Search Results - "McNally, James J."

Diabetogenic Effect of a Series of Tricyclic Delta Opioid Agonists Structurally Related to Cyproheptadine by Codd, Ellen E., Baker, Judith, Brandt, Michael R., Bryant, Stewart, Cai, Chaozhong, Carson, John R., Chevalier, Kristen M., Colburn, Raymond W., Coogan, Timothy P., Dax, Scott L., DeCorte, Bart, Kemmerer, Michael, LeGrand, Edmund K., Lenhard, James M., Leone, Angelique M., Lin, Ling, Mabus, John R., McDonnell, Mark E., McMillian, Michael K., McNally, James J., Stone, Dennis J., Wang, Charles Y., Zhang, Sui-Po, Flores, Christopher M.

“…The unexpected observation of a hyperglycemic effect of some tricycle-based delta opioid receptor (DOR) agonists led to a series of studies to better…”
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Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists by Matthews, Jay M., McNally, James J., Connolly, Peter J., Xia, Mingde, Zhu, Bin, Black, Shawn, Chen, Cailin, Hou, Cuifen, Liang, Yin, Tang, Yuting, Macielag, Mark J.

“…[Display omitted] A series of potent and receptor-selective cannabinoid-1 (CB1) receptor inverse agonists has been discovered. Peripheral selectivity of the…”
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The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists by Matthews, Jay M., Qin, Ning, Colburn, Raymond W., Dax, Scott L., Hawkins, Mike, McNally, James J., Reany, Laura, Youngman, Mark A., Baker, Judith, Hutchinson, Tasha, Liu, Yi, Lubin, Mary Lou, Neeper, Michael, Brandt, Michael R., Stone, Dennis J., Flores, Christopher M.

“…The synthesis and structure–activity relationships of a series of potent benzothiophene-based phosphonates, exemplied by 9l, are reported. A series of…”
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Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1 by Jetter, Michele C., Youngman, Mark A., McNally, James J., McDonnell, Mark E., Zhang, Sui-Po, Dubin, Adrienne E., Nasser, Nadia, Codd, Ellen E., Flores, Christopher M., Dax, Scott L.

“…The synthesis and biological activity of a series of aminotetralin-derived heteroaryl urea TRPV1 antagonists is reported. We report on a series of…”
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Mannich reactions of resin-bound substrates: 2. A versatile three-component solid-phase organic synthesis methodology by McNally, James J., Youngman, Mark A., Dax, Scott L.

“…Alkynes, secondary amines and aldehydes, in the presence of a copper (I) salt, undergo Mannich reactions to afford the corresponding aminomethylalkynyl adducts…”
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N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1) by Jetter, Michele C., McNally, James J., Youngman, Mark A., McDonnell, Mark E., Dubin, Adrienne E., Nasser, Nadia, Zhang, Sui-Po, Codd, Ellen E., Colburn, Ray W., Stone, Dennis R., Brandt, Michael R., Flores, Christopher M., Dax, Scott L.

“…The synthesis and biological activity of a series of 3-quinolinyl p-aminobenzamide TRPV1 antagonists are reported. High throughput screening of our compound…”
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N-Isoquinolin-5-yl- N′-aralkyl-urea and -amide antagonists of human vanilloid receptor 1 by Jetter, Michele C., Youngman, Mark A., McNally, James J., Zhang, Sui-Po, Dubin, Adrienne E., Nasser, Nadia, Dax, Scott L.

“…N-Isoquinolin-5-yl- N′-aralkyl-ureas and -amides were developed as potent ligands of human vanilloid receptor 1. N-Isoquinolin-5-yl-…”
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Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor by Kordik, Cheryl P, Luo, Chi, Zanoni, Brian C, Dax, Scott L, McNally, James J, Lovenberg, Timothy W, Wilson, Sandy J, Reitz, Allen B

“…1,3-Disubstituted-5-aminopyrazoles were prepared based on a lead compound found through high-throughput screening of our corporate compound library in an assay…”
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α-Substituted N-(Sulfonamido)alkyl-β-aminotetralins:  Potent and Selective Neuropeptide Y Y5 Receptor Antagonists by Youngman, Mark A, McNally, James J, Lovenberg, Timothy W, Reitz, Allen B, Willard, Nicole M, Nepomuceno, Diane H, Wilson, Sandy J, Crooke, Jeffrey J, Rosenthal, Daniel, Vaidya, Anil H, Dax, Scott L

