Search Results - "McMullen, Megan R."

Absence of receptor interacting protein kinase 3 prevents ethanol‐induced liver injury by Roychowdhury, Sanjoy, McMullen, Megan R., Pisano, Sorana G., Liu, Xiuli, Nagy, Laura E.

“…Hepatocyte cell death via apoptosis and necrosis are major hallmarks of ethanol‐induced liver injury. However, inhibition of apoptosis is not sufficient to…”
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Prophylactic tributyrin treatment mitigates chronic‐binge ethanol‐induced intestinal barrier and liver injury by Cresci, Gail A, Glueck, Bryan, McMullen, Megan R, Xin, Wei, Allende, Daniella, Nagy, Laura E

“…Background and Aim Impaired gut‐liver axis is a potential factor contributing to alcoholic liver disease. Ethanol depletes intestinal integrity and causes gut…”
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Receptor interacting protein 3 protects mice from high‐fat diet‐induced liver injury by Roychowdhury, Sanjoy, McCullough, Rebecca L., Sanz‐Garcia, Carlos, Saikia, Paramananda, Alkhouri, Naim, Matloob, Ammar, Pollard, Katherine A., McMullen, Megan R., Croniger, Colleen M., Nagy, Laura E.

“…Multiple pathways of programmed cell death are important in liver homeostasis. Hepatocyte death is associated with progression of nonalcoholic fatty liver…”
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The non-transcriptional activity of IRF3 modulates hepatic immune cell populations in acute-on-chronic ethanol administration in mice by Sanz-Garcia, Carlos, Poulsen, Kyle L., Bellos, Damien, Wang, Han, McMullen, Megan R., Li, Xiaoxia, Chattopadhyay, Saurabh, Sen, Ganes, Nagy, Laura E.

“…[Display omitted] •Interferon regulatory factor 3 (IRF3) has both transcriptional and non-transcriptional activity.•Gao-binge ethanol exposure increases both…”
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Alcohol-induced autophagy contributes to loss in skeletal muscle mass by Thapaliya, Samjhana, Runkana, Ashok, McMullen, Megan R, Nagy, Laura E, McDonald, Christine, Prasad, Sathyamangla V Naga, Dasarathy, Srinivasan

“…Patients with alcoholic cirrhosis and hepatitis have severe muscle loss. Since ethanol impairs skeletal muscle protein synthesis but does not increase…”
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IRAKM‐Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease by Zhou, Hao, Yu, Minjia, Zhao, Junjie, Martin, Bradley N., Roychowdhury, Sanjoy, McMullen, Megan R., Wang, Emily, Fox, Paul L., Yamasaki, Sho, Nagy, Laura E., Li, Xiaoxia

“…Lipopolysaccharide (LPS)‐mediated activation of Toll‐like receptors (TLRs) in hepatic macrophages and injury to hepatocytes are major contributors to the…”
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Hepatic kinome atlas: An in‐depth identification of kinase pathways in liver fibrosis of humans and rodents by Creeden, Justin F., Kipp, Zachary A., Xu, Mei, Flight, Robert M., Moseley, Hunter N. B., Martinez, Genesee J., Lee, Wang‐Hsin, Alganem, Khaled, Imami, Ali S., McMullen, Megan R., Roychowdhury, Sanjoy, Nawabi, Atta M., Hipp, Jennifer A., Softic, Samir, Weinman, Steven A., McCullumsmith, Robert, Nagy, Laura E., Hinds, Terry D.

“…Background and Aims Resolution of pathways that converge to induce deleterious effects in hepatic diseases, such as in the later stages, have potential…”
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Complement and Alcoholic Liver Disease: Role of C1q in the Pathogenesis of Ethanol-Induced Liver Injury in Mice by Cohen, Jessica I, Roychowdhury, Sanjoy, McMullen, Megan R, Stavitsky, Abram B, Nagy, Laura E

“…Background & Aims Complement is involved in the development of alcoholic liver disease in mice; however, the mechanisms for complement activation during…”
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Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice by Bakhautdin, Bakytzhan, Das, Dola, Mandal, Palash, Roychowdhury, Sanjoy, Danner, Jazmine, Bush, Katelyn, Pollard, Katherine, Kaspar, James W, Li, Wei, Salomon, Robert G, McMullen, Megan R, Nagy, Laura E

“…Background & Aims Alcoholic liver disease is associated with inflammation and cell death. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with…”
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Complement Factor D protects mice from ethanol-induced inflammation and liver injury by McCullough, Rebecca L, McMullen, Megan R, Sheehan, Megan M, Poulsen, Kyle L, Roychowdhury, Sanjoy, Chiang, Dian J, Pritchard, Michele T, Caballeria, Juan, Nagy, Laura E

