Search Results - "McManaman, J. L."

Functional regulation of xanthine oxidoreductase expression and localization in the mouse mammary gland: evidence of a role in lipid secretion by McManaman, J. L., Palmer, C. A., Wright, R. M., Neville, M. C.

“…Xanthine oxidoreductase (XOR), a key enzyme of purine metabolism, has been implicated in the secretion of the milk fat droplet in lactating mammary epithelial…”
Get full text

Cachectic effect of ciliary neurotrophic factor on innervated skeletal muscle by Martin, D, Merkel, E, Tucker, K K, McManaman, J L, Albert, D, Relton, J, Russell, D A

“…Recombinant human ciliary neurotrophic factor (rh-CNTF) was reported to attenuate skeletal muscle wasting in rats after unilateral transection of the sciatic…”
Get full text

Mouse Mammary Gland Xanthine Oxidoreductase: Purification, Characterization, and Regulation by McManaman, J.L., Neville, M.C., Wright, R.M.

“…Xanthine oxidoreductase (XOR) has been purified from lactating mouse mammary tissue and its properties and developmental expression have been characterized…”
Get full text

Lactogenic Hormones Regulate Xanthine Oxidoreductase and β-Casein Levels in Mammary Epithelial Cells by Distinct Mechanisms by McManaman, J.L., Hanson, L., Neville, M.C., Wright, R.M.

“…Xanthine oxidoreductase (XOR) is a prominent component of the milk lipid globule, whose concentration is selectively increased in mammary epithelial cells…”
Get full text

Biochemical Characterization of a Beta Cell Membrane Fraction Antigenic for Autoreactive T Cell Clones by Bergman, Barbara, McManaman, James L, Haskins, Kathryn

“…The two NOD-derived T cell clones, BDC-2.5 and BDC-6.9, are CD4+, Vβ4+, islet-specific, and diabetogenic. These two T cell clones show different response…”
Get full text

Peripheral nerve injury down-regulates CNTF expression in adult rat sciatic nerves by Rabinovsky, E D, Smith, G M, Browder, D P, Shine, H D, McManaman, J L

“…Ciliary neurotrophic factor (CNTF) is a 200-amino acid protein expressed in high concentrations by peripheral nerves and is thought to be important for the…”
Get more information

Reduction of Naturally Occurring Motoneuron Death in Vivo by a Target-Derived Neurotrophic Factor by Oppenheim, Ronald W., Haverkamp, Lanny J., Prevette, David, McManaman, James L., Appel, Stanley H.

“…Treatment of chick embryos in ovo with crude and partially purified extracts from embryonic hindlimbs (days 8 to 9) during the normal cell death period (days 5…”
Get full text

Purification of a skeletal muscle polypeptide which stimulates choline acetyltransferase activity in cultured spinal cord neurons by McManaman, J L, Crawford, F G, Stewart, S S, Appel, S H

“…Extracts of rat skeletal muscle contain neurotrophic factors which stimulate the development of choline acetyltransferase in embryonic day 14 rat spinal cord…”
Get full text

Temporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury by Smith, G M, Rabinovsky, E D, McManaman, J L, Shine, H D

“…Schwann cells in the intact sciatic nerve express high amounts of ciliary neurotrophic factor (CNTF), but 7 days after injury to the nerve expression…”
Get more information

Activation of the human aldehyde oxidase (hAOX1) promoter by tandem cooperative Sp1/Sp3 binding sites: identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter, distal activation sites, and a silencer element by Wright, R M, Riley, M G, Weigel, L K, Ginger, L A, Costantino, D A, McManaman, J L

“…Aldehyde oxidase (AOX) is a member of the molybdenum iron-sulfur flavoproteins and is of interest for its role in clinical drug metabolism and as a source of…”
Get more information

Characterization of nerve growth factor binding to embryonic rat spinal cord neurons by Marchetti, D, McManaman, J L

“…The binding of iodinated beta-nerve growth factor, [125I]-NGF, to embryonic (E16) rat spinal cord cells, was investigated to characterize the binding…”
Get more information

Regulation of tyrosine hydroxylase gene expression in IMR-32 neuroblastoma cells by basic fibroblast growth factor and ciliary neurotrophic factor by Rabinovsky, E D, Ramchatesingh, J, McManaman, J L

“…The actions of basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF) on tyrosine hydroxylase (TH) gene expression were studied using…”
Get more information

Alcohol-induced breast cancer: a proposed mechanism by Wright, Richard M., McManaman, James L., Repine, John E.

“…Alcohol consumption increases the risk for breast cancer in women by still undefined means. Alcohol metabolism is known to produce reactive oxygen species…”
Get full text

Regulation of putative muscle-derived neurotrophic factors by muscle activity and innervation: in vivo and in vitro studies by Houenou, LJ, McManaman, JL, Prevette, D, Oppenheim, RW

“…The normal embryonic development of spinal cord motoneurons (MNs) involves the proliferation of precursor cells followed by the degeneration of approximately…”
Get full text

Purification of Rat Liver Xanthine Oxidase and Xanthine Dehydrogenase by Affinity Chromatography on Benzamidine-Sepharose by McManaman, J.L., Shellman, V., Wright, R.M., Repine, J.E.

“…The oxidase form of xanthine dehydrogenase (XO; EC 1.1.3.22) has been purified approximately 200-fold from rat liver extracts using a three-step process of…”
Get full text

The N-terminal region of the human progesterone A-receptor. Structural analysis and the influence of the DNA binding domain by Bain, D L, Franden, M A, McManaman, J L, Takimoto, G S, Horwitz, K B

“…The role of the N-terminal region in nuclear receptor function was addressed by a biochemical and biophysical analysis of the progesterone receptor A-isoform…”
Get full text

The N-terminal region of human progesterone B-receptors: biophysical and biochemical comparison to A-receptors by Bain, D L, Franden, M A, McManaman, J L, Takimoto, G S, Horwitz, K B

“…To understand the basis for functional differences between the two human progesterone receptors (PR), we have carried out a detailed biochemical and…”
Get full text

Differential effects of neurotrophic factors on neurotransmitter development in the IMR-32 human neuroblastoma cell line by Rabinovsky, ED, Le, WD, McManaman, JL

“…The human neuroblastoma cell line IMR-32 exhibits both cholinergic and adrenergic properties. We have used IMR-32 cells to study the effects of CDF (CAT…”
Get full text

Transgenic mice expressing recombinant human protein C exhibit defects in lactation and impaired mammary gland development by PALMER, Carol A, LUBON, Henryk, MCMANAMAN, James L

“…To determine if the production of recombinant human protein C (rHPC) could be increased in milk, we created two lines of mice homozygous for the mouse whey…”
Get full text

Preparation and affinity purification of a novel, biologically active, CNTF fusion protein by Rabinovsky, E D, Browder, D P, McManaman, J L

“…A biologically active fusion protein comprising a short hydrophilic leader peptide fused to the N-terminus of rat CNTF was generated using commercially…”
Get more information