Search Results - "McMullen, W"

Neuroprotection in the Treatment of Acute Ischemic Stroke by Patel, Rajan A.G, McMullen, Paul W

“…Abstract Neuroprotection remains one of the holy grails of acute ischemic stroke therapy. The ability to protect the ischemic brain from injury until…”
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Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment by Venkatraman, Ganesh, Benesch, Matthew G. K., Tang, Xiaoyun, Dewald, Jay, McMullen, Todd P. W., Brindley, David N.

“…The present work elucidates novel mechanisms for lysophosphatidate (LPA)‐induced chemoresistance using human breast, lung, liver, and thyroid cancer cells. LPA…”
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Tumor‐induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression by Benesch, Matthew G. K., Tang, Xiaoyun, Dewald, Jay, Dong, Wei‐Feng, Mackey, John R., Hemmings, Denise G., McMullen, Todd P. W., Brindley, David N.

“…ABSTRACT Compared to normal tissues, many cancer cells overexpress autotaxin (ATX). This secreted enzyme produces extracellular lysophosphatidate, which…”
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Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance by Bekele, Raie T., Venkatraman, Ganesh, Liu, Rong-Zong, Tang, Xiaoyun, Mi, Si, Benesch, Matthew G. K., Mackey, John R., Godbout, Roseline, Curtis, Jonathan M., McMullen, Todd P. W., Brindley, David N.

“…Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as…”
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Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice by Benesch, Matthew G. K., Tang, Xiaoyun, Maeda, Tatsuo, Ohhata, Akira, Zhao, Yuan Y., Kok, Bernard P. C., Dewald, Jay, Hitt, Mary, Curtis, Jonathan M., McMullen, Todd P. W., Brindley, David N.

“…ABSTRACT Autotaxin is a secreted enzyme that produces most extracellular lysophosphatidate, which stimulates 6 G‐protein‐coupled receptors. Lysophosphatidate…”
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PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling by Yang, Zelei, Tang, Xiaoyun, McMullen, Todd P. W., Brindley, David N., Hemmings, Denise G.

“…Human cytomegalovirus (HCMV) infects 40–70% of adults in developed countries. HCMV proteins and DNA are detected in tumors and metastases, suggesting an…”
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Dexamethasone decreases the autotaxin‐lysophosphatidate‐inflammatory axis in adipose tissue: implications for the metabolic syndrome and breast cancer by Meng, Guanmin, Tang, Xiaoyun, Yang, Zelei, Zhao, Yuan Yuan, Curtis, Jonathan M., Mcmullen, Todd P. W., Brindley, David N.

“…ABSTRACT Lysophosphatidate (LPA) signaling through 6 receptors is regulated by the balance of LPA production by autotaxin (ATX) vs. LPA degradation by lipid…”
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Comparative transcriptomics and eQTL mapping of response to Melampsora americana in selected Salix purpurea F2 progeny by Wilkerson, Dustin G, Crowell, Chase R, Carlson, Craig H, McMullen, Patrick W, Smart, Christine D, Smart, Lawrence B

“…Melampsora spp. rusts are the greatest pathogen threat to shrub willow (Salix spp.) bioenergy crops. Genetic resistance is key to limit the effects of these…”
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Newly identified breast luminal progenitor and gestational stem cell populations likely give rise to HER2-overexpressing and basal-like breast cancers by McMullen, James R. W., Soto, Ubaldo

“…Breast Cancer (BrC) is a common malignancy with genetically diverse subtypes. There is evidence that specific BrC subtypes originate from particular normal…”
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Hyperparathyroidism in Pregnancy: Options for Localization and Surgical Therapy by McMullen, Todd P. W., Learoyd, Diana L., Williams, David C., Sywak, Mark S., Sidhu, Stan B., Delbridge, Leigh W.

