Search Results - "McLaughlin, L"
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1
Selective fragmentation and the management of fish movement across anthropogenic barriers
Published in Ecological applications (01-12-2018)“…Disruption of movement patterns due to alterations in habitat connectivity is a pervasive effect of humans on animal populations. In many terrestrial and…”
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2
Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products
Published in Journal of natural products (Washington, D.C.) (01-07-2008)“…Extracts of paw paw (Asimina triloba, Annonaceae) are among the most potent of the 3500 species of higher plants screened for bioactive compounds in our…”
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3
Genome flux and stasis in a five millennium transect of European prehistory
Published in Nature communications (21-10-2014)“…The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human…”
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4
Droplet Volume Variability and Impact on Digital PCR Copy Number Concentration Measurements
Published in Analytical chemistry (Washington) (19-03-2019)“…Digital polymerase chain reaction (dPCR) is increasingly being adopted by reference material producers and metrology institutes for value assignment, and for…”
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5
Realizing ecosystem services: wetland hydrologic function along a gradient of ecosystem condition
Published in Ecological applications (01-10-2013)“…Wetlands provide numerous ecosystem services, from habitat provision to pollutant removal, floodwater storage, and microclimate regulation. Delivery of…”
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6
Do geographically isolated wetlands influence landscape functions?
Published in Proceedings of the National Academy of Sciences - PNAS (23-02-2016)“…Geographically isolated wetlands (GIWs), those surrounded by uplands, exchange materials, energy, and organisms with other elements in hydrological and habitat…”
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7
WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial–mesenchymal transition
Published in The Journal of biological chemistry (05-04-2019)“…Besides intrinsic changes, malignant cells also release soluble signals that reshape their microenvironment. Among these signals is WNT1-inducible signaling…”
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8
Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs
Published in Scientific reports (19-10-2020)“…Human disease pathophysiology commonly involves metabolic disruption at both the cellular and subcellular levels. Isolated mitochondria are a powerful model…”
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SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
Published in Science translational medicine (07-12-2022)“…Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet…”
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10
Microtopography is a fundamental organizing structure of vegetation and soil chemistry in black ash wetlands
Published in Biogeosciences (21-02-2020)“…All wetland ecosystems are controlled by water table and soil saturation dynamics, so any local-scale deviation in soil elevation and thus water table position…”
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11
SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma
Published in Oncogene (02-06-2016)“…Cancer stem cells (CSCs) are a promising target for cancer therapy, particularly for metastatic lung cancers, but how CSCs are regulated is largely unknown. We…”
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12
Insular Celtic population structure and genomic footprints of migration
Published in PLoS genetics (25-01-2018)“…Previous studies of the genetic landscape of Ireland have suggested homogeneity, with population substructure undetectable using single-marker methods. Here we…”
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13
Development of Targeted Alpha Particle Therapy for Solid Tumors
Published in Molecules (Basel, Switzerland) (26-11-2019)“…Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-particles (cytotoxic payload) to tumors by chelation to monoclonal…”
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14
Geographically isolated wetlands are part of the hydrological landscape
Published in Hydrological processes (01-01-2016)Get full text
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15
Genomic signals of migration and continuity in Britain before the Anglo-Saxons
Published in Nature communications (19-01-2016)“…The purported migrations that have formed the peoples of Britain have been the focus of generations of scholarly controversy. However, this has not benefited…”
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16
Determining performance characteristics of an NGS-based HLA typing method for clinical applications
Published in HLA (01-03-2016)“…This study presents performance specifications of an in‐house developed human leukocyte antigen (HLA) typing assay using next‐generation sequencing (NGS) on…”
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Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study
Published in Lancet neurology (01-03-2012)“…Summary Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of upper and lower motor neurons, associated with…”
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18
Dutch population structure across space, time and GWAS design
Published in Nature communications (11-09-2020)“…Previous genetic studies have identified local population structure within the Netherlands; however their resolution is limited by use of unlinked markers and…”
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Pattern and structure of microtopography implies autogenic origins in forested wetlands
Published in Hydrology and earth system sciences (16-12-2019)“…Wetland microtopography is a visually striking feature, but also critically influences biogeochemical processes at both the scale of its observation (10−2–102…”
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20
Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis
Published in European journal of neurology (01-05-2023)“…Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder associated with considerable clinical disability. Symptoms…”
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