Search Results - "McLeod, J F"

Synergistic effects of nateglinide and meal administration on insulin secretion in patients with type 2 diabetes mellitus by KEILSON, L, MATHER, S, WALTER, Y. H, SUBRAMANIAN, S, MCLEOD, J. F

“…This study assessed the synergistic effects of nateglinide (a non-sulfonylurea D-phenylalanine derivative) and meals on insulin secretion in 24 patients with…”
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Proof of Concept: A PhRMA Position Paper With Recommendations for Best Practice by Cartwright, M E, Cohen, S, Fleishaker, J C, Madani, S, McLeod, J F, Musser, B, Williams, S A

“…Proof of concept (POC) may be defined as the earliest point in the drug development process at which the weight of evidence suggests that it is “reasonably…”
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Improved control of mealtime glucose excursions with coadministration of nateglinide and metformin by Hirschberg, Y, Karara, A H, Pietri, A O, McLeod, J F

“…Improved control of mealtime glucose excursions with coadministration of nateglinide and metformin. Y Hirschberg , A H Karara , A O Pietri and J F McLeod…”
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GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers by McLeod, J.F., Leempoels, J.M., Peng, S.X., Dax, S.L., Myers, L.J., Golder, F.J.

“…Potassium-channels in the carotid body and the brainstem are important regulators of ventilation. The BKCa-channel contains response elements for CO, O2, and…”
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Pharmacokinetics, Pharmacodynamics, and Safety of Microencapsulated Octreotide Acetate in Healthy Subjects by Chen, Tianling, Miller, Thomas E, Prasad, Pratapa, Lee, James, Krauss, Jayashree, Miscik, Kristina, Kalafsky, Gaetana, McLeod, James E

“…The pharmacokinetics, pharmacodynamics, and safety of the marketed formulation of microencapsulated octreotide acetate were evaluated in an open‐label study in…”
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Effect of Meal Timing Not Critical for the Pharmacokinetics of Tegaserod (HTF 919) by Zhou, Honghui, Khalilieh, Sauzanne, Lau, Henry, Guerret, Madeleine, Osborne, Stuart, Alladina, Latifa, Laurent, Aziz L., McLeod, James F.

“…This study assessed the pharmacokinetic profiles of administering tegaserod (HTF 919) at different time intervals with respect to a meal. It was a randomized,…”
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The vitamin D-binding protein, α-fetoprotein, albumin multigene family: detection of transcripts in multiple tissues by McLeod, J F, Cooke, N E

“…The serum vitamin D-binding protein (DBP), a member of a multigene family that includes α-fetoprotein (αFP) and albumin (ALB), is expressed at high levels in…”
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Mealtime glucose regulation by nateglinide in type-2 diabetes mellitus by WALTER, Y. H, SPRATT, D. I, GARREFFA, S, MCLEOD, J. F

“…Pharmacodynamic effects of nateglinide, a novel antidiabetic agent, were investigated in patients with type-2 diabetes mellitus. Ten patients participated in…”
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Single-Dose Pharmacokinetics of Nateglinide in Subjects with Hepatic Cirrhosis by Choudhury, Somesh, Hirschberg, Yulia, Filipek, Ronald, Lasseter, Kenneth, McLeod, James F.

“…This single‐dose, open‐label, parallel‐group study compared the pharmacokinetics and tolerability of 120 mg doses of nateglinide, a physiologic mealtime…”
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Distribution of growth hormone receptor messenger ribonucleic acid containing and lacking exon 3 in human tissues by Mercado, M, DáVila, N, McLeod, J F, Baumann, G

“…The extent of expression of the GH receptor (GHR) in human tissues is largely unknown. In some cell lines and placenta, the GHR gene generates two different…”
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Familial neurohypophyseal diabetes insipidus associated with a signal peptide mutation by McLeod, J F, Kovács, L, Gaskill, M B, Rittig, S, Bradley, G S, Robertson, G L

“…We studied the pathophysiology, natural history, and genetic basis of familial neurohypophyseal diabetes insipidus (FNDI) in a caucasian kindred. Twelve…”
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The Effects of Tegaserod (HTF 919) on the Pharmacokinetics and Pharmacodynamics of Digoxin in Healthy Subjects by Zhou, Honghui, Ledford, Patricia C., Hubert, Martine, Appel-Dingemanse, Silke, Osborne, Stuart, McLeod, James F.

“…Tegaserod (HTF 919) is a highly specific 5‐HT4 receptor partial agonist that exhibits promotile activity throughout the gastrointestinal tract and is under…”
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"Cocktail" Approaches and Strategies in Drug Development: Valuable Tool or Flawed Science? by Zhou, Honghui, Tong, Zeen, McLeod, James F.

“…There is an increasing interest in the simultaneous administration of several probe substrates to characterize the activity of multiple drug‐metabolizing…”
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Vitamin D binding protein sequesters monomeric actin in the circulation of the rat by HARPER, K. D, MCLEOD, J. F, KOWALSKI, M. A, HADDAD, J. G

“…Plasma vitamin D binding protein (DBP) may scavenge actin released during cell lysis. We examined the plasma disappearance and tissue appearance of 125I-DBP,…”
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Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type 2 diabetes mellitus by KAHN, Steven E, MONTGOMERY, Brenda, HOWELL, William, LIGUEROS-SAYLAN, Monica, HSU, Chyi-Hung, DEVINENI, Damayanthi, MCLEOD, James F, HOROWITZ, Ann, FOLEY, James E

“…Insulin secretion is impaired in type 2 diabetes with the early response being essentially absent. The loss of this early insulin secretion is hypothesized to…”
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Interactions among Serum Vitamin D Binding Protein, Monomeric Actin, Profilin, and Profilactin by Mc Leod, J F, Kowalski, M A, Haddad, J G

“…Human serum vitamin D binding protein (hDBP), a 58-kDa inter-α-globulin, is known to bind, monomeric actin (G-actin) in equimolar quantities. Using monoclonal…”
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Mealtime glucose regulation with Nateglinide in healthy volunteers: comparison with repaglinide and placebo by KALBAG, Jyoti B, NEDELMAN, Jerry R, WALTER, Yulia H, MCLEOD, James F

“…This study was designed to compare the pharmacodynamic effects of single doses of nateglinide (A-4166), repaglinide, and placebo on mealtime insulin secretion…”
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Pharmacokinetics and Metabolism of Nateglinide in Humans by WEAVER, Margaret L, ORWIG, Barbara A, RODRIGUEZ, Lolita C, GRAHAM, Elizabeth D, CHIN, Jefferson A, SHAPIRO, Michael J, MCLEOD, James F, MANGOLD, James B

“…The pharmacokinetics and metabolism of nateglinide were studied in six healthy male subjects receiving a single oral (120 mg) and intravenous (60 mg) dose of […”
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Osteoporosis, cytokines, and glucocorticoids by McLeod, J F

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Characterization of a monoclonal antibody to human serum vitamin D binding protein (Gc globulin): recognition of an epitope hidden in membranes of circulating monocytes by McLeod, J F, Kowalski, M A, Haddad, J G

“…We have developed a murine hybridoma cell line that secretes a monoclonal antibody directed to the serum human vitamin D binding protein (hDBP), a…”
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