Search Results - "McLean, Irwin W.H."

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention by Simpson, Eric L., MD, MCR, Chalmers, Joanne R., PhD, Hanifin, Jon M., MD, Thomas, Kim S., PhD, Cork, Michael J., PhD, FRCP, McLean, W.H. Irwin, FRSE, FMedSci, Brown, Sara J., MRCP, MD, Chen, Zunqiu, MS, Chen, Yiyi, PhD, Williams, Hywel C., DSc, FMedSci

“…Background Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in children worldwide and is…”
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Atopic Dermatitis and Disease Severity Are the Main Risk Factors for Food Sensitization in Exclusively Breastfed Infants by Flohr, Carsten, Perkin, Michael, Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Campbell, Linda E., MacCallum, Stephanie F., Irwin McLean, W.H., Lack, Gideon

“…Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated…”
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Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy by Brough, Helen A., MSc, FRCPCH, Liu, Andrew H., MD, Sicherer, Scott, MD, Makinson, Kerry, MSc, Douiri, Abdel, PhD, Brown, Sara J., MD, Stephens, Alick C., PhD, Irwin McLean, W.H., PhD, DSc, FRSE, FMedSci, Turcanu, Victor, PhD, Wood, Robert A., MD, Jones, Stacie M., MD, Burks, Wesley, MD, Dawson, Peter, PhD, Stablein, Donald, PhD, Sampson, Hugh, MD, Lack, Gideon, MD

“…Background History and severity of atopic dermatitis (AD) are risk factors for peanut allergy. Recent evidence suggests that children can become sensitized to…”
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The persistence of atopic dermatitis and filaggrin ( FLG ) mutations in a US longitudinal cohort by Margolis, David J., MD, PhD, Apter, Andrea J., MD, MSc, Gupta, Jayanta, MD, PhD, Hoffstad, Ole, MS, Papadopoulos, Maryte, BA, Campbell, Linda E., BA, Sandilands, Aileen, PhD, McLean, W.H. Irwin, PhD, DSc, Rebbeck, Tim R., PhD, Mitra, Nandita, PhD

“…Background Atopic dermatitis (AD) is a common skin disease that is characterized by recurrent episodes of itching. Filaggrin ( FLG ) loss-of-function ( FLG…”
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Filaggrin mutations, atopic eczema, hay fever, and asthma in children by Weidinger, Stephan, MD, O'Sullivan, Maureen, MD, Illig, Thomas, PhD, Baurecht, Hansjörg, MSc, Depner, Martin, MSc, Rodriguez, Elke, MSc, Ruether, Andreas, PhD, Klopp, Norman, PhD, Vogelberg, Christian, MD, Weiland, Stephan K., MD, McLean, W.H. Irwin, PhD, DSc, FRSE, von Mutius, Erika, MD, Irvine, Alan D., MD, Kabesch, Michael, MD

“…Background Mutations in the filaggrin gene ( FLG ) have been shown to play a significant role in ichthyosis vulgaris and eczema, 2 common chronic skin…”
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Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes by O'Regan, Gráinne M., MRCPI, Kemperman, Patrick M.J.H., MD, Sandilands, Aileen, PhD, Chen, Huijia, MD, Campbell, Linda E., BSc, Kroboth, Karin, PhD, Watson, Rosemarie, MD, Rowland, Marion, MB, PhD, Puppels, Gerwin J., PhD, McLean, W.H. Irwin, DSc, FMedSci, Caspers, Peter J., PhD, Irvine, Alan D., MD, FRCPI

“…Background Filaggrin ( FLG ) has a central role in the pathogenesis of atopic dermatitis (AD). FLG is a complex repetitive gene; highly population-specific…”
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Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita by Leachman, Sancy A, Hickerson, Robyn P, Hull, Peter R, Smith, Frances J.D, Milstone, Leonard M, Lane, E. Birgitte, Bale, Sherri J, Roop, Dennis R, McLean, W.H. Irwin, Kaspar, Roger L

