Search Results - "McLean, Larry R."

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule by Deng, Gejing, Shen, Junqing, Yin, Ming, McManus, Jessica, Mathieu, Magali, Gee, Patricia, He, Timothy, Shi, Chaomei, Bedel, Olivier, McLean, Larry R., Le-Strat, Frank, Zhang, Ying, Marquette, Jean-Pierre, Gao, Qiang, Zhang, Bailin, Rak, Alexey, Hoffmann, Dietmar, Rooney, Eamonn, Vassort, Aurelie, Englaro, Walter, Li, Yi, Patel, Vinod, Adrian, Francisco, Gross, Stefan, Wiederschain, Dmitri, Cheng, Hong, Licht, Stuart

“…Cancer-associated point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) confer a neomorphic enzymatic activity: the reduction of α-ketoglutarate…”
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Spectroscopic Methods for Analysis of Protein Secondary Structure by Pelton, John T., McLean, Larry R.

“…Several methods for determination of the secondary structure of proteins by spectroscopic measurements are reviewed. Circular dichroism (CD) spectroscopy…”
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Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators by Vaz, Roy J., Li, Yi, Chellaraj, Vinolia, Reiling, Stephan, Kuntzweiler, Theresa, Yang, Donglai, Shen, Hong, Batchelor, Joseph D., Zhang, Ying, Chen, Xin, McLean, Larry R., Kosley, Raymond

“…[Display omitted] •CYP3A4 induction data lead to PXR activation data for mGluR2 allosteric activators.•One of the compounds was also crystallized with PXR &…”
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X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase by McLean, Larry R., Zhang, Ying, Zaidi, Nisha, Bi, Xiping, Wang, Rachel, Dharanipragada, Ram, Jurcak, John G., Gillespy, Timothy A., Zhao, Zhicheng, Musick, Kwon Y., Choi, Yong-Mi, Barrague, Matthieu, Peppard, Jane, Smicker, Matthew, Duguid, Mei, Parkar, Ashfaq, Fordham, Jeremy, Kominos, Dorothea

“…Beginning with a screening hit, unique thienopyrazole-indole inhibitors of Itk (interleukin-2-inducible tyrosine kinase) were designed, synthesized, and…”
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Protein disulfide isomerase appears necessary to maintain the catalytically active structure of the microsomal triglyceride transfer protein by Wetterau, John R, Combs, Kelly A, McLean, Larry R, Spinner, Sara N, Aggerbeck, Lawrence P

“…Protein disulfide isomerase (PDI) is a component of the microsomal triglyceride transfer protein (MTP) complex. This study was initiated to help elucidate the…”
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Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening by McLean, Larry R., Zhang, Ying, Li, Hua, Li, Ziyu, Lukasczyk, Ulrike, Choi, Yong-Mi, Han, Zuoning, Prisco, Joy, Fordham, Jeremy, Tsay, Joseph T., Reiling, Stephan, Vaz, Roy J., Li, Yi

“…Virtual screen hits were shown to be covalent inhibitors by biochemical and X-ray crystallographic studies. Biochemical and X-ray crystallographic studies…”
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Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site by McLean, Larry R., Zhang, Ying, Li, Hua, Choi, Yong-Mi, Han, Zuoning, Vaz, Roy J., Li, Yi

“…Fragment screening by in silico docking followed by X-ray crystallography demonstrates the formation of a previously unreported surface binding site in MIF…”
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Influence of molecular packing and phospholipid type on rates of cholesterol exchange by Lund-Katz, Sissel, Laboda, Henry M, McLean, Larry R, Phillips, Michael C

“…The rates of [14C]cholesterol transfer from small unilamellar vesicles containing cholesterol dissolved in bilayers of different phospholipids have been…”
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Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures by McLean, Larry R., Zhang, Ying, Degnen, William, Peppard, Jane, Cabel, Dasha, Zou, Chao, Tsay, Joseph T., Subramaniam, Arun, Vaz, Roy J., Li, Yi

