Search Results - "McLean, Adam G"

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis by Gale, Daniel P, MRCP, de Jorge, Elena Goicoechea, PhD, Cook, H Terence, Prof, Martinez-Barricarte, Rubén, PhD, Hadjisavvas, Andreas, PhD, McLean, Adam G, FRCP, Pusey, Charles D, Prof, Pierides, Alkis, FRCP, Kyriacou, Kyriacos, PhD, Athanasiou, Yiannis, MD, Voskarides, Konstantinos, PhD, Deltas, Constantinos, Prof, Palmer, Andrew, FRCP, Frémeaux-Bacchi, Véronique, PhD, de Cordoba, Santiago Rodriguez, Prof, Maxwell, Patrick H, Prof, Pickering, Matthew C, Prof

“…Summary Background Complement is a key component of the innate immune system, and variation in genes that regulate its activation is associated with renal and…”
Get full text

High Intrapatient Variability of Tacrolimus Levels and Outpatient Clinic Nonattendance Are Associated With Inferior Outcomes in Renal Transplant Patients by Goodall, Dawn L., Willicombe, Michelle, McLean, Adam G., Taube, David

“…Nonadherence to immunosuppressants is associated with rejection and allograft loss. Intrapatient variability (IPV) of immunosuppression levels is a marker of…”
Get full text

Antibody Removal Before ABO-Incompatible Renal Transplantation: How Much Plasma Exchange Is Therapeutic? by LAWRENCE, Christopher, GALLIFORD, Jaek W, WILLIEOMBE, Michelle K, MELEAN, Adam G, LESABE, Mary, ROWAN, Fiona, PAPALOIS, Vassilios, REGAN, Fiona, TAUBE, David

“…ABOi transplantation is an accepted method of expanding the kidney donor pool but there is little analysis of the protocols used. We established an ABOi…”
Get full text

Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy by Medjeral-Thomas, Nicholas R, Lomax-Browne, Hannah J, Beckwith, Hannah, Willicombe, Michelle, McLean, Adam G, Brookes, Paul, Pusey, Charles D, Falchi, Mario, Cook, H Terence, Pickering, Matthew C

“…IgA nephropathy (IgAN) is a common cause of chronic kidney disease and end-stage renal failure, especially in young people. Due to a wide range of clinical…”
Get more information

Paraprotein ‘zippers’ by Bravou, Vasiliki, McLean, Adam G., Loucaidou, Marina, Cairns, Tom D., Cook, Herbert T., Roufosse, Candice A.

Get full text

Alemtuzumab dose adjusted for body weight is associated with earlier lymphocyte repletion and less infective episodes in the first year post renal transplantation - a retrospective study by Willicombe, Michelle, Goodall, Dawn, McLean, Adam G, Taube, David

“…The optimal dose of alemtuzumab for renal transplant induction is not known, and the doses reported in the literature vary. This study compares two separate…”
Get more information

Acute Cellular Rejection: Impact of Donor-Specific Antibodies and C4d by Willicombe, Michelle, Roufosse, Candice, Brookes, Paul, McLean, Adam G, Galliford, Jack, Cairns, Tom, Cook, Terry H, Taube, David

“…BACKGROUNDMixed rejection in kidney transplantation consists of histologic and/or serological evidence of both cellular and humoral components. As it is not…”
Get full text

Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies by Willicombe, Michelle, Moss, Jill, Moran, Linda, Brookes, Paul, Santos-Nunez, Eva, McLean, Adam G, Cairns, Thomas, Taube, David, Cook, Terence H, Roufosse, Candice

“…The presence of tubuloreticular inclusions (TRIs) in native glomerular endothelial cells associates with viral infections and lupus nephritis. However, the…”
Get full text

Incidence, risk factors, and outcomes of stroke post-transplantation in patients receiving a steroid sparing immunosuppression protocol by Willicombe, Michelle, Kumar, Nicola, Goodall, Dawn, Clarke, Candice, McLean, Adam G., Power, Albert, Taube, David

“…Corticosteroid use after transplantation is associated with an increased incidence of cardiovascular events and death. Cerebrovascular disease is a common…”
Get full text

Use of Quantitative Real Time Polymerase Chain Reaction to Assess Gene Transcripts Associated With Antibody-Mediated Rejection of Kidney Transplants by Dominy, Katherine M, Roufosse, Candice, de Kort, Hanneke, Willicombe, Michelle, Brookes, Paul, Behmoaras, Jacques V, Petretto, Enrico G, Galliford, Jack, Choi, Peter, Taube, David, Cook, H Terence, Mclean, Adam G

“…Microarray studies have shown elevated transcript levels of endothelial and natural killer (NK) cell-associated genes during antibody-mediated rejection (AMR)…”
Get full text

Peritubular Capillary Basement Membrane Multilayering in Renal Allograft Biopsies of Patients With De Novo Donor-Specific Antibodies by de Kort, Hanneke, Willicombe, Michelle, Brookes, Paul, Moran, Linda B, Santos-Nunez, Eva, Galliford, Jack W, Taube, David, McLean, Adam G, Moss, Jill, Cook, H Terence, Roufosse, Candice

