Romines, Veronica, Taylor, Angela M., McNamara, Coleen A., Kronenberg, Mitchell, Crotty, Shane, Thomas, Michael J., Sorci-Thomas, Mary G., Hedrick, Catherine C.

“…Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here we show that during atherogenesis Treg cells lose Foxp3…”
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B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis by Rosenfeld, Sam M, Perry, Heather M, Gonen, Ayelet, Prohaska, Thomas A, Srikakulapu, Prasad, Grewal, Sukhdeep, Das, Deepanjana, McSkimming, Chantel, Taylor, Angela M, Tsimikas, Sotirios, Bender, Timothy P, Witztum, Joseph L, McNamara, Coleen A

“…RATIONALE:B cells contribute to atherosclerosis through subset-specific mechanisms. Whereas some controversy exists about the role of B-2 cells, B-1a cells are…”
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Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis by Marcovecchio, Paola M, Thomas, Graham D, Mikulski, Zbigniew, Ehinger, Erik, Mueller, Karin A.L, Blatchley, Amy, Wu, Runpei, Miller, Yury I, Nguyen, Anh Tram, Taylor, Angela M, McNamara, Coleen A, Ley, Klaus, Hedrick, Catherine C

“…OBJECTIVE—Nonclassical monocytes (NCM) function to maintain vascular homeostasis by crawling or patrolling along the vessel wall. This subset of monocytes…”
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Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance by Harmon, Daniel B, Srikakulapu, Prasad, Kaplan, Jennifer L, Oldham, Stephanie N, McSkimming, Chantel, Garmey, James C, Perry, Heather M, Kirby, Jennifer L, Prohaska, Thomas A, Gonen, Ayelet, Hallowell, Peter, Schirmer, Bruce, Tsimikas, Sotirios, Taylor, Angela M, Witztum, Joseph L, McNamara, Coleen A

“…OBJECTIVE—Little is known about the role(s) B cells play in obesity-induced metabolic dysfunction. This study used a mouse with B-cell–specific deletion of Id3…”
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Lymphocytes and the Adventitial Immune Response in Atherosclerosis by Campbell, Kirsti A, Lipinski, Michael J, Doran, Amanda C, Skaflen, Marcus D, Fuster, Valentin, McNamara, Coleen A

“…Although much of the research on atherosclerosis has focused on the intimal accumulation of lipids and inflammatory cells, there is an increasing amount of…”
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Pre-operative aerobic exercise on metabolic health and surgical outcomes in patients receiving bariatric surgery: A pilot trial by Gilbertson, Nicole M, Gaitán, Julian M, Osinski, Victoria, Rexrode, Elizabeth A, Garmey, James C, Mehaffey, J Hunter, Hassinger, Taryn E, Kranz, Sibylle, McNamara, Coleen A, Weltman, Arthur, Hallowell, Peter T, Malin, Steven K

“…Examine if adding aerobic exercise to standard medical care (EX+SC) prior to bariatric surgery improves metabolic health in relation to surgical outcomes…”
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B-Cell Depletion Promotes Aortic Infiltration of Immunosuppressive Cells and Is Protective of Experimental Aortic Aneurysm by Schaheen, Basil, Downs, Emily A, Serbulea, Vlad, Almenara, Camila C.P, Spinosa, Michael, Su, Gang, Zhao, Yunge, Srikakulapu, Prasad, Butts, Cherié, McNamara, Coleen A, Leitinger, Norbert, Upchurch, Gilbert R, Meher, Akshaya K, Ailawadi, Gorav

“…OBJECTIVE—B-cell depletion therapy is widely used for treatment of cancers and autoimmune diseases. B cells are abundant in abdominal aortic aneurysms (AAA);…”
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Single Cell High Dimensional Analysis of Human Peripheral Blood Mononuclear Cells Reveals Unique Intermediate Monocyte Subsets Associated with Sex Differences in Coronary Artery Disease by Chatterjee, Nandini, Komaravolu, Ravi K, Durant, Christopher P, Wu, Runpei, McSkimming, Chantel, Drago, Fabrizio, Kumar, Sunil, Valentin-Guillama, Gabriel, Miller, Yury I, McNamara, Coleen A, Ley, Klaus, Taylor, Angela, Alimadadi, Ahmad, Hedrick, Catherine C

