Search Results - "McNair, Chris"

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair by Shafi, Ayesha A., McNair, Chris M., McCann, Jennifer J., Alshalalfa, Mohammed, Shostak, Anton, Severson, Tesa M., Zhu, Yanyun, Bergman, Andre, Gordon, Nicolas, Mandigo, Amy C., Chand, Saswati N., Gallagher, Peter, Dylgjeri, Emanuela, Laufer, Talya S., Vasilevskaya, Irina A., Schiewer, Matthew J., Brunner, Michael, Feng, Felix Y., Zwart, Wilbert, Knudsen, Karen E.

“…Mechanisms regulating DNA repair processes remain incompletely defined. Here, the circadian factor CRY1, an evolutionally conserved transcriptional…”
Get full text

Subsets of cancer cells expressing CX3CR1 are endowed with metastasis-initiating properties and resistance to chemotherapy by DiNatale, Anthony, Kaur, Ramanpreet, Qian, Chen, Zhang, Jieyi, Marchioli, Michael, Ipe, Darin, Castelli, Maria, McNair, Chris M., Kumar, Gaurav, Meucci, Olimpia, Fatatis, Alessandro

“…Metastasis-initiating cells (MICs) display stem cell-like features, cause metastatic recurrences and defy chemotherapy, which leads to patients’ demise. Here…”
Get full text

Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer by Mandigo, Amy C, Shafi, Ayesha A, McCann, Jennifer J, Yuan, Wei, Laufer, Talya S, Bogdan, Denisa, Gallagher, Lewis, Dylgjeri, Emanuela, Semenova, Galina, Vasilevskaya, Irina A, Schiewer, Matthew J, McNair, Chris M, de Bono, Johann S, Knudsen, Karen E

“…The retinoblastoma tumor suppressor (RB) is a critical regulator of E2F-dependent transcription, controlling a multitude of protumorigenic networks including…”
Get full text

RB Loss Promotes Prostate Cancer Metastasis by Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, Haber, Alex, Ertel, Adam, Bhardwaj, Anshul, Addya, Sankar, Williams, Noelle, Ciment, Stephen J, Cotzia, Paolo, Dean, Jeffry L, Snook, Adam, McNair, Chris, Price, Matt, Hernandez, James R, Zhao, Shuang G, Birbe, Ruth, McCarthy, James B, Turley, Eva A, Pienta, Kenneth J, Feng, Felix Y, Dicker, Adam P, Knudsen, Karen E, Den, Robert B

“…RB loss occurs commonly in neoplasia but its contributions to advanced cancer have not been assessed directly. Here we show that RB loss in multiple murine…”
Get full text

Abstract 5217: RB loss reprograms AR and E2F1 signaling in models of prostate cancer progression by Mandigo, Amy C., McNair, Chris, Schiewer, Matthew J., Knudsen, Karen E.

“…Abstract Prostatic adenocarcinoma (PCa) is the most frequently diagnosed non-cutaneous malignancy, and the third leading cause of cancer death in males in the…”
Get full text

Abstract 4511: Prostate cancer-specific enrichment of TP53 missense mutations elicits differential, context-dependent biochemical and biologic outcomes by McCann, Jennifer J., Vasilevskaya, Irina, PoudelNeupane, Neermala, Dean, Jeffry, Mandigo, Amy, Leeuw, Renee De, McNair, Chris, Schiewer, Matthew, Knudsen, Karen

“…Abstract Prostatic adenocarcinoma (PCa) remains the second leading cause of cancer death in men in the United States. While organ-confined disease can be…”
Get full text

Abstract LB-A29: Divergent mechanisms of transcriptional regulation by SAGA member and epigenetic modifier USP22 by Butt, Sabrina, Stanek, Timothy J., Gennaro, Victoria J., McNair, Chris, Pauley, Kristen L., Knudsen, Karen, McMahon, Steven B.

“…Abstract SAGA is a 2 MDa multi-subunit complex containing two assembly modules (TAF and SPT) and two enzymatic modules (HAT and DUB) which exhibit…”
Get full text

Abstract B11: Re-wired E2F function in response to RB loss as a potential driver of castration-resistant prostate cancer by Mandigo, Amy C., McNair, Chris, Schiewer, Matthew J., Xu, Kexin, Li, Fugen, Myles, Brown, Knudsen, Karen E.

“…Abstract Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous malignancy, and second leading cause of cancer death in males in the United…”
Get full text