Search Results - "McManis, S"

Vibriobactin Antibodies: A Vaccine Strategy by Bergeron, Raymond J, Bharti, Neelam, Singh, Shailendra, McManis, James S, Wiegand, Jan, Green, Linda G

“…A new target strategy in the development of bacterial vaccines, the induction of antibodies to microbial outer membrane ferrisiderophore complexes, is…”
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The Design, Synthesis, and Evaluation of Organ-Specific Iron Chelators by Bergeron, Raymond J, Wiegand, Jan, McManis, James S, Bharti, Neelam

“…A series of iron chelators, three (S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid (DADFT) and three…”
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A Comparison of Structure−Activity Relationships between Spermidine and Spermine Analogue Antineoplastics by Bergeron, Raymond J, Feng, Yang, Weimar, William R, McManis, James S, Dimova, Hristina, Porter, Carl, Raisler, Brian, Phanstiel, Otto

“…A systematic investigation of the impact of spermidine analogues both in vitro and in vivo is described. The study characterizes the effects of these analogues…”
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Desferrithiocin: A Search for Clinically Effective Iron Chelators by Bergeron, Raymond J, Wiegand, Jan, McManis, James S, Bharti, Neelam

“…The successful search for orally active iron chelators to treat transfusional iron-overload diseases, e.g., thalassemia, is overviewed. The critical role of…”
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Antiproliferative Properties of Polyamine Analogs: A Structure-Activity Study by Bergeron, Raymond J, McManis, James S, Liu, Charles Z, Feng, Yang, Weimar, William R, Luchetta, Gabriel R, Wu, Qianhong, Ortiz-Ocasio, Jackqueline, Vinson, J. R. Timothy

“…A basis set of polyamine analogues was designed and synthesized. These compounds were used to initiate a systematic investigation of the role of chain length,…”
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Desazadesmethyldesferrithiocin Analogues as Orally Effective Iron Chelators by Bergeron, Raymond J, Wiegand, Jan, Weimar, William R, Vinson, J. R. Timothy, Bussenius, Jörg, Yao, Guo Wei, McManis, James S

“…Further structure−activity studies of desferrithiocin analogues are carried out. (S)-Desazadesmethyldesferrithiocin,…”
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Effects of C-4 Stereochemistry and C-4‘ Hydroxylation on the Iron Clearing Efficiency and Toxicity of Desferrithiocin Analogues by Bergeron, Raymond J, Wiegand, Jan, McManis, James S, McCosar, Bruce H, Weimar, William R, Brittenham, Gary M, Smith, Richard E

“…Additional structure−activity studies of desferrithiocin analogues are carried out. The effects of stereochemistry at C-4 on the ligands' iron clearing…”
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Total synthesis and structure revision of petrobactin by Bergeron, Raymond J, Huang, Guangfei, Smith, Richard E, Bharti, Neelam, McManis, James S, Butler, Alison

“…The total synthesis and the revised structural assignment of petrobactin, a siderophore isolated from the marine bacterium Marinobacter hydrocarbonoclasticus,…”
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Metabolically programmed iron chelators by Bergeron, Raymond J., Bharti, Neelam, McManis, James S., Wiegand, Jan

“…[Display omitted] Extensive structure activity relationship (SAR) studies focused on the desferrithiocin [DFT,…”
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Substituent Effects on Desferrithiocin and Desferrithiocin Analogue Iron-Clearing and Toxicity Profiles by Bergeron, Raymond J, Wiegand, Jan, Bharti, Neelam, McManis, James S

“…Desferrithiocin (DFT, 1) is a very efficient iron chelator when given orally. However, it is severely nephrotoxic. Structure–activity studies with 1…”
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(S)-4,5-Dihydro-2-(2-hydroxy-4-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic Acid Polyethers:  A Solution to Nephrotoxicity by Bergeron, Raymond J, Wiegand, Jan, McManis, James S, Vinson, John R. T, Yao, Hua, Bharti, Neelam, Rocca, James R