“…Background Hyperparathyroidism in pregnancy is a threat to the health of both mother and fetus. The mothers suffer commonly from nephrolithiasis, hyperemesis,…”
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Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer by Benesch, Matthew G K, Ko, Yi M, Tang, Xiaoyun, Dewald, Jay, Lopez-Campistrous, Ana, Zhao, Yuan Y, Lai, Raymond, Curtis, Jonathan M, Brindley, David N, McMullen, Todd P W

“…Autotaxin is a secreted enzyme that converts extracellular lysophosphatidylcholine to lysophosphatidate (LPA). In cancers, LPA increases tumour growth,…”
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Laparoscopic hysterectomy for endometrial cancer: impact of age on clinical outcomes by Ee, W. W., Nellore, V., McMullen, W., Ragupathy, K.

“…Introduction: Improvement in preoperative care for the ageing population has resulted in an increasing number of elderly patients to be considered for surgery…”
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The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells by Ortiz-Hernandez, Greisha L., Sanchez-Hernandez, Evelyn S., Ochoa, Pedro T., Elix, Catherine C., Alkashgari, Hossam R., McMullen, James R. W., Soto, Ubaldo, Martinez, Shannalee R., Diaz Osterman, Carlos J., Mahler, Michael, Roy, Sourav, Casiano, Carlos A.

“…Patients with prostate cancer (PCa) receiving docetaxel chemotherapy invariably develop chemoresistance. The transcription co-activator lens epithelium-derived…”
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The utility of thyroid ultrasonography in the management of thyroid nodules by Gamme, Gary, MD, Williams, David C., MD, McMullen, Todd P.W., MD, PhD, Wiebe, Edward, MD, Ghosh, Sunita, PhD, Litt, Brendan, MD, Parrington, Tyler, MD

“…Background Ultrasonography for thyroid nodules is one of the most common imaging tests performed in the general population. Details from ultrasound reports…”
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Poster 197-C Epidemiology of Cervical Spine Injuries in High School Athletes by Meron, Adele, MD, McMullen, Christopher W., MD, Laker, Scott R., MD, Comstock, R. Dawn, PhD

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Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy by Meng, Guanmin, Tang, Xiaoyun, Yang, Zelei, Benesch, Matthew G. K., Marshall, Alison, Murray, David, Hemmings, Denise G., Wuest, Frank, McMullen, Todd P. W., Brindley, David N.

“…ABSTRACT We have previously established that adipose tissue adjacent to breast tumors becomes inflamed by tumor‐derived cytokines. This stimulates autotaxin…”
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Gene expression profile of epithelial-mesenchymal transition mediators in papillary thyroid cancer by Lopez-Campistrous, Ana, Adewuyi, Esther Ekpe, Williams, David C., McMullen, Todd P. W.

“…Purpose Platelet derived growth receptor alpha (PDGFRA) promotes the epithelial-mesenchymal transition (EMT) in thyroid follicular cells and is linked to…”
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Positron Emission Tomography Imaging of Autotaxin in Thyroid and Breast Cancer Models Using [18F]PRIMATX by Litchfield, Marcus, Wuest, Melinda, Glubrecht, Daryl, Briard, Emmanuelle, Auberson, Yves P, McMullen, Todd P. W, Brindley, David N, Wuest, Frank

“…Autotaxin (ATX) is a secreted enzyme responsible for producing lysophosphatidic acid (LPA). The ATX/LPA signaling axis is typically activated in wound healing…”
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Advancing the Taxonomy of Disability in Older Adults by Leveille, Suzanne G., Fried, Linda P., McMullen, William, Guralnik, Jack M.

“…Background. Refinement of the traditional task-based classification of disability is needed to advance the field of disability research and to inform clinical…”
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Practical considerations around using Xpert® HPV in low-income countries, focusing on Malawi by Heather Cubie, R. ter Haar, D. Morton, S. Kafwafwa, B. Kabota, B. Mdetsa, H. Chauwa, E. Kawonga, M. Mautanga, I. Mwenitete, N. Teakle, R. Nkhoma, C. Campbell, L. Grant, I. Bruce, H. Brown, G. Walker, M. Deeny, G. Stanczuk, W. McMullen

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