Search Results - "McMahon, Andrew P"

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte by Ohba, Shinsuke, He, Xinjun, Hojo, Hironori, McMahon, Andrew P.

“…Sox9 encodes an essential transcriptional regulator of chondrocyte specification and differentiation. When Sox9 nuclear activity was compared with markers of…”
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Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney by Ransick, Andrew, Lindström, Nils O., Liu, Jing, Zhu, Qin, Guo, Jin-Jin, Alvarado, Gregory F., Kim, Albert D., Black, Hannah G., Kim, Junhyong, McMahon, Andrew P.

“…Chronic kidney disease affects 10% of the population with notable differences in ethnic and sex-related susceptibility to kidney injury and disease. Kidney…”
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Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network by Dessaud, Eric, McMahon, Andrew P, Briscoe, James

“…Neuronal subtype specification in the vertebrate neural tube is one of the best-studied examples of embryonic pattern formation. Distinct neuronal subtypes are…”
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Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury by Gerhardt, Louisa M. S., Liu, Jing, Koppitch, Kari, Cippà, Pietro E., McMahon, Andrew P.

“…Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is associated with increased mortality and a heightened risk of chronic…”
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Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification by Hojo, Hironori, Ohba, Shinsuke, He, Xinjun, Lai, Lick Pui, McMahon, Andrew P.

“…In extant species, bone formation is restricted to vertebrate species. Sp7/Osterix is a key transcriptional determinant of bone-secreting osteoblasts. We…”
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Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors by Rodda, Stephen J, McMahon, Andrew P

“…Hedgehog and canonical Wnt/β-catenin signaling are implicated in development of the osteoblast, the bone matrix-secreting cell of the vertebrate skeleton. We…”
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The dynamics of methylammonium ions in hybrid organic–inorganic perovskite solar cells by Leguy, Aurelien M. A., Frost, Jarvist Moore, McMahon, Andrew P., Sakai, Victoria Garcia, Kockelmann, W., Law, ChunHung, Li, Xiaoe, Foglia, Fabrizia, Walsh, Aron, O’Regan, Brian C., Nelson, Jenny, Cabral, João T., Barnes, Piers R. F.

“…Methylammonium lead iodide perovskite can make high-efficiency solar cells, which also show an unexplained photocurrent hysteresis dependent on the…”
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Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney by Kumar, Sanjeev, Liu, Jing, Pang, Paul, Krautzberger, A. Michaela, Reginensi, Antoine, Akiyama, Haruhiko, Schedl, Andreas, Humphreys, Benjamin D., McMahon, Andrew P.

“…After acute kidney injury (AKI), surviving cells within the nephron proliferate and repair. We identify Sox9 as an acute epithelial stress response in renal…”
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A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation by Cippà, Pietro E., Liu, Jing, Sun, Bo, Kumar, Sanjeev, Naesens, Maarten, McMahon, Andrew P.

“…The mechanisms initiating late immune responses to an allograft are poorly understood. Here we show, via transcriptome analysis of serial protocol biopsies…”
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Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant by Kamberov, Yana G., Wang, Sijia, Tan, Jingze, Gerbault, Pascale, Wark, Abigail, Tan, Longzhi, Yang, Yajun, Li, Shilin, Tang, Kun, Chen, Hua, Powell, Adam, Itan, Yuval, Fuller, Dorian, Lohmueller, Jason, Mao, Junhao, Schachar, Asa, Paymer, Madeline, Hostetter, Elizabeth, Byrne, Elizabeth, Burnett, Melissa, McMahon, Andrew P., Thomas, Mark G., Lieberman, Daniel E., Jin, Li, Tabin, Clifford J., Morgan, Bruce A., Sabeti, Pardis C.

