Search Results - "McLean, Will J"

Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells by McLean, Will J., Yin, Xiaolei, Lu, Lin, Lenz, Danielle R., McLean, Dalton, Langer, Robert, Karp, Jeffrey M., Edge, Albert S.B.

“…Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to…”
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Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs by McLean, Will J, McLean, Dalton T, Eatock, Ruth Anne, Edge, Albert S B

“…Disorders of hearing and balance are most commonly associated with damage to cochlear and vestibular hair cells or neurons. Although these cells are not…”
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BK channels mediate cholinergic inhibition of high frequency cochlear hair cells by Wersinger, Eric, McLean, Will J, Fuchs, Paul A, Pyott, Sonja J

“…Outer hair cells are the specialized sensory cells that empower the mammalian hearing organ, the cochlea, with its remarkable sensitivity and frequency…”
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Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study by McLean, Will J., Hinton, Ashley S., Herby, Jenna T.J., Salt, Alec N., Hartsock, Jared J., Wilson, Sam, Lucchino, David L., Lenarz, Thomas, Warnecke, Athanasia, Prenzler, Nils, Schmitt, Heike, King, Susan, Jackson, Lance E., Rosenbloom, Jeffrey, Atiee, George, Bear, Moraye, Runge, Christina L., Gifford, René H., Rauch, Steven D., Lee, Daniel J., Langer, Robert, Karp, Jeffrey M., Loose, Christopher, LeBel, Carl

“…There are no approved pharmacologic therapies for chronic sensorineural hearing loss (SNHL). The combination of CHIR99021+valproic acid (CV, FX-322) has been…”
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Approaches to Treat Sensorineural Hearing Loss by Hair-Cell Regeneration: The Current State of Therapeutic Developments and Their Potential Impact on Audiological Clinical Practice by Hinton, Ashley S, Yang-Hood, Aizhen, Schrader, Angela D, Loose, Christopher, Ohlemiller, Kevin K, McLean, Will J

“…Sensorineural hearing loss (SNHL) is typically a permanent and often progressive condition that is commonly attributed to sensory cell loss. All vertebrates…”
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Distribution of Na,K-ATPase α Subunits in Rat Vestibular Sensory Epithelia by Schuth, Olga, McLean, Will J., Eatock, Ruth Anne, Pyott, Sonja J.

“…ABSTRACT The afferent encoding of vestibular stimuli depends on molecular mechanisms that regulate membrane potential, concentration gradients, and ion and…”
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Distribution of the Na,K-ATPase α Subunit in the Rat Spiral Ganglion and Organ of Corti by McLean, Will J., Smith, K. Anne, Glowatzki, Elisabeth, Pyott, Sonja J.

“…Processing of sound in the cochlea involves both afferent and efferent innervation. The Na,K-ATPase (NKA) is essential for cells that maintain hyperpolarized…”
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Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study by McLean, Will J., Hinton, Ashley S., Herby, Jenna T.J., Salt, Alec N., Hartsock, Jared J., Wilson, Sam, Lucchino, David L., Lenarz, Thomas, Warnecke, Athanasia, Prenzler, Nils, Schmitt, Heike, King, Susan, Jackson, Lance E., Rosenbloom, Jeffrey, Atiee, George, Bear, Moraye, Runge, Christina L., Gifford, René H., Rauch, Steven D., Lee, Daniel J., Langer, Robert, Karp, Jeffrey M., Loose, Christopher, LeBel, Carl

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Distribution of Na,K-ATPase [alpha] Subunits in Rat Vestibular Sensory Epithelia by Schuth, Olga, Mclean, Will J, Eatock, Ruth Anne, Pyott, Sonja J

“…The afferent encoding of vestibular stimuli depends on molecular mechanisms that regulate membrane potential, concentration gradients, and ion and…”
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Distribution of the Na,K-ATPase [alpha] Subunit in the Rat Spiral Ganglion and Organ of Corti by Mclean, Will J, Smith, K Anne, Glowatzki, Elisabeth, Pyott, Sonja J

“…Processing of sound in the cochlea involves both afferent and efferent innervation. The Na,K-ATPase (NKA) is essential for cells that maintain hyperpolarized…”
Get full text