Search Results - "McLoughlin, D M"

Bitemporal v. high-dose right unilateral electroconvulsive therapy for depression: a systematic review and meta-analysis of randomized controlled trials by Kolshus, E, Jelovac, A, McLoughlin, D M

“…Brief-pulse electroconvulsive therapy (ECT) is the most acutely effective treatment for severe depression though concerns persist about cognitive side-effects…”
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MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c by Gururajan, A, Naughton, M E, Scott, K A, O'Connor, R M, Moloney, G, Clarke, G, Dowling, J, Walsh, A, Ismail, F, Shorten, G, Scott, L, McLoughlin, D M, Cryan, J F, Dinan, T G

“…There is a growing emphasis in the field of psychiatry on the need to identify candidate biomarkers to aid in diagnosis and clinical management of depression,…”
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When less is more - microRNAs and psychiatric disorders by Kolshus, E., Dalton, V. S., Ryan, K. M., McLoughlin, D. M.

“…Objective MicroRNAs are small non‐coding RNA molecules that regulate gene expression, including genes involved in neuronal function and plasticity that have…”
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A randomized controlled trial with 4-month follow-up of adjunctive repetitive transcranial magnetic stimulation of the left prefrontal cortex for depression by Mogg, A, Pluck, G, Eranti, S V, Landau, S, Purvis, R, Brown, R G, Curtis, V, Howard, R, Philpot, M, McLoughlin, D M

“…Effectiveness of repetitive transcranial magnetic stimulation (rTMS) for major depression is unclear. The authors performed a randomized controlled trial…”
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From Molecules to Mind: Mechanisms of Action of Electroconvulsive Therapy by Ryan, K. M, McLoughlin, D. M

“…(Reprinted with permission from Acta Psychatrica Scandinavica (John Wiley & Sons, Ltd.); ©John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Acta…”
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Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology by Tudor, E.L, Galtrey, C.M, Perkinton, M.S, Lau, K.-F, De Vos, K.J, Mitchell, J.C, Ackerley, S, Hortobágyi, T, Vámos, E, Leigh, P.N, Klasen, C, McLoughlin, D.M, Shaw, C.E, Miller, C.C.J

“…Abstract Cytoplasmic ubiquitin-positive inclusions containing TAR-DNA-binding protein-43 (TDP-43) within motor neurons are the hallmark pathology of sporadic…”
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Vagus rules still apply by McLoughlin, D M

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Protein aggregates and dementia: is there a common toxicity? by Lovestone, S, McLoughlin, D M

“…This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in…”
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An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers by Tracy, D.K., O’Daly, O., Joyce, D.W., Michalopoulou, P.G., Basit, B.B., Dhillon, G., McLoughlin, D.M., Shergill, S.S.

“…Auditory verbal hallucinations (AVH) are the most prevalent symptom in schizophrenia. They are associated with increased activation within the temporoparietal…”
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ECT is evidence-based - a commentary on depression: why drugs and electricity are not the answer by Meechan, C F, Laws, K R, Young, A H, McLoughlin, D M, Jauhar, S

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From molecules to mind: mechanisms of action of electroconvulsive therapy by Ryan, K. M., McLoughlin, D. M.

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Peripheral blood microRNA and VEGFA mRNA changes following electroconvulsive therapy: implications for psychotic depression by Kolshus, E., Ryan, K. M., Blackshields, G., Smyth, P., Sheils, O., McLoughlin, D. M.

“…Objective MicroRNAs are short, non‐coding molecules that regulate gene expression. Here, we investigate the role of microRNAs in depression and…”
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A critique of narrative reviews of the evidence-base for ECT in depression by Meechan, C. F., Laws, K. R., Young, A. H., McLoughlin, D. M., Jauhar, S.

“…There has been recent debate regarding the efficacy of electroconvulsive therapy in the treatment of depression. This has been based on narrative reviews that…”
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Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: A comparison of ketamine and ECT by Allen, A.P, Naughton, M, Dowling, J, Walsh, A, Ismail, F, Shorten, G, Scott, L, McLoughlin, D.M, Cryan, J.F, Dinan, T.G, Clarke, G

“…Abstract Background Ketamine is associated with rapid antidepressant efficacy but the biological mechanisms underpinning this effect are unclear. Serum…”
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Kynurenine pathway metabolism and the neurobiology of treatment-resistant depression: Comparison of multiple ketamine infusions and electroconvulsive therapy by Allen, A.P., Naughton, M., Dowling, J., Walsh, A., O'Shea, R., Shorten, G., Scott, L., McLoughlin, D.M., Cryan, J.F., Clarke, G., Dinan, T.G.

“…Current first-line antidepressants can take weeks or months to decrease depressive symptoms. Low dose ketamine, an N-methyl-D-aspartate (NMDA) receptor…”
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Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder by Frodl, T, Carballedo, A, Hughes, M M, Saleh, K, Fagan, A, Skokauskas, N, McLoughlin, D M, Meaney, J, O'Keane, V, Connor, T J

“…Neuroplasticity may have a core role in the pathophysiology of major depressive disorder (MDD), a concept supported by experimental studies that found that…”
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Expression of the Fe65 adapter protein in adult and developing mouse brain by Kesavapany, S, Banner, S.J, Lau, K.-F, Shaw, C.E, Miller, C.C.J, Cooper, J.D, McLoughlin, D.M

“…Fe65 is a multimodular adaptor protein expressed mainly in the nervous system. Fe65 binds to the Alzheimer’s disease amyloid precursor protein (APP) and the…”
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Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo by Manser, C, Guillot, F, Vagnoni, A, Davies, J, Lau, K-F, McLoughlin, D M, De Vos, K J, Miller, C C J

“…A recent genome-wide association study identified the gene encoding lemur tyrosine kinase-2 ( LMTK2 ) as a susceptibility gene for prostate cancer. The…”
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Electroconvulsive therapy modulates plasma pigment epithelium-derived factor in depression: a proteomics study by Ryan, K M, Glaviano, A, O'Donovan, S M, Kolshus, E, Dunne, R, Kavanagh, A, Jelovac, A, Noone, M, Tucker, G M, Dunn, M J, McLoughlin, D M

“…Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, yet its mechanism of action is not fully understood. Peripheral blood…”
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Structural and functional changes in skeletal muscle in anorexia nervosa by MCLOUGHLIN, D. M, SPARGO, E, WASSIF, W. S, NEWHAM, D. J, PETERS, T. J, LANTOS, P. L, RUSSELL, G. F. M

“…Protein-energy malnutrition in anorexia nervosa is an under-recognised cause of muscle dysfunction. To characterise the skeletal myopathy that occurs in…”
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