Search Results - "McLaughlin, Patricia"

Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery Following Hypoxia-Ischemic Stroke in Type-2 Diabetic Mice by Kumari, Rashmi, Kareem, Zainab Y., McLaughlin, Patricia J.

“…Diabetic patients experience significant mortality and poor recovery following ischemic stroke. Our clinical and basic science studies demonstrate an overall…”
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Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain by Kareem, Zainab Y., McLaughlin, Patricia J., Kumari, Rashmi

“…The opioid growth factor (OGF) is an endogenous peptide that binds to the nuclear-associated receptor (OGFr), and plays a significant role in the proliferation…”
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Topical naltrexone increases aquaporin 5 production in the lacrimal gland and restores tear production in diabetic rats by Diaz, David, Sassani, Joseph P, Zagon, Ian S, McLaughlin, Patricia J

“…Diabetes mellitus is a prevalent disease that is often accompanied by ocular surface abnormalities including delayed epithelial wound healing and decreased…”
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Featured Article: Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone by Ludwig, Michael D, Zagon, Ian S, McLaughlin, Patricia J

“…Low-dose naltrexone is a widely used off-label therapeutic prescribed for a variety of immune-related disorders. The mechanism underlying low-dose naltrexone’s…”
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Ocular surface complications in diabetes: The interrelationship between insulin and enkephalin by Purushothaman, Indira, Zagon, Ian S., Sassani, Joseph W., McLaughlin, Patricia J.

“…The insulin pathway and the OGF-OGFr axis word in parallel with regard to formation of ocular surface complications in diabetes. [Display omitted] Diabetes is…”
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Intermittent blockade of OGFr and treatment of autoimmune disorders by Zagon, Ian S, McLaughlin, Patricia J

“…The opioid growth factor (OGF)–OGF receptor (OGFr) axis is present in normal and abnormal cells and tissues, and functions to maintain homeostatic cell…”
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Duration of opioid receptor blockade determines biotherapeutic response by McLaughlin, Patricia J., Zagon, Ian S.

“…Historically, studies on endogenous and exogenous opioids and their receptors focused on the mediation of pain, with excess opiate consumption leading to…”
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Blockade of OGFr delays the onset and reduces the severity of diabetic ocular surface complications by Zagon, Ian S, Sassani, Joseph W, Purushothaman, Indira, McLaughlin, Patricia J

“…The opioid growth factor (OGF)–OGF receptor (OGFr) pathway is present in the ocular surface and functions to maintain homeostasis of the epithelium. The…”
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The opioid growth factor–opioid growth factor receptor axis: Homeostatic regulator of cell proliferation and its implications for health and disease by McLaughlin, Patricia J., Zagon, Ian S.

“…The opioid growth factor (OGF), chemically termed [Met5]-enkephalin, is an endogenous opioid peptide that interacts with the OGF receptor (OGFr) to delay the…”
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Dysregulation of the OGF–OGFr pathway correlates with elevated serum OGF and ocular surface complications in the diabetic rat by Zagon, Ian S, Sassani, Joseph W, Purushothaman, Indira, McLaughlin, Patricia J

“…Diabetes often presents with ocular surface complications including dry eye, keratopathy, and altered sensitivity, along with systemic disorders. A common…”
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Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini-pigs by McLaughlin, Patricia J, Sassani, Joseph W, Zagon, Ian S

“…This study was conducted to determine the safety of topical naltrexone treatment in Göttingen swine. Efficacy of topical naltrexone was performed previously in…”
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Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis by Patel, Chirag, Zagon, Ian S., Pearce‐Clawson, Mason, McLaughlin, Patricia J.

“…Multiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that primarily affects women during the second or third decade of life…”
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Sex differences in the magnitude of diabetic ocular surface complications: Role of serum OGF by Purushothaman, Indira, Zagon, Ian S., Sassani, Joseph W, Zhou, Shouhao, McLaughlin, Patricia J

“…•Chronic hyperglycemia (T1D) affects male and female rats differently.•OGF serum levels are elevated, sex hormone levels are decreased in T1D.•Female T1D rats…”
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Ocular surface complications result from dysregulation of the OGF-OGFr signaling pathway in female diabetic rats by Purushothaman, Indira, Zagon, Ian S, Sassani, Joseph W, Mclaughlin, Patricia J

“…Approximately 4.5 million women in the United States exhibit diabetes-associated ocular complications. The time course and magnitude of these complications,…”
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Elevated serum [Met5 ]-enkephalin levels correlate with improved clinical and behavioral outcomes in experimental autoimmune encephalomyelitis by Ludwig, Michael D, Zagon, Ian S, McLaughlin, Patricia J

“…Highlights • Serum [Met5 ]-enkephalin concentrations decline with EAE disease. • OGF therapy reverses EAE progression and increases serum enkephalin levels. •…”
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Low-dose naltrexone reduced anxiety in persons with multiple sclerosis during the COVID-19 pandemic by McLaughlin, Patricia J., Odom, Laura B., Arnett, Peter A., Orehek, Shannon, Thomas, Gary A., Zagon, Ian S.

“…Persons with multiple sclerosis (PwMS) have been considered at high risk for vaccination and/or acquisition of COVID-19 related to their reduced immune systems…”
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Opioid growth factor and low-dose naltrexone impair central nervous system infiltration by CD4 + T lymphocytes in established experimental autoimmune encephalomyelitis, a model of multiple sclerosis by Hammer, Leslie A, Waldner, Hanspeter, Zagon, Ian S, McLaughlin, Patricia J

“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by infiltrating myelin-reactive T lymphocytes and…”
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Opioid growth factor and the treatment of human pancreatic cancer:A review by Zagon, Ian S, McLaughlin, Patricia J

“…Opioid growth factor(OGF),chemically termed[Met5]-enkephalin,and its receptor,OGF receptor(OGFr),form a biological axis that tonically regulates cell…”
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Featured Article: Modulation of the OGF–OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis by Ludwig, Michael D, Zagon, Ian S, McLaughlin, Patricia J

“…The endogenous neuropeptide opioid growth factor, chemically termed [Met5]-enkephalin, has growth inhibitory and immunomodulatory properties. Opioid growth…”
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Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer by Zagon, Ian S, Donahue, Renee, McLaughlin, Patricia J

“…The opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis is a biological pathway that is present in human ovarian cancer cells and tissues…”
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