Search Results - "McLean, David L"

Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish by Menelaou, Evdokia, McLean, David L.

“…In all vertebrates, excitatory spinal interneurons execute dynamic adjustments in the timing and amplitude of locomotor movements. Currently, it is unclear…”
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Integrated one- and two-photon scanned oblique plane illumination (SOPi) microscopy for rapid volumetric imaging by Kumar, Manish, Kishore, Sandeep, Nasenbeny, Jordan, McLean, David L, Kozorovitskiy, Yevgenia

“…Versatile, sterically accessible imaging systems capable of in vivo rapid volumetric functional and structural imaging deep in the brain continue to be a…”
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Selective Responses to Tonic Descending Commands by Temporal Summation in a Spinal Motor Pool by Wang, Wei-Chun, McLean, David L.

“…Motor responses of varying intensities rely on descending commands to heterogeneous pools of motoneurons. In vertebrates, numerous sources of descending…”
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Visual Threat Assessment and Reticulospinal Encoding of Calibrated Responses in Larval Zebrafish by Bhattacharyya, Kiran, McLean, David L., MacIver, Malcolm A.

“…All visual animals must decide whether approaching objects are a threat. Our current understanding of this process has identified a proximity-based mechanism…”
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Modular Organization of Axial Microcircuits in Zebrafish by Bagnall, Martha W., McLean, David L.

“…Locomotion requires precise control of spinal networks. In tetrapods and bipeds, dynamic regulation of locomotion is simplified by the modular organization of…”
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A gradient in endogenous rhythmicity and oscillatory drive matches recruitment order in an axial motor pool by Menelaou, Evdokia, McLean, David L

“…The rhythmic firing behavior of spinal motoneurons is a function of their electrical properties and synaptic inputs. However, the relative contribution of…”
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Peeling back the layers of locomotor control in the spinal cord by McLean, David L, Dougherty, Kimberly J

“…Highlights • Limb and axial motor pool coordination are simplified by spinal network modularity. • Different spinal modules are deployed at increasing speeds…”
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Integration of Swimming-Related Synaptic Excitation and Inhibition by olig2 + Eurydendroid Neurons in Larval Zebrafish Cerebellum by Harmon, Thomas C, McLean, David L, Raman, Indira M

“…The cerebellum influences motor control through Purkinje target neurons, which transmit cerebellar output. Such output is required, for instance, for larval…”
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Spinal Interneurons Differentiate Sequentially from Those Driving the Fastest Swimming Movements in Larval Zebrafish to Those Driving the Slowest Ones by McLean, David L, Fetcho, Joseph R

“…Studies of neuronal networks have revealed few general principles that link patterns of development with later functional roles. While investigating the neural…”
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Central and peripheral innervation patterns of defined axial motor units in larval zebrafish by Bello‐Rojas, Saul, Istrate, Ana E., Kishore, Sandeep, McLean, David L.

“…Spinal motor neurons and the peripheral muscle fibers they innervate form discrete motor units that execute movements of varying force and speed. Subsets of…”
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Mixed synapses reconcile violations of the size principle in zebrafish spinal cord by Menelaou, Evdokia, Kishore, Sandeep, McLean, David L

“…Mixed electrical-chemical synapses potentially complicate electrophysiological interpretations of neuronal excitability and connectivity. Here, we disentangle…”
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A topographic map of recruitment in spinal cord by Higashijima, Shin-ichi, Fan, Jingyi, Hale, Melina E, Fetcho, Joseph R, McLean, David L

“…Animals move over a range of speeds by using rhythmic networks of neurons located in the spinal cord. Here we use electrophysiology and in vivo imaging in…”
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Visually guided gradation of prey capture movements in larval zebrafish by Patterson, Bradley W, Abraham, Aliza O, MacIver, Malcolm A, McLean, David L

“…A mechanistic understanding of goal-directed behavior in vertebrates is hindered by the relative inaccessibility and size of their nervous systems. Here, we…”
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Distinct responses of Purkinje neurons and roles of simple spikes during associative motor learning in larval zebrafish by Harmon, Thomas C, Magaram, Uri, McLean, David L, Raman, Indira M

“…To study cerebellar activity during learning, we made whole-cell recordings from larval zebrafish Purkinje cells while monitoring fictive swimming during…”
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Systematic shifts in the balance of excitation and inhibition coordinate the activity of axial motor pools at different speeds of locomotion by Kishore, Sandeep, Bagnall, Martha W, McLean, David L

“…An emerging consensus from studies of axial and limb networks is that different premotor populations are required for different speeds of locomotion. An…”
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Continuous shifts in the active set of spinal interneurons during changes in locomotor speed by Lindquist, W Brent, Fetcho, Joseph R, McLean, David L, Masino, Mark A, Koh, Ingrid Y Y

“…The authors here show that two completely different classes of spinal premotor interneurons drive motoneurons during slow and fast swimming of zebrafish…”
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Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish by McLean, David L., Fetcho, Joseph R.

“…We report the development of aminergic neurons from 0–10 days postfertilization (dpf) in zebrafish (Danio rerio). This study was prompted by the lack of…”
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Neuromodulation: Letting Sources of Spinal Dopamine Speak for Themselves by Kishore, Sandeep, McLean, David L.

“…A recent study of dopaminergic neurons in the brain of larval zebrafish has important implications for interpreting the natural actions of neuromodulators in…”
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Speed Control: Spinal Interneurons with Crossed Purposes by Menelaou, Evdokia, McLean, David L.

“…A recent study has revealed that different populations of commissural spinal interneurons ensure limb alternation at different speeds of locomotion…”
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Optogenetics: Illuminating Sources of Locomotor Drive by McLean, David L.

“…A recent study has used optogenetics to identify the source of excitatory drive for locomotion in zebrafish, revealing unexpected differences in the command…”
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