“…Complement plays a crucial role in microbial defense and clearance of apoptotic cells. Emerging evidence suggests complement is an important contributor to…”
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Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease by Singh, Shashi Shekhar, Kumar, Avinash, Welch, Nicole, Sekar, Jinendiran, Mishra, Saurabh, Bellar, Annette, Gangadhariah, Mahesha, Attaway, Amy, Al Khafaji, Hayder, Wu, Xiaoqin, Pathak, Vai, Agrawal, Vandana, McMullen, Megan R, Hornberger, Troy A, Nagy, Laura E, Davuluri, Gangarao, Dasarathy, Srinivasan

“…Signaling and metabolic perturbations contribute to dysregulated skeletal muscle protein homeostasis and secondary sarcopenia in response to a number of…”
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Macrophage migration inhibitory factor contributes to ethanol‐induced liver injury by mediating cell injury, steatohepatitis, and steatosis by Barnes, Mark A., McMullen, Megan R., Roychowdhury, Sanjoy, Pisano, Sorana G., Liu, Xiuli, Stavitsky, Abram B., Bucala, Richard, Nagy, Laura E.

“…Macrophage migration inhibitory factor (MIF), a multipotent protein that exhibits both cytokine and chemotactic properties, is expressed by many cell types,…”
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The anti‐inflammatory effects of adiponectin are mediated via a heme oxygenase‐1–dependent pathway in rat Kupffer cells by Mandal, Palash, Park, Pil‐Hoon, McMullen, Megan R., Pratt, Brian T., Nagy, Laura E.

“…Altered expression and activity of immunomodulatory cytokines plays a major role in the pathogenesis of alcoholic liver disease. Chronic ethanol feeding…”
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Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice by Poulsen, Kyle Lauren, McMullen, Megan R., Huang, Emily, Kibler, Christopher D., Sheehan, Megan M., Leng, Lin, Bucala, Richard, Nagy, Laura E.

“…Background Macrophage migration inhibitory factor (MIF), a pluripotent immune regulator, is an emerging mediator in alcohol‐related liver disease (ALD). MIF is…”
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Receptor-interacting protein 1 and 3 kinase activity are required for high-fat diet induced liver injury in mice by Wu, Xiaoqin, Arya, Rakesh K, Huang, Emily, McMullen, Megan R, Nagy, Laura E

“…The RIP1-RIP3-MLKL-mediated cell death pathway is associated with progression of non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). Previous work…”
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Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis by Chiang, Dian J, Roychowdhury, Sanjoy, Bush, Katelyn, McMullen, Megan R, Pisano, Sorana, Niese, Kathryn, Olman, Mitchell A, Pritchard, Michele T, Nagy, Laura E

“…The effect of moderate alcohol consumption on liver fibrosis is not well understood, but evidence suggests that adenosine may play a role in mediating the…”
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Membrane-bound O -acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury by Varadharajan, Venkateshwari, Ramachandiran, Iyappan, Massey, William J, Jain, Raghav, Banerjee, Rakhee, Horak, Anthony J, McMullen, Megan R, Huang, Emily, Bellar, Annette, Lorkowski, Shuhui W, Gulshan, Kailash, Helsley, Robert N, James, Isabella, Pathak, Vai, Dasarathy, Jaividhya, Welch, Nicole, Dasarathy, Srinivasan, Streem, David, Reizes, Ofer, Allende, Daniela S, Smith, Jonathan D, Simcox, Judith, Nagy, Laura E, Brown, J Mark

“…Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver…”
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Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome by McCullough, Rebecca L, McMullen, Megan R, Poulsen, Kyle L, Kim, Adam, Medof, M Edward, Nagy, Laura E

“…Chronic ethanol exposure results in inflammation in adipose tissue; this response is associated with activation of complement as well as the development of…”
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Functionally Diverse Inflammatory Responses in Peripheral and Liver Monocytes in Alcohol‐Associated Hepatitis by Kim, Adam, Bellar, Annette, McMullen, Megan R., Li, Xiaoxia, Nagy, Laura E.

“…Alcohol‐associated hepatitis (AH) is an acute inflammatory disease in which gut‐microbial byproducts enter circulation and peripheral immune cells infiltrate…”
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Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-α production by Thakur, Varsha, Pritchard, Michele T., McMullen, Megan R., Wang, Qifang, Nagy, Laura E.

“…Reactive oxygen species (ROS) contribute to the development of chronic ethanol‐induced liver injury. Although ROS modulate the activity of many signal…”
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