Search Results - "McLaren, Alex"

Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work by Schwarz, Edward M., McLaren, Alex C., Sculco, Thomas P., Brause, Barry, Bostrom, Mathias, Kates, Stephen L., Parvizi, Javad, Alt, Volker, Arnold, William V., Carli, Alberto, Chen, Antonia F., Choe, Hyonmin, Coraça‐Huber, Débora C., Cross, Michael, Ghert, Michelle, Hickok, Noreen, Jennings, Jessica Amber, Joshi, Manjari, Metsemakers, Willem‐Jan, Ninomiya, Mark, Nishitani, Kohei, Oh, Irvin, Padgett, Douglas, Ricciardi, Benjamin, Saeed, Kordo, Sendi, Parham, Springer, Bryan, Stoodley, Paul, Wenke, Joseph C.

“…Antibiotic‐loaded bone cement (ALBC) is broadly used to treat orthopaedic infections based on the rationale that high‐dose local delivery is essential to…”
Get full text

Extended Release of Bupivacaine from Temperature-Responsive PNDJ Hydrogels Improves Postoperative Weight-Bearing in Rabbits Following Knee Surgery by Overstreet, Derek J, Zdrale, Gabriel, McLaren, Alex C

“…Effective treatment of postoperative pain lasting for multiple days without opioids is an important clinical need. We previously reported analgesia lasting up…”
Get full text

A virtual reality simulator for orthopedic basic skills: A design and validation study by Vankipuram, Mithra, Kahol, Kanav, McLaren, Alex, Panchanathan, Sethuraman

“…Orthopedic drilling as a skill demands high levels of dexterity and expertise from the surgeon. It is a basic skill that is required in many orthopedic…”
Get full text

Liposomal Formulation Decreases Toxicity of Amphotericin B In Vitro and In Vivo by Roberts, Justin, Bingham, Josh, McLaren, Alex C., McLemore, Ryan

“…Background Liposomal amphotericin B is locally delivered to treat fungal orthopaedic infections but little is known about local tissue toxicity, if any, that…”
Get full text

Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections by McLaren, Alex C

“…Acrylic bone cement has considerable laboratory and clinical data validating it as a delivery material for depot administration of antibiotics. However, an…”
Get more information

Amphotericin B Delivery From Bone Cement Increases With Porosity but Strength Decreases by Kweon, Chris, McLaren, Alex C., Leon, Christine, McLemore, Ryan

“…Background Amphotericin B is a highly hydrophobic antifungal used for orthopaedic infections. There is disagreement about whether amphotericin B is released…”
Get full text

Local antimicrobial delivery from temperature-responsive hydrogels reduces incidence of intra-abdominal infection in rats by Heffernan, John M., McLaren, Alex C., Overstreet, Derek J.

“…The objective of this study was to evaluate local antimicrobial delivery from temperature-responsive hydrogels for preventing infection in a rat model of…”
Get full text

AAOS Systematic Review: Management of Surgical Site Infections by Chen, Antonia F., McLaren, Alex C.

Get full text

Amphotericin B Is Cytotoxic at Locally Delivered Concentrations by Harmsen, Samuel, McLaren, Alex C., Pauken, Christine, McLemore, Ryan

“…Background Orthopaedic fungal infections are commonly treated with systemic amphotericin, which has a narrow therapeutic index and is associated with systemic…”
Get full text

Liposomal Formulation Increases Local Delivery of Amphotericin from Bone Cement: A Pilot Study by Cunningham, Brian, McLaren, Alex C., Pauken, Christine, McLemore, Ryan

“…Background Amphotericin is a highly toxic hydrophobic antifungal. Delivery of amphotericin from antifungal-loaded bone cement (ALBC) is much lower than would…”
Get full text

Biophysical separation of Staphylococcus epidermidis strains based on antibiotic resistance by Jones, Paul V, Huey, Shannon, Davis, Paige, Yanashima, Ryan, McLemore, Ryan, McLaren, Alex, Hayes, Mark A

“…Electrophoretic and dielectrophoretic approaches to separations can provide unique capabilities. In the past, capillary and microchip-based approaches to…”
Get more information

Extended Release of Bupivacaine from Temperature-responsive Hydrogels Provides Multi-day Analgesia for Postoperative Pain by Heffernan, John M, McLaren, Alex C, Glass, Christopher M, Overstreet, Derek J

“…A local anesthetic that provides analgesia lasting at least three days could significantly improve postoperative pain management. This study evaluated the…”
Get full text

Voriconazole Is Delivered From Antifungal-Loaded Bone Cement by Miller, Ryan B., McLaren, Alex C., Pauken, Christine, Clarke, Henry D., McLemore, Ryan

“…Background Local delivery of antifungals is an important modality in managing orthopaedic fungal infection. Voriconazole is a powder antifungal suitable for…”
Get full text

In vivo evaluation of temperature‐responsive antimicrobial‐loaded PNIPAAm hydrogels for prevention of surgical site infection by Heffernan, John M., Overstreet, Derek J., Vernon, Brent L., McLemore, Ryan Y., Nagy, Tamas, Moore, Rex C., Badha, Vajra S., Childers, Erin P., Nguyen, Michael B., Gentry, Daniel D., Calara, Francis M., Saunders, W. Brian, Feltis, Tim, McLaren, Alex C.