“…Several amino-benzoic acid derivatives were found to be DHODH inhibitors through virtual screening, biochemical, and X-ray crystallographic studies…”
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Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group by Liang, Guyan, Chen, Xin, Aldous, Suzanne, Pu, Su-Fen, Mehdi, Shujaath, Powers, Elaine, Giovanni, Andrew, Kongsamut, Sathapana, Xia, Tianhui, Zhang, Ying, Wang, Rachel, Gao, Zhongli, Merriman, Gregory, McLean, Larry R, Morize, Isabelle

“…A series of compounds with an amidinothiophene P1 group and a pyrrolidinone-sulphonamide scaffold linker was identified as potent inhibitors of human…”
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Structural properties of the microsomal triglyceride-transfer protein complex by Wetterau, John R, Aggerbeck, Lawrence P, Laplaud, P. Michel, McLean, Larry R

“…The microsomal triglyceride-transfer protein (MTP), which catalyzes the transport of triglyceride and cholesteryl ester between membranes, is a complex…”
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Effect of probucol on the physical properties of low-density lipoproteins oxidized by copper by McLean, Larry R, Hagaman, Karen A

“…Human plasma low-density lipoproteins (LDL) were incubated with 10 microM probucol for 1 h at 37 degrees C. Probucol incorporation into the LDL was complete as…”
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Kinetics of phosphatidylcholine and lysophosphatidylcholine exchange between unilamellar vesicles by McLean, Larry R, Phillips, Michael C

“…The rates of exchange of phosphatidylcholine and lysophosphatidylcholine from unilamellar donor vesicles to acceptor vesicles of similar composition were…”
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Spectra and physical properties of liposomes and monolayers of polymerizable phospholipids containing diacetylene groups in one or both acyl chains by Johnston, David Samuel, McLean, Larry R, Whittam, Mary A, Clark, Anthony D, Chapman, Dennis

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Ascorbate and phenolic antioxidant interactions in prevention of liposomal oxidation by Thomas, Craig E., McLean, Larry R., Parker, Roger A., Ohlweiler, David F.

“…Efficient prevention of membrane lipid peroxidation by vitamin E (α‐tocopherol) may involve its regeneration by vitamin C (ascorbate). Conceivably, the…”
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Minimal peptide length for interaction of amphipathic .alpha.-helical peptides with phosphatidylcholine liposomes by McLean, Larry R, Hagaman, Karen A, Owen, Thomas J, Krstenansky, John L

“…The interactions of a series of amphipathic alpha-helical peptides containing from 6 to 18 amino acid residues with dipalmitoylphosphatidylcholine (DPPC) and…”
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Identification of a Model Cardiac Glycoside Receptor:  Comparisons with Na+,K+-ATPase by Kasturi, Rama, Yuan, Jie, McLean, Larry R, Margolies, Michael N, Ball, William J

“…The availability of high-affinity anti-digoxin monoclonal antibodies (mAbs) offers the potential for their use as models for the characterization of the…”
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Examination of the role of the amphipathic .alpha.-helix in the interaction of neuropeptide Y and active cyclic analogs with cell membrane receptors and dimyristoylphosphatidylcholine by McLean, Larry R, Buck, Stephen H, Krstenansky, John L

“…To test the potential importance of the putative C-terminal amphipathic alpha-helical region of neuropeptide Y (NPY) in receptor binding, the interactions of…”
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Micelle-bound conformations of a bombesin/gastrin releasing peptide receptor agonist and an antagonist by two-dimensional NMR and restrained molecular dynamics by Malikayil, J. A, Edwards, J. Vincent, McLean, Larry R

“…Two nonapeptide analogs of the carboxyl termini of bombesin (Bn) and gastrin releasing peptide (GRP) have been synthesized. Despite the small difference in…”
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Heparin prevents the binding of phospholipase A2 to phospholipid micelles: importance of the amino-terminus by Dicciaani, Mitchell B, Lilly-Stauderman, Martha, McLean, Larry R, Balasubramaniam, Ambikaipakan, Harmony, Judith A. K

“…The activity of the major isoform of porcine pancreatic phospholipase A2 (PLA2), designated B-PLA2, against micellar substrates is inhibited by heparin…”
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