Search Results - "McMahon, Lori L"

Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model by Smith, Lindsey A., McMahon, Lori L.

“…Alzheimer's disease (AD) pathology begins decades prior to onset of clinical symptoms, and the entorhinal cortex and hippocampus are among the first and most…”
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Forskolin reverses the O-GlcNAcylation dependent decrease in GABAAR current amplitude at hippocampal synapses possibly at a neurosteroid site on GABAARs by Phillips, Shekinah, Chatham, John C., McMahon, Lori L.

“…GABAergic transmission is influenced by post-translational modifications, like phosphorylation, impacting channel conductance, allosteric modulator…”
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Estradiol-Induced Increase in the Magnitude of Long-Term Potentiation Is Prevented by Blocking NR2B-Containing Receptors by Smith, Caroline C, McMahon, Lori L

“…Estradiol, through activation of genomic estrogen receptors, induces changes in synaptic morphology and function in hippocampus, a brain region important for…”
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GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity by Besing, Rachel C., Rogers, Courtney O., Paul, Jodi R., Hablitz, Lauren M., Johnson, Russell L., McMahon, Lori L., Gamble, Karen L.

“…Hippocampal rhythms in clock gene expression, enzymatic activity, and long‐term potentiation (LTP) are thought to underlie day–night differences in memory…”
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Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats by Creed, Rose B., Roberts, Rosalinda C., Farmer, Charlene B., McMahon, Lori L., Goldberg, Matthew S.

“…Loss-of-function PTEN Induced Kinase 1 (PINK1) mutations cause early-onset familial Parkinson's disease (PD) with similar clinical and neuropathological…”
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Corrigendum to “Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model” [Neurobiology of Disease Volume 110, February 2018, Pages 166–179] by Smith, Lindsey A., McMahon, Lori L.

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Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3–CA1 synapses by Smith, Caroline C, Vedder, Lindsey C, McMahon, Lori L

“…Summary When circulating estrogen levels decline as a natural consequence of menopause and aging in women, there is an increased incidence of deficits in…”
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312 In vivo electrophysiology sex differences in the locus coeruleus of wild type F344 rats by Rae, Rosaria J., McMahon, Lori L.

“…OBJECTIVES/GOALS: Women are twice as susceptible to ailments like anxiety, PTSD, and Alzheimer’s disease compared to men. The locus coeruleus (LC), the primary…”
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Estradiol-induced increase in novel object recognition requires hippocampal NR2B-containing NMDA receptors by Vedder, Lindsey C., Smith, Caroline C., Flannigan, Alaina E., McMahon, Lori L.

“…17β‐estradiol (E2), at high circulating levels, enhances learning and memory in many women, making it a clinical treatment for hormone‐related cognitive…”
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Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice by Fusilier, Allison R., Davis, Jennifer A., Paul, Jodi R., Yates, Stefani D., McMeekin, Laura J., Goode, Lacy K., Mokashi, Mugdha V., Remiszewski, Natalie, van Groen, Thomas, Cowell, Rita M., McMahon, Lori L., Roberson, Erik D., Gamble, Karen L.

“…Patients with Alzheimer's disease (AD) often have fragmentation of sleep/wake cycles and disrupted 24-h (circadian) activity. Despite this, little work has…”
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Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability by Voskobiynyk, Yuliya, Roth, Jonathan R, Cochran, J Nicholas, Rush, Travis, Carullo, Nancy Vn, Mesina, Jacob S, Waqas, Mohammad, Vollmer, Rachael M, Day, Jeremy J, McMahon, Lori L, Roberson, Erik D

“…Genome-wide association studies identified the locus as a leading modulator of genetic risk in Alzheimer's disease (AD). One limitation in understanding 's…”
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Dentate Granule Cells Are Hyperexcitable in the TgF344-AD Rat Model of Alzheimer's Disease by Smith, Lindsey A, Goodman, Anthoni M, McMahon, Lori L

“…The dentate gyrus is both a critical gatekeeper for hippocampal signal processing and one of the first brain regions to become dysfunctional in Alzheimer's…”
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Estrogen-Induced Increase in the Magnitude of Long-Term Potentiation Occurs Only When the Ratio of NMDA Transmission to AMPA Transmission Is Increased by Smith, Caroline C, McMahon, Lori L

“…Elevated levels of estradiol enhance learning in mammals, including humans, likely a result of hormone-induced heightened plasticity at CA3-CA1 synapses. The…”
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Feasibility of cerium-doped LSO particles as a scintillator for x-ray induced optogenetics by Bartley, Aundrea F, Fischer, Máté, Bagley, Micah E, Barnes, Justin A, Burdette, Mary K, Cannon, Kelli E, Bolding, Mark S, Foulger, Stephen H, McMahon, Lori L, Weick, Jason P, Dobrunz, Lynn E

“…Non-invasive light delivery into the brain is needed for optogenetics to avoid physical damage. An innovative strategy could employ x-ray activation of…”
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Increased Excitability and Heightened Magnitude of Long-Term Potentiation at Hippocampal CA3-CA1 Synapses in a Mouse Model of Neonatal Hyperoxia Exposure by Ramani, Manimaran, Miller, Kiara, Ambalavanan, Namasivayam, McMahon, Lori L

“…Preterm infants exposed to supraphysiological oxygen (hyperoxia) during the neonatal period have hippocampal atrophy and cognitive dysfunction later in…”
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Duration of estrogen deprivation, not chronological age, prevents estrogen’s ability to enhance hippocampal synaptic physiology by Smith, Caroline C., Vedder, Lindsey C., Nelson, Amy R., Bredemann, Teruko M., McMahon, Lori L., McEwen, Bruce S.

“…Whether estrogen replacement is beneficial to cognitive health is controversial. Some studies have shown that estrogen replacement therapy (ERT) relieves…”
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Basal Synaptic Transmission and Long-Term Plasticity at CA3-CA1 Synapses Are Unaffected in Young Adult PINK1-Deficient Rats by Memon, Adeel A, Bagley, Micah E, Creed, Rose B, Amara, Amy W, Goldberg, Matthew S, McMahon, Lori L

“…Loss of function mutations in PARK6, the gene that encodes the protein PTEN-induced kinase 1 (PINK1), cause autosomal recessive familial Parkinson's disease…”
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Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment by Davis, Jennifer A., Paul, Jodi R., Yates, Stefani D., Cutts, Elam J., McMahon, Lori L., Pollock, Jennifer S., Pollock, David M., Bailey, Shannon M., Gamble, Karen L.

“…Feeding rodents a high-fat diet (HFD) disrupts normal behavioral rhythms, particularly meal timing. Within the brain, mistimed feeding shifts molecular rhythms…”
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Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy by Widman, Allie J., McMahon, Lori L.

“…Low-dose ketamine, an open-channel N-methyl D-aspartate receptor (NMDAR) antagonist, mediates rapid antidepressant effects in humans that are mimicked in…”
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Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation by Dyer-Reaves, Katie, Goodman, Anthoni M, Nelson, Amy R, McMahon, Lori L

“…Locus coeruleus (LC) provides the sole source of noradrenergic (NA) innervation to hippocampus, and it undergoes significant degeneration early in Alzheimer's…”
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