“…An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We…”
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Genome-wide RNA Tomography in the Zebrafish Embryo by Junker, Jan Philipp, Noël, Emily S., Guryev, Victor, Peterson, Kevin A., Shah, Gopi, Huisken, Jan, McMahon, Andrew P., Berezikov, Eugene, Bakkers, Jeroen, van Oudenaarden, Alexander

“…Advancing our understanding of embryonic development is heavily dependent on identification of novel pathways or regulators. Although genome-wide techniques…”
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Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning by Lindström, Nils O, Tran, Tracy, Guo, Jinjin, Rutledge, Elisabeth, Parvez, Riana K, Thornton, Matthew E, Grubbs, Brendan, McMahon, Jill A, McMahon, Andrew P

“…The nephron is the functional unit of the kidney, but the mechanism of nephron formation during human development is unclear. We conducted a detailed analysis…”
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Conserved and Divergent Features of Human and Mouse Kidney Organogenesis by Lindström, Nils O, McMahon, Jill A, Guo, Jinjin, Tran, Tracy, Guo, Qiuyu, Rutledge, Elisabeth, Parvez, Riana K, Saribekyan, Gohar, Schuler, Robert E, Liao, Christopher, Kim, Albert D, Abdelhalim, Ahmed, Ruffins, Seth W, Thornton, Matthew E, Baskin, Laurence, Grubbs, Brendan, Kesselman, Carl, McMahon, Andrew P

“…Human kidney function is underpinned by approximately 1,000,000 nephrons, although the number varies substantially, and low nephron number is linked to…”
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Lineage Tracing and Single-Nucleus Multiomics Reveal Novel Features of Adaptive and Maladaptive Repair after Acute Kidney Injury by Gerhardt, Louisa M S, Koppitch, Kari, van Gestel, Jordi, Guo, Jinjin, Cho, Sam, Wu, Haojia, Kirita, Yuhei, Humphreys, Benjamin D, McMahon, Andrew P

“…Understanding the mechanisms underlying adaptive and maladaptive renal repair after AKI and their long-term consequences is critical to kidney health. The…”
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Global Quantification of Tissue Dynamics in the Developing Mouse Kidney by Short, Kieran M., Combes, Alexander N., Lefevre, James, Ju, Adler L., Georgas, Kylie M., Lamberton, Timothy, Cairncross, Oliver, Rumballe, Bree A., McMahon, Andrew P., Hamilton, Nicholas A., Smyth, Ian M., Little, Melissa H.

“…Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of…”
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Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback by Menshykau, Denis, Michos, Odyssé, Lang, Christine, Conrad, Lisa, McMahon, Andrew P., Iber, Dagmar

“…Branching patterns and regulatory networks differ between branched organs. It has remained unclear whether a common regulatory mechanism exists and how…”
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Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature by Stenman, Jan M, Rajagopal, Jay, Carroll, Thomas J, Ishibashi, Makoto, McMahon, Jill, McMahon, Andrew P

“…Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly…”
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Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney by Lindström, Nils O, Guo, Jinjin, Kim, Albert D, Tran, Tracy, Guo, Qiuyu, De Sena Brandine, Guilherme, Ransick, Andrew, Parvez, Riana K, Thornton, Matthew E, Baskin, Laurence, Grubbs, Brendan, McMahon, Jill A, Smith, Andrew D, McMahon, Andrew P

“…Cellular interactions among nephron, interstitial, and collecting duct progenitors drive mammalian kidney development. In mice, Six2 nephron progenitor cells…”
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Six2 and Wnt Regulate Self-Renewal and Commitment of Nephron Progenitors through Shared Gene Regulatory Networks by Park, Joo-Seop, Ma, Wenxiu, O'Brien, Lori L., Chung, Eunah, Guo, Jin-Jin, Cheng, Jr-Gang, Valerius, M. Todd, McMahon, Jill A., Wong, Wing Hung, McMahon, Andrew P.

“…A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using…”
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Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis by Kobayashi, Akio, Mugford, Joshua W., Krautzberger, A. Michaela, Naiman, Natalie, Liao, Jessica, McMahon, Andrew P.

“…The mammalian kidney is a complex organ consisting of multiple cell types. We previously showed that the Six2-expressing cap mesenchyme is a multipotent…”
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