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N-Acylated α-(3-pyridylmethyl)-β-aminotetralin antagonists of the human neuropeptide Y Y5 receptor by McNally, James J, Youngman, Mark A, Lovenberg, Timothy W, Nepomuceno, Diane, Wilson, Sandy, Dax, Scott L

“…α-(3-Pyridylmethyl)-β-aminotetralins were acylated with amino-piperidinyl and-pyrrolidinyl acetic acids, and with (aminomethyl)cyclohexanecarboxylic acid…”
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Thiophene systems. 9. Thienopyrimidinedione derivatives as potential antihypertensive agents by Russell, Ronald K, Press, Jeffery B, Rampulla, Richard A, McNally, James J, Falotico, Robert, Keiser, Joan A, Bright, David A, Tobia, Alfonso

“…A series of thieno[3,4-d]-, thieno[3,2-d]-, and thieno[2,3-d]pyrimidine-2,4-diones with (phenylpiperazinyl)alkyl substitution at N-3 have been synthesized and…”
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Thiophene systems. 14. Synthesis and antihypertensive activity of novel 7-(cyclic amido)-6-hydroxythieno[3,2-b]pyrans and related compounds as new potassium channel activators by Sanfilippo, Pauline J, McNally, James J, Press, Jeffery B, Fitzpatrick, Louis J, Urbanski, Maud J, Katz, Laurence B, Giardino, Edward, Falotico, Robert, Salata, Joseph

“…The synthesis and antihypertensive activity of novel 7-(cyclic amido)-6-hydroxy-5,5-dimethylthieno[3,2-b]pyrans and related compounds are described. The…”
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An Unusually Selective Diels-Alder Dimerization of a [4n + 2] Electrocyclic Ring-Opened Thieno[3,2-b]pyran by Press, Jeffery B, Sorgi, Kirk L, McNally, James J, Leo, Gregory C

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Thiophene systems. 16. Interesting contrasts in electrocyclic reactions for thieno[3,2-b]- and -[2,3-b]pyrans with chromenes by Turchi, Ignatius J, Press, Jeffery B, McNally, James J, Bonner, Mary Pat, Sorgi, Kirk L

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Investigations into a mild Diels-Alder approach to 6-substituted quinazoline-2,4-dione derivatives by McNally, James J, Press, Jeffery B

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Multi-component methodologies in solid-phase organic synthesis by Dax, S L, McNally, J J, Youngman, M A

“…Solid-phase organic synthesis, particularly when used in conjunction with combinatorial techniques, is emerging as a revolutionary technology in chemistry…”
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Cardiotonic agents. Synthesis and inotropic activity of a series of isoquinolin-3-ol derivatives by Kanojia, Ramesh M, Press, Jeffery B, Lever, O. William, Williams, Louella, McNally, James J, Tobia, Alfonso J, Falotico, Robert, Moore, John B

“…A series of isoquinolin-3-ol derivatives (II) was prepared as analogues of the clinical cardiotonic agent bemarinone (ORF 16600, I). Although in many respects…”
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Optical coatings deposited using ion assisted deposition by McNally, James J., Jungling, K. C., Williams, F. L., McNeil, J. R.

“…The properties of Ta2O5 and Al2O3 optical coatings deposited using oxygen‐ion assisted deposition (IAD) were investigated. Previously,1 we reported preliminary…”
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Corrigendum to “ N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1)” [Bioorg. Med. Chem. Lett. 18 (2008) 2730–2734] by Jetter, Michele C., McNally, James J., Youngman, Mark A., McDonnell, Mark E., Dubin, Adrienne E., Nasser, Nadia, Zhang, Sui-Po, Codd, Ellen E., Colburn, Ray W., Stone, Dennis R., Brandt, Michael R., Flores, Christopher M., Dax, Scott L.

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The Synthesis of Novel cis-α-Substituted-β-aminotetralins by Youngman, Mark A., Willard, Nicole M., Dax, Scott L., McNally, James J.

“…Teteralones were converted, in 1 to 3 steps, to α-substituted tetralones. Subsequent reductive amination with ammonium acetate/sodium cyanoborohydride gave the…”
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