Search Results - "McLean, P J"

Molecular chaperones as rational drug targets for Parkinson's disease therapeutics by Kalia, S K, Kalia, L V, McLean, P J

“…Parkinson's disease is a neurodegenerative movement disorder that is caused, in part, by the loss of dopaminergic neurons within the substantia nigra pars…”
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α-Synuclein–enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons by McLean, P.J, Kawamata, H, Hyman, B.T

“…α-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, and mutations in α-synuclein are associated…”
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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice by Yue, M, Hinkle, K.M, Davies, P, Trushina, E, Fiesel, F.C, Christenson, T.A, Schroeder, A.S, Zhang, L, Bowles, E, Behrouz, B, Lincoln, S.J, Beevers, J.E, Milnerwood, A.J, Kurti, A, McLean, P.J, Fryer, J.D, Springer, W, Dickson, D.W, Farrer, M.J, Melrose, H.L

“…Abstract Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson's disease. The physiological and pathological roles of…”
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Hsp70 Reduces α-Synuclein Aggregation and Toxicity by Klucken, Jochen, Shin, Youngah, Masliah, Eliezer, Hyman, Bradley T., McLean, Pamela J.

“…Aggregation and cytotoxicity of misfolded α-synuclein is postulated to be crucial in the disease process of neurodegenerative disorders such as Parkinson's…”
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Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies by Klucken, J, McLean, P J, Gomez-Tortosa, E, Ingelsson, M, Hyman, Bradley T

“…Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders that share progressive dementia as the common major clinical…”
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DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients by Lorenzo-Betancor, O., Ogaki, K., Soto-Ortolaza, A. I., Labbe, C., Walton, R. L., Strongosky, A. J., van Gerpen, J. A., Uitti, R. J., McLean, P. J., Springer, W., Siuda, J., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., McCarthy, A., Lynch, T., Puschmann, A., Rektorova, I., Sanotsky, Y., Vilariño-Güell, C., Farrer, M. J., Ferman, T. J., Boeve, B. F., Petersen, R. C., Parisi, J. E., Graff-Radford, N. R., Dickson, D. W., Wszolek, Z. K., Ross, O. A.

“…Background Recently, a novel mutation in exon 24 of DNAJC13 gene (p.Asn855Ser, rs387907571) has been reported to cause autosomal dominant Parkinson's disease…”
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TorsinA and heat shock proteins act as molecular chaperones: suppression of α‐synuclein aggregation by McLean, Pamela J., Kawamata, Hibiki, Shariff, Saadat, Hewett, Jeffrey, Sharma, Nutan, Ueda, Kenji, Breakefield, Xandra O., Hyman, Bradley T.

“…TorsinA, a protein with homology to yeast heat shock protein104, has previously been demonstrated to colocalize with α‐synuclein in Lewy bodies, the…”
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Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies by SHARMA, Nutan, MCLEAN, Pamela J, KAWAMATA, Hibiki, IRIZARRY, Michael C, HYMAN, Bradley T

“…Alpha-synuclein, a protein in which two mutations have been identified that cause autosomal dominant Parkinson's disease, is thought to serve as a nidus for…”
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Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations by McLean, P J, Kawamata, H, Ribich, S, Hyman, B T

“…Two missense mutations (Ala-30 --> Pro and Ala-53 --> Thr) in the gene encoding alpha-synuclein are associated with rare autosomal dominant forms of familial…”
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Subcellular localization of alpha-synuclein in primary neuronal cultures: effect of missense mutations by McLean, P J, Ribich, S, Hyman, B T

“…Numerous recent observations have implicated alpha-synuclein in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease,…”
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A close association of torsinA and α-synuclein in Lewy bodies a fluorescence resonance energy transfer study by SHARMA, Nutan, HEWETT, Jeffrey, OZELIUS, Laurie J, RAMESH, Vijaya, MCLEAN, Pamela J, BREAKEFIELD, Xandra O, HYMAN, Bradley T

“…TorsinA, a novel protein in which a mutation causes dominant, early onset torsion dystonia, may serve as a chaperone for misfolded proteins that require…”
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Alpha-Synuclein and Chaperones in Dementia With Lewy Bodies by Cantuti-Castelvetri, Ippolita, Klucken, Jochen, Ingelsson, Martin, Ramasamy, Karunya, McLean, Pamela J, Frosch, Matthew P, Hyman, Bradley T, Standaert, David G

“…The protein alpha-synuclein (ASYN) is thought to be involved in the development of dementia with Lewy bodies (DLB). Overexpression of ASYN has been linked to…”
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A single amino acid substitution differentiates Hsp70-dependent effects on α-synuclein degradation and toxicity by Klucken, Jochen, Shin, Youngah, Hyman, Bradley T., McLean, Pamela J.

“…α-Synuclein aggregation and toxicity play a major role in Parkinson's disease and dementia with Lewy bodies. Hsp70 is a multipurpose stress response chaperone…”
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Interaction of α‐synuclein and synphilin‐1: effect of Parkinson's disease‐associated mutations by Kawamata, Hibiki, McLean, Pamela J., Sharma, Nutan, Hyman, Bradley T.

“…α‐Synuclein is a major component of Lewy bodies, a neuropathological feature of Parkinson's disease. Two α‐synuclein mutations, Ala53Thr and Ala30Pro, are…”
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Contingent attentional capture or delayed allocation of attention? by Remington, R W, Folk, C L, McLean, J P

“…Under certain circumstances, external stimuli will elicit an involuntary shift of spatial attention, referred to as attentional capture. According to the…”
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Small heat shock proteins protect against α-synuclein-induced toxicity and aggregation by Outeiro, Tiago Fleming, Klucken, Jochen, Strathearn, Katherine E., Liu, Fang, Nguyen, Paul, Rochet, Jean-Christophe, Hyman, Bradley T., McLean, Pamela J.

“…Protein misfolding and inclusion formation are common events in neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD) or…”
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Adrenocortical carcinoma and hypoglycemia: evidence for production of nonsuppressible insulin-like activity by the tumor by Hyodo, T, Megyesi, K, Kahn, C R, McLean, J P, Friesen, H G

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Detection of novel intracellular α-synuclein oligomeric species by fluorescence lifetime imaging by Klucken, Jochen, Outeiro, Tiago F, Nguyen, Paul, McLean, Pamela J, Hyman, Bradley T

“…Oligomerization and aggregation of α-synuclein molecules are believed to play a major role in neuronal dysfunction and loss in Parkinson's disease (PD) and…”
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The Co-chaperone Carboxyl Terminus of Hsp70-interacting Protein (CHIP) Mediates α-Synuclein Degradation Decisions between Proteasomal and Lysosomal Pathways by Shin, Youngah, Klucken, Jochen, Patterson, Cam, Hyman, Bradley T., McLean, Pamela J.

“…α-Synuclein is a major component of Lewy bodies, the pathological hallmark of Parkinson disease, dementia with Lewy bodies, and related disorders. Misfolding…”
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Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy by Spires, Tara L, Meyer-Luehmann, Melanie, Stern, Edward A, McLean, Pamela J, Skoch, Jesse, Nguyen, Paul T, Bacskai, Brian J, Hyman, Bradley T

“…Accumulation of amyloid-beta (Abeta) into senile plaques in Alzheimer's disease (AD) is a hallmark neuropathological feature of the disorder, which likely…”
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