Search Results - "McMurray, A. A"
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Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect
Published in Cell (26-06-2009)“…Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here, we…”
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Septin Filament Formation Is Essential in Budding Yeast
Published in Developmental cell (19-04-2011)“…Septins are GTP-binding proteins that form ordered, rod-like multimeric complexes and polymerize into filaments, but how such supramolecular structure…”
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Unlocking the black box of HPWPs-performance relationship in Vietnamese higher education context: the case of Ho Chi Minh City's universities
Published in Studies in higher education (Dorchester-on-Thames) (02-09-2023)“…Resting on social exchange theory and the Ability-Motivation-Opportunity framework, this research examined the causal relationships between high-performance…”
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Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation
Published in The Journal of cell biology (12-12-2011)“…Septins are conserved guanosine triphosphate-binding cytoskeletal proteins involved in membrane remodeling. In budding yeast, five mitotic septins (Cdc3,…”
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Phosphatidylinositol -4,5- bisphosphate Promotes Budding Yeast Septin Filament Assembly and Organization
Published in Journal of molecular biology (10-12-2010)“…Septins are a conserved family of GTP-binding proteins that assemble into symmetric linear heterooligomeric complexes, which in turn are able to polymerize…”
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Saccharomyces cerevisiae septins: Supramolecular organization of heterooligomers and the mechanism of filament assembly
Published in Proceedings of the National Academy of Sciences - PNAS (17-06-2008)“…Mitotic yeast cells express five septins (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1/Sep7). Only Shs1 is nonessential. The four essential septins form a complex…”
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Septins: molecular partitioning and the generation of cellular asymmetry
Published in Cell division (26-08-2009)“…During division, certain cellular contents can be distributed unequally; daughter cells with different fates have different needs. Septins are proteins that…”
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Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeast
Published in G3 : genes - genomes - genetics (06-09-2021)“…Life requires the oligomerization of individual proteins into higher-order assemblies. In order to form functional oligomers, monomers must adopt appropriate…”
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Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast
Published in Molecular biology of the cell (01-04-2015)“…Septin hetero-oligomers polymerize into cytoskeletal filaments with essential functions in many eukaryotic cell types. Mutations within the oligomerization…”
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Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast
Published in eLife (28-01-2020)“…Septin proteins evolved from ancestral GTPases and co-assemble into hetero-oligomers and cytoskeletal filaments. In , five septins comprise two species of…”
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An Age-Induced Switch to a Hyper-Recombinational State
Published in Science (American Association for the Advancement of Science) (26-09-2003)“…There is a strong correlation between age and cancer, but the mechanism by which this phenomenon occurs is unclear. We chose Saccharomyces cerevisiae to…”
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Assembly, molecular organization, and membrane-binding properties of development-specific septins
Published in The Journal of cell biology (29-02-2016)“…Septin complexes display remarkable plasticity in subunit composition, yet how a new subunit assembled into higher-order structures confers different functions…”
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Source regions contributing to excess reactive nitrogen deposition in the Greater Yellowstone Area (GYA) of the United States
Published in Atmospheric chemistry and physics (10-09-2018)“…Research has shown that excess reactive nitrogen (Nr) deposition in the Greater Yellowstone Area (GYA) of the United States has passed critical load (CL)…”
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Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling
Published in Proceedings of the National Academy of Sciences - PNAS (29-06-2010)“…During response of budding yeast to peptide mating pheromone, the cell becomes markedly polarized and MAPK scaffold protein Ste5 localizes to the resulgint…”
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Chemical rescue of mutant proteins in living Saccharomyces cerevisiae cells by naturally occurring small molecules
Published in G3 : genes - genomes - genetics (01-09-2021)“…Intracellular proteins function in a complex milieu wherein small molecules influence protein folding and act as essential cofactors for enzymatic reactions…”
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Septin Stability and Recycling during Dynamic Structural Transitions in Cell Division and Development
Published in Current biology (26-08-2008)“…Septins are conserved proteins found in hetero-oligomeric complexes that are incorporated into distinct structures during cell division and differentiation;…”
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Emergency tracheostomy management cognitive aid
Published in Anaesthesia and intensive care (01-05-2021)“…Tracheostomies may be inserted to assist weaning from ventilation or to aid airway management.1 Complications occur in up to 40% of patients, with tube…”
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Coupling de novo protein folding with subunit exchange into pre-formed oligomeric protein complexes: the ‘heritable template’ hypothesis
Published in Biomolecular concepts (01-12-2016)“…Despite remarkable advances in synthetic biology, the fact remains that it takes a living cell to make a new living cell. The information encoded in the genome…”
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DNAdigest and Repositive: Connecting the World of Genomic Data
Published in PLoS biology (24-03-2016)“…There is no unified place where genomics researchers can search through all available raw genomic data in a way similar to OMIM for genes or Uniprot for…”
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The DNA sequence of human chromosome 22
Published in Nature (London) (02-12-1999)“…Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides…”
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