Search Results - "McLennan, Susan"

Extracellular Vesicles: A New Frontier in Biomarker Discovery for Non-Alcoholic Fatty Liver Disease by Ban, Linda A, Shackel, Nicholas A, McLennan, Susan V

“…In recent years, the global burden of obesity and diabetes has seen a parallel rise in other metabolic complications, such as non-alcoholic fatty liver disease…”
Get full text

Skeletal muscle adiponectin induction in obesity and exercise by Martinez-Huenchullan, Sergio F., Tam, Charmaine S., Ban, Linda A., Ehrenfeld-Slater, Pamela, Mclennan, Susan V., Twigg, Stephen M.

“…Recent scientific efforts have focused on the detrimental effects that obesity has on the metabolic function of skeletal muscles and whether exercise can…”
Get full text

Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development by Tu, Thomas, Budzinska, Magdalena A, Maczurek, Annette E, Cheng, Robert, Di Bartolomeo, Anna, Warner, Fiona J, McCaughan, Geoffrey W, McLennan, Susan V, Shackel, Nicholas A

“…Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer that is derived from hepatocytes and is characterised by high mortality rate and poor…”
Get full text

Monocyte phenotype as a predictive marker for wound healing in diabetes-related foot ulcers by Min, Danqing, Nube, Vanessa, Tao, Anh, Yuan, Xin, Williams, Paul F., Brooks, Belinda A., Wong, Jencia, Twigg, Stephen M., McLennan, Susan V.

“…Delayed healing of diabetes-related foot ulcers (DRFUs) is associated with increased macrophage and matrix metalloproteinases (MMPs) at the wound site. Whether…”
Get full text

Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers by Liu, Yu, Min, Danqing, Bolton, Thyra, Nubé, Vanessa, Twigg, Stephen M, Yue, Dennis K, McLennan, Susan V

“…OBJECTIVE:--We studied the relationships of diabetic ulcer wound fluid matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and…”
Get full text

The Effect of a Sustained High-Fat Diet on the Metabolism of White and Brown Adipose Tissue and Its Impact on Insulin Resistance: A Selected Time Point Cross-Sectional Study by Maharjan, Babu Raja, McLennan, Susan V, Yee, Christine, Twigg, Stephen M, Williams, Paul F

“…(1) Background: studies on the long-term dynamic changes in fat depot metabolism in response to a high-fat diet (HFD) on hepatic lipid deposition and insulin…”
Get full text

Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes by Ren, Jing, Wang, Xiaoyu, Parry, Sarah N., Yee, Christine, Gorrell, Mark D., McLennan, Susan V., Twigg, Stephen M.

“…Type 2 diabetes is an independent risk factor for non-alcoholic steatohepatitis (NASH) progression and its mediators have not been resolved. In this study, a…”
Get full text

Sitagliptin Is More Effective Than Gliclazide in Preventing Pro-Fibrotic and Pro-Inflammatory Changes in a Rodent Model of Diet-Induced Non-Alcoholic Fatty Liver Disease by Ren, Jing, Wang, Xiaoyu, Yee, Christine, Gorrell, Mark D, McLennan, Susan V, Twigg, Stephen M

“…A diet-induced non-alcoholic fatty liver disease (NAFLD) model causing obesity in rodents was used to examine whether sitagliptin and gliclazide therapies have…”
Get full text

Deep Immune and RNA Profiling Revealed Distinct Circulating CD163+ Monocytes in Diabetes-Related Complications by Siwan, Elisha, Wong, Jencia, Brooks, Belinda A, Shinko, Diana, Baker, Callum J, Deshpande, Nandan, McLennan, Susan V, Twigg, Stephen M, Min, Danqing

“…CD163, a scavenger receptor with anti-inflammatory function expressed exclusively on monocytes/macrophages, is dysregulated in cases of diabetes complications…”
Get full text

Insulin treatment prevents wounding associated changes in tissue and circulating neutrophil MMP-9 and NGAL in diabetic rats by Abdollahi, Maryam, Ng, Taria Shin Yi, Rezaeizadeh, Alireza, Aamidor, Sarah, Twigg, Stephen M, Min, Danqing, McLennan, Susan V

“…Neutrophils are important for wound repair, but their persistence can impair the healing process. Neutrophils express matrix metalloproteinases including MMP-9…”
Get full text

Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis by Calabro, Sarah R, Maczurek, Annette E, Morgan, Alison J, Tu, Thomas, Wen, Victoria W, Yee, Christine, Mridha, Auvro, Lee, Maggie, d'Avigdor, William, Locarnini, Stephen A, McCaughan, Geoffrey W, Warner, Fiona J, McLennan, Susan V, Shackel, Nicholas A