“…Surgical site infections (SSIs) are a persistent clinical challenge. Local antimicrobial delivery may reduce the risk of SSI by increasing drug concentrations…”
Get full text

Bacterial toxins in musculoskeletal infections by Saeed, Kordo, Sendi, Parham, Arnold, William V., Bauer, Thomas W., Coraça‐Huber, Débora C., Chen, Antonia F., Choe, Hyonmin, Daiss, John L., Ghert, Michelle, Hickok, Noreen J., Nishitani, Kohei, Springer, Bryan D., Stoodley, Paul, Sculco, Thomas P., Brause, Barry D., Parvizi, Javad, McLaren, Alex C., Schwarz, Edward M.

“…Musculoskeletal infections (MSKIs) remain a major health burden in orthopaedics. Bacterial toxins are foundational to pathogenesis in MSKI, but poorly…”
Get full text

2018 International Consensus Meeting on Musculoskeletal Infection: Research Priorities from the General Assembly Questions by Schwarz, Edward M., Parvizi, Javad, Gehrke, Thorsten, Aiyer, Amiethab, Battenberg, Andrew, Brown, Scot A., Callaghan, John J., Citak, Mustafa, Egol, Kenneth, Garrigues, Grant E., Ghert, Michelle, Goswami, Karan, Green, Andrew, Hammound, Sommer, Kates, Stephen L., McLaren, Alex C., Mont, Michael A., Namdari, Surena, Obremskey, William T., O'Toole, Robert, Raikin, Steven, Restrepo, Camilo, Ricciardi, Benjamin, Saeed, Kordo, Sanchez‐Sotelo, Joaquin, Shohat, Noam, Tan, Timothy, Thirukumaran, Caroline P., Winters, Brian

“…ABSTRACT Musculoskeletal infections (MSKI) remain the bane of orthopedic surgery, and result in grievous illness and inordinate costs that threaten healthcare…”
Get full text

Corridor-diameter-dependent angular tolerance for safe transiliosacral screw placement: an anatomic study of 433 pelves by McLaren, D. Alex, Busel, Gennadiy A., Parikh, Harsh R., Only, Arthur, Patterson, Jason, Gaston, Brandon T., McLemore, Ryan, Cunningham, Brian

“…Background The purpose of this study was to determine the angular tolerance of the S1 and S2 segments to accommodate a transiliosacral screw across both…”
Get full text

Hand-mixed and Premixed Antibiotic-loaded Bone Cement Have Similar Homogeneity by McLaren, Alex C., Nugent, Matt, Economopoulos, Kostas, Kaul, Himanshu, Vernon, Brent L., McLemore, Ryan

“…Since low-dose antibiotic-loaded bone cement (ALBC) was approved by the FDA for second-stage reimplantation after infected arthroplasties in 2003, commercially…”
Get full text

2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections by Saeed, Kordo, McLaren, Alex C., Schwarz, Edward M., Antoci, Valentin, Arnold, William V., Chen, Antonia F., Clauss, Martin, Esteban, Jaime, Gant, Vanya, Hendershot, Edward, Hickok, Noreen, Higuera, Carlos A., Coraça‐Huber, Débora C., Choe, Hyonmin, Jennings, Jessica A., Joshi, Manjari, Li, William T., Noble, Philip C., Phillips, K. Scott, Pottinger, Paul S., Restrepo, Camilo, Rohde, Holger, Schaer, Thomas P., Shen, Hao, Smeltzer, Mark, Stoodley, Paul, Webb, Jason C. J., Witsø, Eivind

“…ABSTRACT Biofilm‐associated implant‐related bone and joint infections are clinically important due to the extensive morbidity, cost of care and socioeconomic…”
Get full text

Is aseptic loosening truly aseptic? by Nelson, Carl L, McLaren, Alex C, McLaren, Sandra G, Johnson, Jeffrey W, Smeltzer, Mark S

“…Surgeons who treat osteomyelitis or infected implants think that microorganisms can live on and around implanted biomaterials and necrotic bone without…”
Get more information