Search Results - "McLean, Pamela"

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies by Mazzulli, Joseph R., Xu, You-Hai, Sun, Ying, Knight, Adam L., McLean, Pamela J., Caldwell, Guy A., Sidransky, Ellen, Grabowski, Gregory A., Krainc, Dimitri

“…Parkinson's disease (PD), an adult neurodegenerative disorder, has been clinically linked to the lysosomal storage disorder Gaucher disease (GD), but the…”
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α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling by Wang, Lina, Das, Utpal, Scott, David A., Tang, Yong, McLean, Pamela J., Roy, Subhojit

“…The normal functions and pathologic facets of the small presynaptic protein α-synuclein (α-syn) are of exceptional interest. In previous studies, we found that…”
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Exosomal cell-to-cell transmission of alpha synuclein oligomers by Danzer, Karin M, Kranich, Lisa R, Ruf, Wolfgang P, Cagsal-Getkin, Ozge, Winslow, Ashley R, Zhu, Liya, Vanderburg, Charles R, McLean, Pamela J

“…Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of sporadic and familial Parkinson's disease (PD) as well as dementia with Lewy…”
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Protein degradation pathways in Parkinson’s disease: curse or blessing by Ebrahimi-Fakhari, Darius, Wahlster, Lara, McLean, Pamela J.

“…Protein misfolding, aggregation and deposition are common disease mechanisms in many neurodegenerative diseases including Parkinson’s disease (PD)…”
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Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease by Grozdanov, Veselin, Bousset, Luc, Hoffmeister, Meike, Bliederhaeuser, Corinna, Meier, Christoph, Madiona, Karine, Pieri, Laura, Kiechle, Martin, McLean, Pamela J., Kassubek, Jan, Behrends, Christian, Ludolph, Albert C., Weishaupt, Jochen H., Melki, Ronald, Danzer, Karin M.

“…Objective Excessive inflammation in the central nervous system (CNS) and the periphery can result in neurodegeneration and parkinsonism. Recent evidence…”
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Cellular models of alpha‐synuclein toxicity and aggregation by Delenclos, Marion, Burgess, Jeremy D., Lamprokostopoulou, Agaristi, Outeiro, Tiago F., Vekrellis, Kostas, McLean, Pamela J.

“…Misfolding and aggregation of alpha‐synuclein (α‐synuclein) with concomitant cytotoxicity is a hallmark of Lewy body related disorders such as Parkinson’s…”
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Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway by Park, Jae-Hyeon, Burgess, Jeremy D, Faroqi, Ayman H, DeMeo, Natasha N, Fiesel, Fabienne C, Springer, Wolfdieter, Delenclos, Marion, McLean, Pamela J

“…Misfolding and aggregation of the presynaptic protein alpha-synuclein (αsyn) is a hallmark of Parkinson's disease (PD) and related synucleinopathies. Although…”
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SIRT1 protects against α-synuclein aggregation by activating molecular chaperones by Donmez, Gizem, Arun, Anirudh, Chung, Chee-Yeun, McLean, Pamela J, Lindquist, Susan, Guarente, Leonard

“…α-Synuclein is a key molecule in the pathogenesis of synucleinopathy including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy…”
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Biomarkers in Parkinson's disease: Advances and strategies by Delenclos, Marion, Jones, Daryl R, McLean, Pamela J, Uitti, Ryan J

“…Abstract Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive motor disturbances and affects more than 1% of the worldwide…”
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Formation of toxic oligomeric alpha-synuclein species in living cells by Outeiro, Tiago Fleming, Putcha, Preeti, Tetzlaff, Julie E, Spoelgen, Robert, Koker, Mirjam, Carvalho, Filipe, Hyman, Bradley T, McLean, Pamela J

“…Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD)…”
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α-Synuclein oligomers and clinical implications for Parkinson disease by Kalia, Lorraine V., Kalia, Suneil K., McLean, Pamela J., Lozano, Andres M., Lang, Anthony E.

“…Protein aggregation within the central nervous system has been recognized as a defining feature of neurodegenerative diseases since the early 20th century…”
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Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates by Jiang, Peizhou, Gan, Ming, Yen, Shu-Hui, McLean, Pamela J., Dickson, Dennis W.

“…In neurodegenerative diseases, seeding is a process initiated by the internalization of exogenous protein aggregates. Multiple pathways for internalization of…”
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Chaperones in Neurodegeneration by Lindberg, Iris, Shorter, James, Wiseman, R Luke, Chiti, Fabrizio, Dickey, Chad A, McLean, Pamela J

“…Cellular protein homeostasis (proteostasis) maintains the integrity of the proteome and includes protein synthesis, folding, oligomerization, and turnover;…”
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Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein by Ebrahimi-Fakhari, Darius, Cantuti-Castelvetri, Ippolita, Fan, Zhanyun, Rockenstein, Edward, Masliah, Eliezer, Hyman, Bradley T, McLean, Pamela J, Unni, Vivek K

“…Increased intracellular levels of α-synuclein are implicated in Parkinson's disease and related disorders and may be caused by alterations in the…”
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Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease by Theodore, Shaji, Cao, Shuwen, McLean, Pamela J, Standaert, David G

“…Microglial activation and adaptive immunity have been implicated in the neurodegenerative processes in Parkinson disease. It has been proposed that these…”
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Optimizing SH-SY5Y cell culture: exploring the beneficial effects of an alternative media supplement on cell proliferation and viability by Kaya, Zeynep Bengisu, Santiago-Padilla, Valeria, Lim, Melina, Boschen, Suelen L., Atilla, Pergin, McLean, Pamela J.

“…In the quest to unravel the mysteries of neurological diseases, comprehending the underlying mechanisms is supreme. The SH-SY5Y human neuroblastoma cell line…”
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Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5) by Kalia, Lorraine V, Kalia, Suneil K, Chau, Hien, Lozano, Andres M, Hyman, Bradley T, McLean, Pamela J

“…Parkinson's disease (PD) is a common neurodegenerative condition in which abnormalities in protein homeostasis, or proteostasis, may lead to accumulation of…”
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CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage by Sun, Jichao, Carlson-Stevermer, Jared, Das, Utpal, Shen, Minjie, Delenclos, Marion, Snead, Amanda M., Koo, So Yeon, Wang, Lina, Qiao, Dianhua, Loi, Jonathan, Petersen, Andrew J., Stockton, Michael, Bhattacharyya, Anita, Jones, Mathew V., Zhao, Xinyu, McLean, Pamela J., Sproul, Andrew A., Saha, Krishanu, Roy, Subhojit

“…CRISPR/Cas9 guided gene-editing is a potential therapeutic tool, however application to neurodegenerative disease models has been limited. Moreover,…”
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Alpha-synuclein and tau: teammates in neurodegeneration? by Moussaud, Simon, Jones, Daryl R, Moussaud-Lamodière, Elisabeth L, Delenclos, Marion, Ross, Owen A, McLean, Pamela J

“…The accumulation of α-synuclein aggregates is the hallmark of Parkinson's disease, and more generally of synucleinopathies. The accumulation of tau aggregates…”
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Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson's disease by Bhattarai, Yogesh, Si, Jie, Pu, Meng, Ross, Owen A, McLean, Pamela J, Till, Lisa, Moor, William, Grover, Madhusudan, Kandimalla, Karunya K, Margolis, Kara G, Farrugia, Gianrico, Kashyap, Purna C

“…Parkinson's disease (PD) is a common neurodegenerative disorder characterized primarily by motor and non-motor gastrointestinal (GI) deficits. GI symptoms'…”
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