“…Summary The field of science and medicine has experienced a flood of data and technology associated with the human genome project. Over 10,000 human diseases…”
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Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year by Kennedy, Elizabeth A., BS, Connolly, Jennifer, MSc, Hourihane, Jonathan O'B., DM, Fallon, Padraic G., PhD, McLean, W.H. Irwin, DSc, FRS, Murray, Deirdre, PhD, Jo, Jay-Hyun, PhD, Segre, Julia A., PhD, Kong, Heidi H., MD, MHSc, Irvine, Alan D., MD, DSc

“…Background Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus…”
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Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year by Kelleher, Maeve, MB, Dunn-Galvin, Audrey, PhD, Hourihane, Jonathan O'B., DM, Murray, Deirdre, MD, Campbell, Linda E., BSc, McLean, W.H. Irwin, DSc, FRS, Irvine, Alan D., MD

“…Background Loss-of-function mutations in the skin barrier protein filaggrin ( FLG ) are a major risk for atopic dermatitis (AD). The pathogenic sequence of…”
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Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations by Brough, Helen A., MSc, FRCPCH, Simpson, Angela, MD, PhD, Makinson, Kerry, MSc, Hankinson, Jenny, PhD, Brown, Sara, MD, Douiri, Abdel, PhD, Belgrave, Danielle C.M., MSc, Penagos, Martin, MD, MSc, Stephens, Alick C., PhD, McLean, W.H. Irwin, PhD, DSc, FRSE, FMedSci, Turcanu, Victor, PhD, Nicolaou, Nicolaos, MD, PhD, Custovic, Adnan, MD, PhD, Lack, Gideon, MD, FRCPCH

“…Background Filaggrin (FLG) loss-of-function mutations lead to an impaired skin barrier associated with peanut allergy. Household peanut consumption is…”
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Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient by BERNASSOLA, FRANCESCA, FEDERICI, MASSIMO, CORAZZARI, MARCO, TERRINONI, ALESSANDRO, HRIBAL, MARTA L., DE LAURENZI, VINCENZO, RANALLI, MARCO, MASSA, ORNELLA, SESTI, GIORGIO, MCLEAN, W.H. IRWIN, CITRO, GENNARO, BARBETTI, FABRIZIO, MELINO, GERRY

“…ABSTRACT Transglutaminase 2 (TGase 2) is a Ca+2‐ dependent enzyme that catalyzes both intracellular and extracellular cross‐linking reactions by transamidation…”
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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes by Schmitt, Jochen, MD, MPH, Schwarz, Kristin, MSc, Baurecht, Hansjörg, MSc, Hotze, Melanie, MSc, Fölster-Holst, Regina, MD, Rodríguez, Elke, PhD, Lee, Young A.E., MD, Franke, Andre, PhD, Degenhardt, Frauke, MSc, Lieb, Wolfgang, PhD, Gieger, Christian, PhD, Kabesch, Michael, MD, Nöthen, Markus M., MD, Irvine, Alan D., MD, McLean, W.H. Irwin, PhD, Deckert, Stefanie, MPH, Stephan, Victoria, Schwarz, Peter, MD, Aringer, Martin, MD, Novak, Natalija, MD, Weidinger, Stephan, MD, MaHM

“…Background Atopic dermatitis (AD) is characterized by epidermal barrier failure and immune-mediated inflammation. Evidence on AD as a potential risk factor for…”
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A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita by Liao, Haihui, Sayers, Jane M, Wilson, Neil J, Irvine, Alan D, Mellerio, Jemima E, Baselga, Eulalia, Bayliss, Susan J, Uliana, Vera, Fimiani, Michele, Lane, E. Birgitte, McLean, W.H. Irwin, Leachman, Sancy A, Smith, Frances J.D

