Search Results - "McLaughlin, Nathan J. D."

Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation by Sheppard, Forest R., Kelher, Marguerite R., Moore, Ernest E., McLaughlin, Nathan J. D., Banerjee, Anirban, Silliman, Christopher C.

“…The reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is part of the microbicidal arsenal used by human polymorphonuclear neutrophils (PMNs)…”
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LysoPCs induce Hck‐ and PKCδ‐mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils by Kelher, Marguerite R., McLaughlin, Nathan J. D., Banerjee, Anirban, Elzi, David J., Gamboni, Fabia, Khan, Samina Y., Meng, Xianzhong, Mitra, Sanchayita, Silliman, Christopher C.

“…Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion‐related acute lung injury (TRALI)…”
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Platelet-Activating Factor-Induced Clathrin-Mediated Endocytosis Requires beta-Arrestin-1 Recruitment and Activation of the p38 MAPK Signalosome at the Plasma Membrane for Actin Bundle Formation by McLaughlin, Nathan J. D, Banerjee, Anirban, Kelher, Marguerite R, Gamboni-Robertson, Fabia, Hamiel, Christine, Sheppard, Forest R, Moore, Ernest E, Silliman, Christopher C

“…Clathrin-mediated endocytosis (CME) is a common pathway used by G protein-linked receptors to transduce extracellular signals. We hypothesize that…”
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Transfusion-related acute lung injury by Silliman, Christopher C., McLaughlin, Nathan J.D.

“…Transfusion-related acute lung injury (TRALI) is a life-threatening adverse event of transfusion, which has an increasing incidence in the United States and is…”
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Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation by Silliman, Christopher C., Kelher, Marguerite R., Khan, Samina Y., West, F. Bernadette, McLaughlin, Nathan J.D., Elzi, David J., England, Kelly, Bjornsen, Jason, Kuldanek, Susan A., Banerjee, Anirban

“…BACKGROUND Although transfusion is a lifesaving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored…”
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Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils by Eckels, Phillip C, Banerjee, Anirban, Moore, Ernest E, McLaughlin, Nathan J D, Gries, Lynn M, Kelher, Marguerite R, England, Kelly M, Gamboni-Robertson, Fabia, Khan, Samina Y, Silliman, Christopher C

“…Receptor signaling is integral for adhesion, emigration, phagocytosis, and reactive oxygen species production in polymorphonuclear neutrophils (PMNs). Priming…”
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A two-event In vitro model of acute chest syndrome: The role of secretory phospholipase A2 and neutrophils by Ball, J. Bradley, Khan, Samina Y., McLaughlin, Nathan J.D., Kelher, Marguerite R., Nuss, Rachelle, Cole, Laura, Liang, Xiayuan, Silliman, Christopher C.

“…Background Acute chest syndrome (ACS) in sickle cell disease is associated with elevation of secretory phospholipase A2 (sPLA2). We hypothesize that sPLA2…”
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Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils by Silliman, Christopher C, Kelher, Marguerite R, Gamboni-Robertson, Fabia, Hamiel, Christine, England, Kelly M, Dinarello, Charles A, Wyman, Travis H, Khan, Samina Y, McLaughlin, Nathan J D, Bercovitz, Rachel S, Banerjee, Anirban

“…Neutrophils (PMNs) are a vital part of host defense and are the principal leukocyte in innate immunity. Interleukin (IL)-18 is a proinflammatory cytokine with…”
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Platelet-Activating Factor-Mediated Endosome Formation Causes Membrane Translocation of p67phox and p40phox That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils by McLaughlin, Nathan J. D, Banerjee, Anirban, Khan, Samina Y, Lieber, Janet L, Kelher, Marguerite R, Gamboni-Robertson, Fabia, Sheppard, Forest R, Moore, Ernest E, Mierau, Gary W, Elzi, David J, Silliman, Christopher C

