Search Results - "McMillan, Paul J."

The mass distribution and gravitational potential of the Milky Way by McMillan, Paul J

“…We present mass models of the Milky Way created to fit observational constraints and to be consistent with expectations from theoretical modelling. The method…”
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Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance by Yang, Tuo, Yeoh, Lee M., Tutor, Madel V., Dixon, Matthew W., McMillan, Paul J., Xie, Stanley C., Bridgford, Jessica L., Gillett, David L., Duffy, Michael F., Ralph, Stuart A., McConville, Malcolm J., Tilley, Leann, Cobbold, Simon A.

“…Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch13 (K13), although the precise…”
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Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis by O'Sullivan, Kim M, Lo, Camden Y, Summers, Shaun A, Elgass, Kirstin D, McMillan, Paul J, Longano, Anthony, Ford, Sharon L, Gan, Poh-Yi, Kerr, Peter G, Kitching, A Richard, Holdsworth, Stephen R

“…Myeloperoxidase (MPO) is an important neutrophil lysosomal enzyme, a major autoantigen, and a potential mediator of tissue injury in MPO-ANCA-associated…”
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The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly by Looker, Oliver, Blanch, Adam J, Liu, Boyin, Nunez-Iglesias, Juan, McMillan, Paul J, Tilley, Leann, Dixon, Matthew W A

“…Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein complex at the RBC surface. This…”
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The apical complex provides a regulated gateway for secretion of invasion factors in Toxoplasma by Katris, Nicholas J, van Dooren, Giel G, McMillan, Paul J, Hanssen, Eric, Tilley, Leann, Waller, Ross F

“…The apical complex is the definitive cell structure of phylum Apicomplexa, and is the focus of the events of host cell penetration and the establishment of…”
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Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response by Rawlinson, Stephen M., Zhao, Tianyue, Rozario, Ashley M., Rootes, Christina L., McMillan, Paul J., Purcell, Anthony W., Woon, Amanda, Marsh, Glenn A., Lieu, Kim G., Wang, Lin-Fa, Netter, Hans J., Bell, Toby D. M., Stewart, Cameron R., Moseley, Gregory W.

“…Recent studies indicate that nucleoli play critical roles in the DNA-damage response (DDR) via interaction of DDR machinery including NBS1 with nucleolar…”
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Mass models of the Milky Way by McMillan, Paul J.

“…We present a simple method for fitting parametrized mass models of the Milky Way to observational constraints. We take a Bayesian approach which allows us to…”
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Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage by Deligianni, Elena, Silmon de Monerri, Natalie C, McMillan, Paul J, Bertuccini, Lucia, Superti, Fabiana, Manola, Maria, Spanos, Lefteris, Louis, Christos, Blackman, Michael J, Tilley, Leann, Siden-Kiamos, Inga

“…Pore forming proteins such as those belonging to the membrane attack/perforin (MACPF) family have important functions in many organisms. Of the five MACPF…”
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A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite by Tran, Phuong N., Brown, Simon H. J., Mitchell, Todd W., Matuschewski, Kai, McMillan, Paul J., Kirk, Kiaran, Dixon, Matthew W. A., Maier, Alexander G.

“…ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human…”
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Cellular architecture of Plasmodium falciparum-infected erythrocytes by Hanssen, Eric, McMillan, Paul J., Tilley, Leann

“…Plasmodium falciparum is a protozoan parasite that is responsible for the most pathogenic form of human malaria. The particular virulence of this parasite…”
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Correction: Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage by Deligianni, Elena, Silmon de Monerri, Natalie C, McMillan, Paul J, Bertuccini, Lucia, Superti, Fabiana, Manola, Maria, Spanos, Lefteris, Louis, Christos, Blackman, Michael J, Tilley, Leann, Siden-Kiamos, Inga

“…[This corrects the article DOI: 10.1371/journal.pone.0201651.]…”
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A repeat sequence domain of the ring‐exported protein‐1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking by McHugh, Emma, Batinovic, Steven, Hanssen, Eric, McMillan, Paul J., Kenny, Shannon, Griffin, Michael D. W., Crawford, Simon, Trenholme, Katharine R., Gardiner, Donald L., Dixon, Matthew W. A., Tilley, Leann

“…Summary The malaria parasite Plasmodium falciparum dramatically remodels its host red blood cell to enhance its own survival, using a secretory membrane system…”
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Radial migration and vertical action in N-body simulations by Mikkola, Daniel, McMillan, Paul J, Hobbs, David

“…ABSTRACT We study the radial migration of stars as a function of orbital action as well as the structural properties of a large suite of N-body simulations of…”
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New stellar velocity substructures from Gaia DR3 proper motions by Mikkola, Daniel, McMillan, Paul J, Hobbs, David

“…ABSTRACT Local stellar motions are expected, and have been shown, to include signatures of the Galaxy’s past dynamical evolution. These are typically divided…”
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Plasmodium falciparum formins are essential for invasion and sexual stage development by Collier, Sophie, Pietsch, Emma, Dans, Madeline, Ling, Dawson, Tavella, Tatyana A., Lopaticki, Sash, Marapana, Danushka S., Shibu, Mohini A., Andrew, Dean, Tiash, Snigdha, McMillan, Paul J., Gilson, Paul, Tilley, Leann, Dixon, Matthew W. A.

“…The malaria parasite uses actin-based mechanisms throughout its lifecycle to control a range of biological processes including intracellular trafficking, gene…”
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Targeted mutagenesis of the ring-exported protein-1 of Plasmodium falciparum disrupts the architecture of Maurer's cleft organelles by Hanssen, Eric, Hawthorne, Paula, Dixon, Matthew W.A, Trenholme, Katharine R, McMillan, Paul J, Spielmann, Tobias, Gardiner, Donald L, Tilley, Leann

“…Mature red blood cells have no internal trafficking machinery, so the intraerythrocytic malaria parasite, Plasmodium falciparum, establishes its own transport…”
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Co-ordinated stage-dependent enhancement of Plasmodium falciparum antioxidant enzymes and heat shock protein expression in parasites growing in oxidatively stressed or G6PD-deficient red blood cells by Akide-Ndunge, Oscar Bate, Tambini, Elisa, Giribaldi, Giuliana, McMillan, Paul J, Müller, Sylke, Arese, Paolo, Turrini, Francesco

“…Plasmodium falciparum-parasitized red blood cells (RBCs) are equipped with protective antioxidant enzymes and heat shock proteins (HSPs). The latter are only…”
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Torus mapper: a code for dynamical models of galaxies by Binney, James, McMillan, Paul J.

“…We present a freely downloadable software package for modelling the dynamics of galaxies, which we call the Torus Mapper (tm). The package is based around…”
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The velocity distribution of white dwarfs in Gaia EDR3 by Mikkola, Daniel, McMillan, Paul J, Hobbs, David, Wimarsson, John

“…ABSTRACT Using a penalized maximum likelihood, we estimate, for the first time, the velocity distribution of white dwarfs in the solar neighbourhood. Our…”
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The uncertainty in Galactic parameters by McMillan, Paul J., Binney, James J.

“…We reanalyse the measurements of parallax, proper motion and line-of-sight velocity for 18 masers in high-mass star-forming regions presented by Reid et al. We…”
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