Search Results - "McLeod, D. Scott"

Relationship between RPE and Choriocapillaris in Age-Related Macular Degeneration by McLeod, D. Scott, Grebe, Rhonda, Bhutto, Imran, Merges, Carol, Baba, Takayuki, Lutty, Gerard A

“…The purpose of this study was to examine the relationships between choriocapillaris (CC) and retinal pigment epithelial changes in age-related macular…”
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Clinicopathologic Findings in Three Siblings With Geographic Atrophy by Edwards, Malia M, McLeod, D Scott, Shen, Mengxi, Grebe, Rhonda, Sunness, Janet S, Bhutto, Imran A, McDonnell, Erin, Pado, Alexandra M, Gregori, Giovanni, Rosenfeld, Philip J, Lutty, Gerard A

“…Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly worldwide. Clinical imaging and histopathologic studies are crucial to…”
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An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy by Bhutto, Imran A, Ogura, Shuntaro, Baldeosingh, Rajkumar, McLeod, D Scott, Lutty, Gerard A, Edwards, Malia M

“…Geographic atrophy (GA) is the late stage of non-neovascular age-related macular degeneration. A lack of animal models for GA has hampered treatment efforts…”
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Albumen Transport to Bruch's Membrane and RPE by Choriocapillaris Caveolae by Nakanishi, Masataka, Grebe, Rhonda, Bhutto, Imran A, Edwards, Malia, McLeod, D Scott, Lutty, Gerard A

“…The choriocapillaris (CC), the capillary network of the choroid, is positioned adjacent to Bruch's membrane (BM) and the RPE. The aim of this study was to…”
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Idiopathic preretinal glia in aging and age-related macular degeneration by Edwards, Malia M., McLeod, D. Scott, Bhutto, Imran A., Villalonga, Mercedes B., Seddon, Johanna M., Lutty, Gerard A.

“…During analysis of glia in wholemount aged human retinas, frequent projections onto the vitreal surface of the inner limiting membrane (ILM) were noted. The…”
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Effect of VEGF trap on normal retinal vascular development and oxygen-induced retinopathy in the dog by Lutty, Gerard A, McLeod, D Scott, Bhutto, Imran, Wiegand, Stanley J

“…Purpose. To evaluate the effects of a vascular endothelial growth factor trap (VEGF Trap) on retinal vascular development and pathologic neovascularization…”
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Histologic and Immunohistochemical Characterization of GA-Like Pathology in the Rat Subretinal Sodium Iodate Model by Naik, Poonam, Grebe, Rhonda, Bhutto, Imran A, McLeod, D Scott, Edwards, Malia M

“…Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration with multifactorial etiology and no well-established treatment. A model…”
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From blood islands to blood vessels: morphologic observations and expression of key molecules during hyaloid vascular system development by McLeod, D Scott, Hasegawa, Takuya, Baba, Takayuki, Grebe, Rhonda, Galtier d'Auriac, Ines, Merges, Carol, Edwards, Malia, Lutty, Gerard A

“…The mode of development of the human hyaloid vascular system (HVS) remains unclear. Early studies suggested that these blood vessels formed by vasculogenesis,…”
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Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye by Lutty, Gerard A., McLeod, D. Scott

“…The development of the ocular vasculatures is perfectly synchronized to provide the nutritional and oxygen requirements of the forming human eye. The fetal…”
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Maturation of the Fetal Human Choriocapillaris by Baba, Takayuki, Grebe, Rhonda, Hasegawa, Takuya, Bhutto, Imran, Merges, Carol, McLeod, D. Scott, Lutty, Gerard A

“…The purpose of this study was to examine the structural and functional maturation of the choriocapillaris (CC) and to determine when fenestrations form, the…”
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The initial fetal human retinal vasculature develops by vasculogenesis by McLeod, D. Scott, Hasegawa, Takuya, Prow, Tarl, Merges, Carol, Lutty, Gerard

“…There is increasing evidence that the hemangioblast, a common progenitor for hematopoietic cells and endothelial cells, participates in embryonic and…”
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Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy by Uno, Koichi, Prow, Tarl W., Bhutto, Imran A., Yerrapureddy, Adi, McLeod, D. Scott, Yamamoto, Masayuki, Reddy, Sekhar P., Lutty, Gerard A.

“…In the initial stage of retinopathy of prematurity (ROP), hyperoxia causes retinal blood vessel obliteration. This is thought to occur in part through…”
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Co-expression of endothelial and neuronal nitric oxide synthases in the developing vasculatures of the human fetal eye by McLeod, D. Scott, Baba, Takayuki, Bhutto, Imran A., Lutty, Gerard A.

“…Background Nitric oxide (NO) is a multifunctional gaseous molecule that regulates various physiological functions in both neuronal and non-neuronal cells. NO…”
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VEGF 165b in the developing vasculatures of the fetal human eye by Baba, Takayuki, McLeod, D. Scott, Edwards, Malia M., Merges, Carol, Sen, Tanusree, Sinha, Debasish, Lutty, Gerard A.

“…VEGF165b is an anti‐angiogenic form of VEGF165 produced by alternative splicing. The localization of pro‐angiogenic VEGF165 and anti‐angiogenic VEGF165b was…”
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Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas by KIM, Sahng Y, JOHNSON, Mary A, MCLEOD, D. Scott, ALEXANDER, Theresa, HANSEN, Barbara C, LUTTY, Gerard A

“…Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas Sahng Y. Kim 1 , Mary A. Johnson 2 , D. Scott McLeod 1 , Theresa…”
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Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration by Seddon, Johanna M, McLeod, D Scott, Bhutto, Imran A, Villalonga, Mercedes B, Silver, Rachel E, Wenick, Adam S, Edwards, Malia M, Lutty, Gerard A

“…Age-related macular degeneration (AMD) is a multifactorial disease with genetic and environmental factors contributing to risk. Histopathologic changes…”
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Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration by Kambhampati, Siva P., Bhutto, Imran A., Wu, Tony, Ho, Katie, McLeod, D. Scott, Lutty, Gerard A., Kannan, Rangaramanujam M.

“…Inflammation and neovascularization are key pathological events in human age-related macular degeneration (AMD). Activated microglia/macrophages (mi/ma) and…”
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Choriocapillaris dropout in early age-related macular degeneration by Lutty, Gerard A., McLeod, D. Scott, Bhutto, Imran A., Edwards, Malia M., Seddon, Johanna M.

“…Loss of choriocapillaris (CC) in advanced age-related macular degeneration (AMD) is well documented but changes in early AMD have not been quantified…”
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Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration by McLeod, D Scott, Bhutto, Imran, Edwards, Malia M, Silver, Rachel E, Seddon, Johanna M, Lutty, Gerard A

“…Increasing evidence suggests a role for macrophages in the pathogenesis of age-related macular degeneration (AMD). This study examined choroidal macrophages…”
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Evolution of oxidative stress, inflammation and neovascularization in the choroid and retina in a subretinal lipid induced age-related macular degeneration model by Kim, Soo-Young, Kambhampati, Siva P., Bhutto, Imran A., McLeod, D. Scott, Lutty, Gerard A., Kannan, Rangaramanujam M.

“…Oxidative stress, inflammation and neovascularization are the key pathological events that are implicated in human age-related macular degeneration (AMD)…”
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