Search Results - "McLean, Matthew A."

Use of surface plasmon resonance biosensor technology as a possible alternative to detect differences in binding of enantiomeric drug compounds to immobilized albumins by Ahmad, Ateeq, Ramakrishnan, Anand, McLean, Matthew A, Breau, Alan P

“…The use of biosensors for monitoring real time interactions between biomolecules and drug compounds has a lot of advantages over presently existing detection…”
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Quantitative Determination of Proteins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry by Nelson, Randall W, McLean, Matthew A, Hutchens, T. William

“…A method of protein quantitative analysis that uses matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is described. The method…”
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Plasma protein binding in drug discovery and development by Howard, Monique L, Hill, John J, Galluppi, Gerald R, McLean, Matthew A

“…This review describes methods for quantifying the binding of small molecule drug candidates to plasma proteins and the application of these methods in drug…”
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Accelerating drug development: methodology to support first-in-man pharmacokinetic studies by the use of drug candidate microdosing by McLean, Matthew A., Tam, Chi-Yan J., Baratta, Michael T., Holliman, Christopher L., Ings, Robert M., Galluppi, Gerald R.

“…Microdosing of experimental therapeutics in humans offers a number of benefits to the drug development process. Microdosing, conducted under an exploratory…”
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Use of Optical Biosensor Technology to Study Immunological Cross-Reactivity between Different Sulfonamide Drugs by Ahmad, Ateeq, Ramakrishnan, Anand, McLean, Matthew A., Li, Dongbei, Rock, Marie T., Karim, Aziz, Breau, Alan P.

“…Adverse reactions to medications account for a substantial number of hospitalizations and in some cases fatalities. The nature of the many drug–drug…”
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Analysis of residual trifluoroacetic acid in a phosphate-buffered saline matrix by ion chromatography with suppressed conductivity detection by Fernando, Peter N., McLean, Matthew A., Egwu, Ignatius N., deGuzman, Elena, Weyker, Cara

“…As part of the formulation of a cell-based pharmaceutical product, cells were harvested from mice and incubated in a cocktail containing cell culture media and…”
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Enhanced analysis of sulfonated azo dyes using liquid chromatography/thermospray mass spectrometry by McLean, Matthew A, Freas, Royal B

“…Modifications to a thermospray vaporizer probe and ion source have been made that enhance ion evaporation resulting in increased sample ion current. These…”
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