“…The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of…”
Get full text

CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury by Yee, Christine, Main, Nathan M, Terry, Alexandra, Stevanovski, Igor, Maczurek, Annette, Morgan, Alison J, Calabro, Sarah, Potter, Alison J, Iemma, Tina L, Bowen, David G, Ahlenstiel, Golo, Warner, Fiona J, McCaughan, Geoffrey W, McLennan, Susan V, Shackel, Nicholas A

“…Chronic inflammation is the driver of liver injury and results in progressive fibrosis and eventual cirrhosis with consequences including both liver failure…”
Get full text

Constant-moderate versus high-intensity interval training on heart adiponectin levels in high-fat fed mice: a preventive and treatment approach by Martínez-Huenchullán, Sergio F., Fox, Sarah L., Tam, Charmaine S., Maharjan, Babu Raja, Olaya-Agudo, Luisa F., Ehrenfeld, Pamela, Williams, Paul F., Mclennan, Susan V., Twigg, Stephen M.

“…Research has described that adiponectin plays a key role in cardiomyocytes metabolism, however, the effects of exercise during obesity on cardiac adiponectin…”
Get full text

Exercise induces favorable metabolic changes in white adipose tissue preventing high‐fat diet obesity by Maharjan, Babu R., Martinez‐Huenchullan, Sergio F., Mclennan, Susan V., Twigg, Stephen M., Williams, Paul F.

“…Diet and/or exercise are cost effective interventions to treat obesity. However, it is unclear if the type of exercise undertaken can prevent the onset of…”
Get full text

Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis by Lo, Lisa, McLennan, Susan V, Williams, Paul F, Bonner, James, Chowdhury, Sumaiya, McCaughan, Geoffrey W, Gorrell, Mark D, Yue, Dennis K, Twigg, Stephen M

“…Background & Aims While type 2 diabetes is an independent risk factor for worsening of human non-alcoholic steatohepatitis (NASH) in clinical studies, it has…”
Get full text

Constant-Moderate and High-Intensity Interval Training Have Differential Benefits on Insulin Sensitive Tissues in High-Fat Fed Mice by Martinez-Huenchullan, Sergio F, Ban, Linda A, Olaya-Agudo, Luisa F, Maharjan, Babu Raja, Williams, Paul F, Tam, Charmaine S, Mclennan, Susan V, Twigg, Stephen M

“…In a mouse model of diet-induced obesity, this study determined if two exercise prescriptions with equivalent time and distance covered, [constant-moderate…”
Get full text

The Effect of TGFβ1 in Adipocyte on Inflammatory and Fibrotic Markers at Different Stages of Adipocyte Differentiation by Maharjan, Babu Raja, McLennan, Susan V, Twigg, Stephen M, Williams, Paul F

“…Transforming growth factor beta (TGFβ) is a versatile cytokine. Although a profibrotic role of TGFβ is well established, its effect on tissue inhibitor of…”
Get full text

Hepatocytes in liver injury: Victim, bystander, or accomplice in progressive fibrosis? by Tu, Thomas, Calabro, Sarah R., Lee, Aimei, Maczurek, Annette E., Budzinska, Magdalena A., Warner, Fiona J., McLennan, Susan V., Shackel, Nicholas A.

“…Chronic liver disease causes significant morbidity and mortality through progressive fibrosis, cirrhosis, and liver cancer. The classical theory of…”
Get full text

Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype by Farrell, Geoffrey C., Mridha, Auvro R., Yeh, Matthew M., Arsov, Todor, Van Rooyen, Derrick M., Brooling, John, Nguyen, Tori, Heydet, Deborah, Delghingaro-Augusto, Viviane, Nolan, Christopher J., Shackel, Nicholas A., McLennan, Susan V., Teoh, Narci C., Larter, Claire Z.

“…Background & Aims Obese Alms1 mutant (foz/foz) NOD.B10 mice develop diabetes and fibrotic NASH when fed high‐fat(HF) diet. To establish whether diabetes or…”
Get full text

Topical application of the bee hive protectant propolis is well tolerated and improves human diabetic foot ulcer healing in a prospective feasibility study by Henshaw, Frances R, Bolton, Thyra, Nube, Vanessa, Hood, Anita, Veldhoen, Danielle, Pfrunder, Louise, McKew, Genevieve L, Macleod, Colin, McLennan, Susan V, Twigg, Stephen M

“…Abstract Aims Propolis is a naturally occurring anti-inflammatory bee derived protectant resin. We have previously reported that topically applied propolis…”
Get full text