“…Monocytes are associated with human cardiovascular disease progression. Monocytes are segregated into three major subsets: classical (cMo), intermediate (iMo),…”
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BAFF neutralization impairs the autoantibody-mediated clearance of dead adipocytes and aggravates obesity-induced insulin resistance by Lempicki, Melissa D, Gray, Jake A, Abuna, Gabriel, Murata, Ramiro M, Divanovic, Senad, McNamara, Coleen A, Meher, Akshaya K

“…B cell-activating factor (BAFF) is a critical TNF-family cytokine that regulates homeostasis and peripheral tolerance of B2 cells. BAFF overproduction promotes…”
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Single-cell profiling of CD11c+ B cells in atherosclerosis by Pattarabanjird, Tanyaporn, Srikakulapu, Prasad, Ransegnola, Brett, Marshall, Melissa A, Ghosheh, Yanal, Gulati, Rishab, Durant, Chistopher, Drago, Fabrizio, Taylor, Angela M, Ley, Klaus, McNamara, Coleen A

“…Circulating CD11c+ B cells, a novel subset of activated B cells, have been linked to autoimmunity and shown to expand with age. Atherosclerosis is an…”
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Sex Differences in Coronary Artery Disease and Diabetes Revealed by scRNA-Seq and CITE-Seq of Human CD4+ T Cells by Saigusa, Ryosuke, Vallejo, Jenifer, Gulati, Rishab, Suthahar, Sujit Silas Armstrong, Suryawanshi, Vasantika, Alimadadi, Ahmad, Makings, Jeffrey, Durant, Christopher P, Freuchet, Antoine, Roy, Payel, Ghosheh, Yanal, Pandori, William, Pattarabanjird, Tanyaporn, Drago, Fabrizio, Taylor, Angela, McNamara, Coleen A, Shemesh, Avishai, Lanier, Lewis L, Hedrick, Catherine C, Ley, Klaus

“…Despite the decades-old knowledge that males and people with diabetes mellitus (DM) are at increased risk for coronary artery disease (CAD), the reasons for…”
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Chemokine Receptor-6 Promotes B-1 Cell Trafficking to Perivascular Adipose Tissue, Local IgM Production and Atheroprotection by Srikakulapu, Prasad, Upadhye, Aditi, Drago, Fabrizio, Perry, Heather M, Bontha, Sai Vineela, McSkimming, Chantel, Marshall, Melissa A, Taylor, Angela M, McNamara, Coleen A

“…Chemokine receptor-6 (CCR6) mediates immune cell recruitment to inflammatory sites and has cell type-specific effects on diet-induced atherosclerosis in mice…”
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Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity by Dennis, Emily, Murach, Maria, Blackburn, Cassidy M R, Marshall, Melissa, Root, Katherine, Pattarabanjird, Tanyaporn, Deroissart, Justine, Erickson, Loren D, Binder, Christoph J, Bekiranov, Stefan, McNamara, Coleen A

“…Recent studies have demonstrated a role for Ten-Eleven Translocation-2 (TET2), an epigenetic modulator, in regulating germinal center formation and plasma cell…”
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Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells by Srikakulapu, Prasad, Upadhye, Aditi, Rosenfeld, Sam M, Marshall, Melissa A, McSkimming, Chantel, Hickman, Alexandra W, Mauldin, Ileana S, Ailawadi, Gorav, Lopes, M Beatriz S, Taylor, Angela M, McNamara, Coleen A

“…Adipose tissue surrounding major arteries (Perivascular adipose tissue or PVAT) has long been thought to exist to provide vessel support and insulation…”
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Single cell transcriptomics reveals recent CD8T cell receptor signaling in patients with coronary artery disease by Iqneibi, Shahad, Saigusa, Ryosuke, Khan, Amir, Oliaeimotlagh, Mohammad, Armstrong Suthahar, Sujit Silas, Kumar, Sunil, Alimadadi, Ahmad, Durant, Christopher P, Ghosheh, Yanal, McNamara, Coleen A, Hedrick, Catherine C, Ley, Klaus

“…Coronary artery disease (CAD) is a major cause of death worldwide. The role of CD8+ T cells in CAD is unknown. Recent studies suggest a breakdown of tolerance…”
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Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2 by Zhou, Jing, Li, Xiaogang, Luo, Ying, Starremans, Patrick G, McNamara, Coleen A, Pei, York

“…Autosomal-dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is characterized by progressive cyst formation and…”
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