“…Summary Background Pachyonychia congenita (PC) is a rare autosomal dominant keratin disorder, subdivided into two major variants, PC-1 and PC-2. Predominant…”
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Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis by Cole, Christian, PhD, Kroboth, Karin, MSc, Schurch, Nicholas J., PhD, Sandilands, Aileen, PhD, Sherstnev, Alexander, PhD, O'Regan, Grainne M., MRCPI, Watson, Rosemarie M., MD, Irwin McLean, W.H., DSc, Barton, Geoffrey J., PhD, Irvine, Alan D., MD, Brown, Sara J., MD

“…Background Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin…”
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Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis by Riethmuller, Christoph, PhD, McAleer, Maeve A., MRCP, Koppes, Sjors A., MD, Abdayem, Rawad, MSc, Franz, Jonas, Haftek, Marek, MD, PhD, Campbell, Linda E., MSc, MacCallum, Stephanie F., BSc, McLean, W.H. Irwin, PhD, DSc, FRS, FRSE, FMedSci, Irvine, Alan D., MD, Kezic, Sanja, PhD

“…Background Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk factor for atopic dermatitis (AD) and are known to cause an…”
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Gentamicin-Induced Readthrough and Nonsense-Mediated mRNA Decay of SERPINB7 Nonsense Mutant Transcripts by Ohguchi, Yuka, Nomura, Toshifumi, Suzuki, Shotaro, Takeda, Masae, Miyauchi, Toshinari, Mizuno, Osamu, Shinkuma, Satoru, Fujita, Yasuyuki, Nemoto, Osamu, Ono, Kota, McLean, W.H. Irwin, Shimizu, Hiroshi

“…Nagashima-type palmoplantar keratosis (NPPK) is an autosomal recessive skin disorder with a high, unmet medical need that is caused by mutations in SERPINB7…”
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Filaggrin in atopic dermatitis by O'Regan, Grainne M., MB, Sandilands, Aileen, PhD, McLean, W.H. Irwin, PhD, DSc, Irvine, Alan D., MD, FRCPI

“…The recent identification of loss-of-function mutations in the structural protein filaggrin as a widely replicated major risk factor for eczema sheds new light…”
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Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function by Gruber, Robert, Elias, Peter M, Crumrine, Debra, Lin, Tzu-Kai, Brandner, Johanna M, Hachem, Jean-Pierre, Presland, Richard B, Fleckman, Philip, Janecke, Andreas R, Sandilands, Aileen, McLean, W.H. Irwin, Fritsch, Peter O, Mildner, Michael, Tschachler, Erwin, Schmuth, Matthias

“…Although it is widely accepted that filaggrin (FLG) deficiency contributes to an abnormal barrier function in ichthyosis vulgaris and atopic dermatitis, the…”
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Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin by McAleer, Maeve A., MB, MRCP, Pohler, Elizabeth, PhD, Smith, Frances J.D., PhD, Wilson, Neil J., MSc, Cole, Christian, PhD, MacGowan, Stuart, PhD, Koetsier, Jennifer L., BS, Godsel, Lisa M., PhD, Harmon, Robert M., PhD, Gruber, Robert, MD, Crumrine, Debra, BS, Elias, Peter M., MD, McDermott, Michael, FRCPath, Butler, Karina, FRCPI, Broderick, Annemarie, MRCPI, Sarig, Ofer, PhD, Sprecher, Eli, MD, PhD, Green, Kathleen J., PhD, McLean, W.H. Irwin, PhD, DSc, FRS, FRSE, FMedSci, Irvine, Alan D., MD

“…Background Severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome is a recently recognized syndrome caused by mutations in the desmoglein…”
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Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study by Perkin, Michael R., PhD, Craven, Joanna, MPH, Logan, Kirsty, PhD, Strachan, David, MD, Marrs, Tom, BM BS, Radulovic, Suzana, MD, Campbell, Linda E., BSc, MacCallum, Stephanie F., MSc, McLean, W.H. Irwin, DSc, Lack, Gideon, MD, Flohr, Carsten, PhD

“…Background Domestic water hardness and chlorine have been suggested as important risk factors for atopic dermatitis (AD). Objective We sought to examine the…”
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