Search Results - "McLaren, D B"

Redefining precision radiotherapy through liquid biopsy by McLaren, D. B., Aitman, T. J.

“…Precision radiotherapy refers to the ability to deliver radiation doses with sub-millimetre accuracy. It does not however consider individual variation in…”
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Clinically relevant fatigue in men with hormone-sensitive prostate cancer on long-term androgen deprivation therapy by Storey, D.J., McLaren, D.B., Atkinson, M.A., Butcher, I., Frew, L.C., Smyth, J.F., Sharpe, M.

“…The purpose of the study was to determine the prevalence and associations of clinically relevant fatigue (CRF) in men with biochemically controlled prostate…”
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Clinically relevant fatigue in recurrence-free prostate cancer survivors by Storey, D.J., McLaren, D.B., Atkinson, M.A., Butcher, I., Liggatt, S., O’Dea, R., Smyth, J.F., Sharpe, M.

“…Little is known about the prevalence and associations of clinically relevant fatigue (CRF) in recurrence-free prostate cancer survivors. Four hundred and…”
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Watchful waiting or watchful progression? Prostate specific antigen doubling times and clinical behavior in patients with early untreated prostate carcinoma by MCLAREN, D. B, MCKENZIE, M, DUNCAN, G, PICKLES, T

“…Prostate specific antigen doubling time (PSAdt) is a dynamic model of prostate tumor biology. It predicts aggressive disease and subsequent clinical recurrence…”
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Defining Biochemical Cure After Low Dose Rate Prostate Brachytherapy: External Validation of 4-year Prostate-specific Antigen Nadir as a Predictor of 10- and 15-year Disease-free Survival by Noble, D.J., Doyle, E., Tramonti, G., Law, A.B., Sundaramurthy, A., Brush, J.P., Keanie, J., Wood, C., Drewell, P., Keough, W., McLaren, D.B.

“…To externally validate a proposed biochemical definition of cure following low dose rate (LDR) brachytherapy for prostate cancer – 4-year post-implant…”
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Acute Toxicity of Hypofractionated and Conventionally Fractionated (Chemo)Radiotherapy Regimens for Bladder Cancer: An Exploratory Analysis from the RAIDER Trial by Huddart, R., Hafeez, S., Omar, A., Alonzi, R., Birtle, A., Cheung, K.C., Choudhury, A., Foroudi, F., Gribble, H., Henry, A., Hilman, S., Hindson, B., Lewis, R., Muthukumar, D., McLaren, D.B., McNair, H., Nikapota, A., Olorunfemi, A., Parikh, O., Philipps, L., Rimmer, Y., Syndikus, I., Tolentino, A., Varughese, M., Vassallo-Bonner, C., Webster, A., Griffin, C., Hall, E.

“…Adding concurrent (chemo)therapy to radiotherapy improves outcomes for muscle-invasive bladder cancer patients. A recent meta-analysis showed superior invasive…”
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Non-surgical treatment for early prostate cancer by Law, A B, McLaren, D B

“…Prostate cancer incidence is rising due to the ageing population and increased public and doctor awareness. The role of screening is still not clear due to the…”
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Stereotactic Body Radiotherapy by Dahele, M, McLaren, D.B

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Testicular Sex Cord–Stromal Tumours: The Edinburgh Experience 1988–2002, and a Review of the Literature by Conkey, D.S., Howard, G.C.W., Grigor, K.M., McLaren, D.B., Kerr, G.R.

“…Sex cord–stromal tumours of the testis are uncommon tumours, accounting for around 5% of testicular neoplasms. Treatment is primarily surgical, with no…”
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Clinically relevant fatigue in men with hormone-sensitive prostate cancer on long-term androgen deprivation therapy by Storey, DJ, McLaren, DB, Atkinson, MA, Butcher, I, Frew, LC, Smyth, JF, Sharpe, M

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Radical Radiotherapy and Salvage Cystectomy as the Primary Management of Transitional Cell Carcinoma of the Bladder. Results Following the Introduction of a CT Planning Technique by Borgaonkar, S., Jain, A., Bollina, P., Mclaren, D.B., Tulloch, D., Kerr, G.R., Howard, G.C.W.

“…The objective of this study was to review the results of our policy of primary radiotherapy (RT) and salvage cystectomy for transitional carcinoma (TCC) of the…”
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The comet assay in clinical practice by Olive, P L, Durand, R E, Jackson, S M, Le Riche, J C, Luo, C, Ma, R, McLaren, D B, Aquino-Parsons, C, Thomson, T A, Trotter, T

“…The comet assay is a single-cell gel electrophoresis technique that measures DNA damage in individual cells. Since radiation produces 3-4 times more DNA damage…”
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A long and winding road: the role of chemotherapy for hormone-refractory prostate cancer by Higgins, G S, Stewart, G D, McNeill, S A, McLaren, D B

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The prevalence and significance of cyst-like changes at the cruciate ligament attachments in the knee by MCLAREN, D. B, BUCKWATER, K. A, VAHEY, T. N

“…Approximately 1% of the total population referred for magnetic resonance imaging (MRI) of the knee at our facility have cystic changes at or near the…”
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Neoadjuvant Chemotherapy in Transitional-cell Carcinoma of the Bladder by McLaren, D.B.

“…Neoadjuvant chemotherapy in transitional-cell carcinoma of the bladder (TCC) improves survival. This is one of the most important developments in the…”
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Hypofractionated radiotherapy for muscle invasive bladder cancer in the elderly by McLaren, Duncan B., Morrey, David, Mason, Malcolm D.

“…Background and purpose: We have retrospectively investigated a hypofractionated regimen in a cohort of 65 elderly patients (median age 78 years), designed to…”
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The Management and Outcome of Patients with Germ-cell Tumours Treated in the Edinburgh Cancer Centre Between 1988 and 2002 by Howard, G.C.W., Conkey, D.S., Peoples, S., McLaren, D.B., Hargreave, T.B., Tulloch, D.N., Walker, W., Kerr, G.R.

“…The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15…”
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Impact of nicotinamide on human tumour hypoxic fraction measured using the comet assay by McLaren, Duncan B., Pickles, Tom, Thomson, Tom, Olive, Peggy L.

“…Background and purpose: Nicotinamide has been shown to reduce hypoxia in experimental tumours, but there are no data that measure the hypoxic fraction at the…”
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The Importance of Prostate-specific Antigen (PSA) Nadir and Early Identification of PSA Relapse after 10 Years of Prostate Iodine 125 Seed Brachytherapy in Edinburgh by McLaren, D B, Kerr, G, Law, A B, Brush, J P, Keanie, J, Malik, J, Keough, W, Ronaldson, T, Lee, J, Kehoe, T

“…To analyse our 5 and 10 year prostate brachytherapy outcome data and to assess the impact of PSA nadir on relapse free survival and whether an alternative…”
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Primary chemotherapy and radiation therapy for locally advanced carcinoma of the breast: 15 years of experience by McLaren, D.B., Morrey, D., Keen, C.W., Webster, D.J.T., Barrett-Lee, P.J.

“…The data on 91 patients (aged 30–78 years) with inoperable locally advanced breast cancer treated by primary chemotherapy and radiation therapy from 1980 to…”
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