“…Previous studies revealed that within a family of ligands the more lipophilic chelators have better iron-clearing efficiency. The larger the log P app value of…”
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Polyamine-Vectored Iron Chelators:  The Role of Charge by Bergeron, Raymond J, Bharti, Neelam, Wiegand, Jan, McManis, James S, Yao, Hua, Prokai, Laszlo

“…The utility of polyamines as vectors for the intracellular transport of iron chelators is further described. Consistent with earlier results with polyamine…”
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The role of charge in polyamine analog recognition by Bergeron, Raymond J, McManis, James S, Weimar, William R, Schreier, Kathy, Gao, Fenglan, Wu, Qianhong, Ortiz-Ocasio, Jackqueline, Luchetta, Gabriel R, Porter, Carl, Vinson, J. R. Timothy

“…A series of analogues and homologues of N1,N12-diethylspermine (DESPM) was synthesized, and their biological properties were evaluated. These tetraamines…”
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Synthesis and Evaluation of Hydroxylated Polyamine Analogues as Antiproliferatives by Bergeron, Raymond J, Müller, Ralf, Huang, Guangfei, McManis, James S, Algee, Samuel E, Yao, Hua, Weimar, William R, Wiegand, Jan

“…A new means of accessing N -cyclopropylmethyl-N 11-ethylnorspermine (CPMENSPM) and the first synthesis of (2R,10S)-N 1-cyclopropylmethyl-2,10-dihydroxy-N…”
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Prevalence of psychiatric disorders in early stages of HIV infection by Brown, G R, Rundell, J R, McManis, S E, Kendall, S N, Zachary, R, Temoshok, L

“…As part of a military universal HIV screening program, 442 men were assessed for the presence of DSM-III-R defined psychiatric disorders and symptoms of…”
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Methoxylation of Desazadesferrithiocin Analogues:  Enhanced Iron Clearing Efficiency by Bergeron, Raymond J, Wiegand, Jan, McManis, James S, Bussenius, Jörg, Smith, Richard E, Weimar, William R

“…The impact of altering the octanol−water partition properties (log P) of analogues of desazadesferrithiocin,…”
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Polyamine Analogue Antidiarrheals:  A Structure−Activity Study by Bergeron, Raymond J, Wiegand, Jan, McManis, James S, Weimar, William R, Smith, Richard E, Algee, Samuel E, Fannin, Tammy L, Slusher, Michael A, Snyder, Patti S

“…The syntheses of a group of spermine polyamine analogues and their evaluation as antidiarrheals are described. Each compound was assessed in a rodent castor…”
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Synthesis and Evaluation of Hydroxylated Polyamine Analogues as Antiproliferatives by Bergeron, Raymond J, Müller, Ralf, Bussenius, Jörg, McManis, James S, Merriman, Ronald L, Smith, Richard E, Yao, Hua, Weimar, William R

“…The synthesis of four hydroxylated polyamine analogues, (2R,10R)-N ,N 11-diethyl-2,10-dihydroxynorspermine, (2S,10S)-N 1,N…”
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Partition-Variant Desferrithiocin Analogues:  Organ Targeting and Increased Iron Clearance by Bergeron, Raymond J, Wiegand, Jan, McManis, James S, Weimar, William R, Park, Jeong-Hyun, Eiler-McManis, Eileen, Bergeron, Jennifer, Brittenham, Gary M

“…Altering the lipophilicity (log P app) of desferrithiocin analogues can change the organ distribution of the chelators and lead to enhanced iron clearance. For…”
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Desferrithiocin analogue iron chelators: iron clearing efficiency, tissue distribution, and renal toxicity by Bergeron, Raymond J, Wiegand, Jan, Bharti, Neelam, McManis, James S, Singh, Shailendra

“…The current solution to iron-mediated damage in transfusional iron overload disorders is decorporation of excess unmanaged metal, chelation therapy. The…”
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