“…Neutrophils (polymorphonuclear leukocytes, PMNs) are vital to innate immunity and receive proinflammatory signals that activate G protein-coupled receptors…”
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LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47 phox phosphorylation and membrane translocation in neutrophils by Kelher, Marguerite R, McLaughlin, Nathan J D, Banerjee, Anirban, Elzi, David J, Gamboni, Fabia, Khan, Samina Y, Meng, Xianzhong, Mitra, Sanchayita, Silliman, Christopher C

“…Abstract Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury…”
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Supernatants and Lipids from Stored RBCs Activate Pulmonary Microvascular Endothelium through the BLT2 Receptor and Protein Kinase C Activation by Silliman, Christopher C., Kelher, Marguerite R., Khan, Samina Y., West, F. Bernadette, McLaughlin, Nathan J. D., Elzi, David J., England, Kelly J., Bjornsen, Jason, Kuldanek, Susan A., Banerjee, Anirban

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Leukotriene b4 and its metabolites prime the neutrophil oxidase and induce proinflammatory activation of human pulmonary microvascular endothelial cells by Eun, John C, Moore, Ernest E, Banerjee, Anirban, Kelher, Marguerite R, Khan, Samina Y, Elzi, David J, McLaughlin, Nathan J D, Silliman, Christopher C

“…Leukotrienes are proinflammatory lipid mediators, derived from arachidonic acid via 5-lipoxygenase (5-LO). Leukotriene B4 (LTB4) is an effective…”
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Platelet-Activating Factor-Mediated Endosome Formation Causes Membrane Translocation of p67 phox and p40 phox That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils by McLaughlin, Nathan J. D., Banerjee, Anirban, Khan, Samina Y., Lieber, Janet L., Kelher, Marguerite R., Gamboni-Robertson, Fabia, Sheppard, Forest R., Moore, Ernest E., Mierau, Gary W., Elzi, David J., Silliman, Christopher C.

“…Abstract Neutrophils (polymorphonuclear leukocytes, PMNs) are vital to innate immunity and receive proinflammatory signals that activate G protein-coupled…”
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Platelet-Activating Factor-Mediated Endosome Formation Causes Membrane Translocation of p67phox and p40phox That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils1 by McLaughlin, Nathan J. D., Banerjee, Anirban, Khan, Samina Y., Lieber, Janet L., Kelher, Marguerite R., Gamboni-Robertson, Fabia, Sheppard, Forest R., Moore, Ernest E., Mierau, Gary W., Elzi, David J., Silliman, Christopher C.

“…Neutrophils (polymorphonuclear leukocytes, PMNs) are vital to innate immunity and receive proinflammatory signals that activate G protein-coupled receptors…”
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Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs by Khan, Samina Y, McLaughlin, Nathan J D, Kelher, Marguerite R, Eckels, Phillip, Gamboni-Robertson, Fabia, Banerjee, Anirban, Silliman, Christopher C

“…Lyso-PCs (lysophosphatidylcholines) are a mixture of lipids that accumulate during storage of cellular blood components, have been implicated in TRALI…”
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Hydroxyurea Treatment of Children with Sickle Cell Disease Inhibits RBC Membrane Degradation by Secretory Phospholipase a2 by Ball, James B, Khan, Samina Y, McLaughlin, Nathan JD, Nuss, Rachelle, Cole, Laura, Silliman, Christopher C.

“…Background: Secretory phospholipase A2 is an enzyme that is elevated in SCD patients with acute chest syndrome (ACS) and vaso-occlusive pain crisis (VOC) and…”
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Platelet-Activating Factor-Mediated Endosome Formation Causes Membrane Translocation of p67 super(phox) and p40 super(phox) That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils by McLaughlin, Nathan JD, Banerjee, Anirban, Khan, Samina Y, Lieber, Janet L, Kelher, Marguerite R, Gamboni-Robertson, Fabia, Sheppard, est R, Moore, Ernest E, Mierau, Gary W, Elzi, David J, Silliman, Christopher C

“…Neutrophils (polymorphonuclear leukocytes, PMNs) are vital to innate immunity and receive proinflammatory signals that activate G protein-coupled receptors…”
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