“…BACKGROUNDSevere peritubular capillary basement membrane multilayering (PTCBML) is part of the Banff definition of chronic antibody-mediated rejection. We…”
Get full text

Antibody-Mediated Rejection After Alemtuzumab Induction: Incidence, Risk Factors, and Predictors of Poor Outcome by WILLICOMBE, Michelle, ROUFOSSE, Candice, BROOKES, Paul, GALLIFORD, Jack W, MCLEAN, Adam G, DORLING, Anthony, WARRENS, Anthony N, COOK, Terry H, CAIRNS, Tom D, TAUBE, David

“…Antibody-mediated rejection (AMR) is associated with allograft loss. Identification of factors associated with poor outcome has not been extensively studied…”
Get full text

Kidney Transplantation With Minimized Maintenance: Alemtuzumab Induction With Tacrolimus Monotherapy—An Open Label, Randomized Trial by CHAN, Kakit, TAUBE, David, HAKIM, Nadey, PALMER, Andrew, PAPALOIS, Vassilios, WARRENS, Anthony N, WILLICOMBE, Michelle, MCLEAN, Adam G, ROUFOSSE, Candice, COOK, Terence, BROOKES, Paul, GOODALL, Dawn, GALLIFORD, Jack, CAIRNS, Tom, DORLING, Anthony, DUNCAN, Neill

“…Immunosuppressive regimens for kidney transplantation which reduce the long-term burden of immunosuppression are attractive, but little data are available to…”
Get full text

Peritubular Capillary Basement Membrane Multilayering on Electron Microscopy: A Useful Marker of Early Chronic Antibody-Mediated Damage by ROUFOSSE, Candice A, SHORE, Ian, TAUBE, David, TERENCE COOK, H, MOSS, Jill, MORAN, Linda B, WILLICOMBE, Michelle, GALLIFORD, Jack, CHAN, Ka-Kit K, BROOKES, Paul A, DE KORT, Hanneke, MCLEAN, Adam G

“…Chronic antibody-mediated rejection is an important cause of late graft failure. Developing an early marker of the disease may allow diagnosis and treatment…”
Get full text

Changes in lipoprotein profile and urinary albumin excretion in familial LCAT deficiency with lipid lowering therapy by Yee, Michael S, Pavitt, Darrell V, Richmond, William, Cook, H. Terence, McLean, Adam G, Valabhji, Jonathan, Elkeles, Robert S

“…Abstract Familial lecithin:cholesterol acyltransferase deficiency (FLD) is a monogenic autosomal recessive condition, affecting cholesterol esterification and…”
Get full text

Treatment of focal and segmental glomerulosclerosis in adults with tacrolimus monotherapy by Duncan, Neill, Dhaygude, Ajay, Owen, Jane, Cairns, Thomas D. H., Griffith, Megan, McLean, Adam G., Palmer, Andrew, Taube, David

“…Background. Focal segmental glomerulosclerosis (FSGS) commonly presents with nephrotic syndrome (NS), and spontaneous remission is rare. NS is a poor…”
Get full text

Effects of lactate-buffered and lactate-free dialysate in CAVHD patients with and without liver dysfunction by McLean, Adam G., Davenport, Andrew, Cox, Dominic, Sweny, Paul

“…Effects of lactate-buffered and lactate-free dialysate in CAVHD patients with and without liver dysfunction. Continuous modalities of renal replacement deplete…”
Get full text

Tesio-Caths provide effective and safe long-term vascular access by Duncan, Neill D. C., Singh, Seema, Cairns, Thomas D. H., Clark, Martin, El-Tayar, Adil, Griffith, Megan, Hakim, Nadey, Hamady, Mohamad, McLean, Adam G., Papalois, Vassilios, Palmer, Andrew, Taube, David

“…Background. Vascular access is judged on its ability to provide good dialysis adequacy, its durability and complication rates. Formation of a functional…”
Get full text

Ethnicity and survival on dialysis in west London by Prasad, Shilpanjali, Singh, Seema, Duncan, Neill, Cairns, Tom D.H., Griffith, Megan, Hakim, Nadey, Mclean, Adam G., Palmer, Andrew, Papalois, Vassilios, Taube, David

“…Ethnicity and survival on dialysis in west London. Indo-Asian and Afro-Caribbean patients have higher rates of renal failure and requirement for renal…”
Get full text

Outcome of renal transplantation in South Asian recipients is similar to that in non-asians by LOUCAIDOU, Marina, PRASAD, Shilpanjali, VAN TROMP, Jen, CAIRNS, Tom D. H, GRIFFITH, Megan, HAKIM, Nadey, MCLEAN, Adam G, PALMER, Andrew, PAPALOIS, Vassilios, TAUBE, David

“…The United Kingdom has a large South Asian population, in which there is a high rate of renal disease and which forms a significant percentage of the renal…”
Get full text