Search Results - "McLoughlin, Rachel M."

Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation by Kelly, Alanna M, Leech, John M, Doyle, Sarah L, McLoughlin, Rachel M

“…Staphylococcus aureus persistently colonises the anterior nares of a significant proportion of the healthy population, however the local immune response…”
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Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies by Clegg, Jonah, Soldaini, Elisabetta, McLoughlin, Rachel M, Rittenhouse, Stephen, Bagnoli, Fabio, Phogat, Sanjay

“…is one of the most important human pathogens worldwide. Its high antibiotic resistance profile reinforces the need for new interventions like vaccines in…”
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Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine by Ross, Pádraig J, Sutton, Caroline E, Higgins, Sarah, Allen, Aideen C, Walsh, Kevin, Misiak, Alicja, Lavelle, Ed C, McLoughlin, Rachel M, Mills, Kingston H G

“…Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One…”
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IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections by Leech, John M, Lacey, Keenan A, Mulcahy, Michelle E, Medina, Eva, McLoughlin, Rachel M

“…IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T…”
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The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease by Mannion, Jenny M., McLoughlin, Rachel M., Lalor, Stephen J.

“…The respiratory tract is home to a diverse microbial community whose influence on local and systemic immune responses is only beginning to be appreciated…”
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Bacterial toxins: Offensive, defensive, or something else altogether? by Rudkin, Justine K, McLoughlin, Rachel M, Preston, Andrew, Massey, Ruth C

“…The secretion of proteins that damage host tissue is well established as integral to the infectious processes of many bacterial pathogens. However, recent…”
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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4 by McNeela, Edel A, Burke, Aine, Neill, Daniel R, Baxter, Cathy, Fernandes, Vitor E, Ferreira, Daniela, Smeaton, Sarah, El-Rachkidy, Rana, McLoughlin, Rachel M, Mori, Andres, Moran, Barry, Fitzgerald, Katherine A, Tschopp, Jurg, Pétrilli, Virginie, Andrew, Peter W, Kadioglu, Aras, Lavelle, Ed C

“…Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells…”
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Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma by McLoughlin, Rachel M., PhD, Mills, Kingston H.G., PhD

“…The human intestine contains more than 100 trillion microorganisms that maintain a symbiotic relationship with the host. Under normal conditions, these…”
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Staphylococcus aureus and Influenza A Virus: Partners in Coinfection by Mulcahy, Michelle E, McLoughlin, Rachel M

“…Nasal carriage of Staphylococcus aureus is a significant risk factor for secondary staphylococcal pneumonia in influenza A virus (IAV)-infected hosts. However,…”
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Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design by Brown, Aisling F, Leech, John M, Rogers, Thomas R, McLoughlin, Rachel M

“…In apparent contrast to its invasive potential Staphylococcus aureus colonizes the anterior nares of 20-80% of the human population. The relationship between…”
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Making the Most of the Host; Targeting the Autophagy Pathway Facilitates Staphylococcus aureus Intracellular Survival in Neutrophils by Vozza, Emilio G., Mulcahy, Michelle E., McLoughlin, Rachel M.

“…The success of Staphylococcus aureus as a human commensal and an opportunistic pathogen relies on its ability to adapt to several niches within the host. The…”
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Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target by Lacey, Keenan A, Mulcahy, Michelle E, Towell, Aisling M, Geoghegan, Joan A, McLoughlin, Rachel M

“…Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune…”
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Target the Host, Kill the Bug; Targeting Host Respiratory Immunosuppressive Responses as a Novel Strategy to Improve Bacterial Clearance During Lung Infection by Kelly, Alanna M, McLoughlin, Rachel M

“…The lung is under constant pressure to protect the body from invading bacteria. An effective inflammatory immune response must be tightly orchestrated to…”
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IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3 by Fielding, Ceri A, McLoughlin, Rachel M, McLeod, Louise, Colmont, Chantal S, Najdovska, Meri, Grail, Dianne, Ernst, Matthias, Jones, Simon A, Topley, Nicholas, Jenkins, Brendan J

“…The successful resolution of inflammation is dependent upon the coordinated transition from the initial recruitment of neutrophils to a more sustained…”
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TRAM is required for TLR2 endosomal signaling to type I IFN induction by Stack, Julianne, Doyle, Sarah L, Connolly, Dympna J, Reinert, Line S, O'Keeffe, Kate M, McLoughlin, Rachel M, Paludan, Søren R, Bowie, Andrew G

“…Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively,…”
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Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin by Mulcahy, Michelle E, Geoghegan, Joan A, Monk, Ian R, O'Keeffe, Kate M, Walsh, Evelyn J, Foster, Timothy J, McLoughlin, Rachel M

“…Staphylococcus aureus asymptomatically colonises the anterior nares, but the host and bacterial factors that facilitate colonisation remain incompletely…”
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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon by Ryan, Tristram A. J., Hooftman, Alexander, Rehill, Aisling M., Johansen, Matt D., Brien, Eóin C. O’, Toller-Kawahisa, Juliana E., Wilk, Mieszko M., Day, Emily A., Weiss, Hauke J., Sarvari, Pourya, Vozza, Emilio G., Schramm, Fabian, Peace, Christian G., Zotta, Alessia, Miemczyk, Stefan, Nalkurthi, Christina, Hansbro, Nicole G., McManus, Gavin, O’Doherty, Laura, Gargan, Siobhan, Long, Aideen, Dunne, Jean, Cheallaigh, Clíona Ní, Conlon, Niall, Carty, Michael, Fallon, Padraic G., Mills, Kingston H. G., Creagh, Emma M., Donnell, James S. O’, Hertzog, Paul J., Hansbro, Philip M., McLoughlin, Rachel M., Wygrecka, Małgorzata, Preston, Roger J. S., Zasłona, Zbigniew, O’Neill, Luke A. J.

“…Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead…”
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The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma by Zasłona, Zbigniew, Case, Sarah, Early, James O, Lalor, Stephen J, McLoughlin, Rachel M, Curtis, Anne M, O'Neill, Luke A J

“…Our body clock drives rhythms in the expression of genes that have a 24-h periodicity. The transcription factor BMAL1 is a crucial component of the molecular…”
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Staphylococcal Protein A Induces Leukocyte Necrosis by Complexing with Human Immunoglobulins by Fox, Proinnsias G, Schiavetti, Francesca, Rappuoli, Rino, McLoughlin, Rachel M, Bagnoli, Fabio

“…One of the defining features of Staphylococcus aureus is its ability to evade and impair the human immune response through expression of staphylococcal protein…”
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Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival by Vozza, Emilio G, Daly, Clíodhna M, O'Rourke, Sinead A, Fitzgerald, Hannah K, Dunne, Aisling, McLoughlin, Rachel M

“…is one of the leading causes of antimicrobial-resistant infections whose success as a pathogen is facilitated by its massive array of immune evasion tactics,…”
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