Search Results - "McLaughlin, Douglas C."

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic by Zhang, Xuqing, Luo, Mengyao, Dastagir, Shamael R., Nixon, Mellissa, Khamhoung, Annie, Schmidt, Andrea, Lee, Albert, Subbiah, Naren, McLaughlin, Douglas C., Moore, Christopher L., Gribble, Mary, Bayhi, Nicholas, Amin, Viral, Pepi, Ryan, Pawar, Sneha, Lyford, Timothy J., Soman, Vikram, Mellen, Jennifer, Carpenter, Christopher L., Turka, Laurence A., Wickham, Thomas J., Chen, Tiffany F.

“…Checkpoint inhibitors and T-cell therapies have highlighted the critical role of T cells in anti-cancer immunity. However, limitations associated with these…”
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Structures of Adnectin/Protein Complexes Reveal an Expanded Binding Footprint by Ramamurthy, Vidhyashankar, Krystek, Stanley R., Bush, Alexander, Wei, Anzhi, Emanuel, Stuart L., Das Gupta, Ruchira, Janjua, Ahsen, Cheng, Lin, Murdock, Melissa, Abramczyk, Bozena, Cohen, Daniel, Lin, Zheng, Morin, Paul, Davis, Jonathan H., Dabritz, Michael, McLaughlin, Douglas C., Russo, Katie A., Chao, Ginger, Wright, Martin C., Jenny, Victoria A., Engle, Linda J., Furfine, Eric, Sheriff, Steven

“…Adnectins are targeted biologics derived from the tenth type III domain of human fibronectin (10Fn3), a member of the immunoglobulin superfamily…”
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Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15 by McArdel, Shannon L., Dugast, Anne-Sophie, Hoover, Maegan E., Bollampalli, Arjun, Hong, Enping, Castano, Zafira, Leonard, Shannon Curtis, Pawar, Sneha, Mellen, Jennifer, Muriuki, Kelvin, McLaughlin, Douglas C., Bayhi, Nicholas, Carpenter, Christopher L., Turka, Laurence A., Wickham, Thomas J., Elloul, Sivan

“…Recombinant agonists that activate co-stimulatory and cytokine receptors have shown limited clinical anticancer utility, potentially due to narrow therapeutic…”
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Abstract 3256: RTX-IL-12, an allogeneic red cell therapeutic expressing IL-12, exhibits potent in vitro and in vivo activity and favorable safety profile by Dugast, Anne-Sophie, Hong, Enping, Hoover, Maegan, Bollampalli, Arjun, McLaughlin, Douglas C., Bhate, Omkar, Lyford, Timothy J., Nissen, Torben Straight, Carpenter, Christopher L., Wickham, Thomas J., Elloul, Sivan

“…Recombinant IL-12 is a potent cytokine that has held significant promise as an immunotherapeutic. In preclinical studies, recombinant IL-12 has impressive…”
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Abstract 3272: RTX-212, an allogeneic red cell therapeutic expressing 4-1BBL and IL-15TP, exhibits potent in vitro and in vivo activity and a favorable safety profile by Dugast, Anne-Sophie, McArdel, Shannon, Hoover, Maegan, Hong, Enping, Leonard, Shannon Curtis, Bollampalli, Arjun, McLaughlin, Douglas C., Mellen, Jennifer, Nissen, Torben Straight, Carpenter, Christopher L., Wickham, Thomas J., Elloul, Sivan

“…Recombinant agonists that activate co-stimulatory and cytokine receptors have shown limited clinical activity perhaps due to 1) toxicity; 2) a need for…”
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Abstract 3260: Engineered red-cell therapeutics (RCT) as artificial antigen presenting cells promote in vivo expansion and anti-tumor activity of antigen specific T cells by Zhang, Xuqing, Dastagir, Shamael R., Subbiah, Naren, Luo, Mengyao, Soman, Vikram, Pawar, Sneha, McLaughlin, Douglas C., Bayhi, Nicholas, Amin, Viral, Nissen, Torben Straight, Carpenter, Christopher L., Wickham, Thomas J., Chen, Tiffany F.

“…T cell-based therapies have demonstrated efficacy in a small subset of cancers; however, they have the potential to proliferate uncontrollably and…”
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Abstract B062: Enabling the rapid generation of allogeneic artificial antigen presenting cell (aAPC) Red Cell Therapeutics with a loadable MHC system by Moore, Christopher L, Pawar, Sneha, Nixon, Mellissa, Lyford, Timothy J, McLaughlin, Douglas C, Dastagir, Shamael R, Bracha, Abigail, Melancon, Lori, Carpenter, Christopher L, Wickham, Thomas J, Chen, Tiffany F

“…Next generation sequencing technologies, coupled with personal neoantigen identification approaches, have significantly improved the capability to develop…”
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