Search Results - "McLane, Laura M"

Characterization of T-bet and eomes in peripheral human immune cells by Knox, James J, Cosma, Gabriela L, Betts, Michael R, McLane, Laura M

“…The T-box transcription factors T-bet and Eomesodermin (Eomes) have been well defined as key drivers of immune cell development and cytolytic function. While…”
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Nuclear localization signals and human disease by McLane, Laura M., Corbett, Anita H.

“…In eukaryotic cells, the physical separation of the genetic material in the nucleus from the translation and signaling machinery in the cytoplasm by the…”
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CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer by McLane, Laura M, Abdel-Hakeem, Mohamed S, Wherry, E. John

“…Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are…”
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Expanding the Definition of the Classical Bipartite Nuclear Localization Signal by Lange, Allison, McLane, Laura M, Mills, Ryan E, Devine, Scott E, Corbett, Anita H

“…Nuclear localization signals (NLSs) are amino acid sequences that target cargo proteins into the nucleus. Rigorous characterization of NLS motifs is essential…”
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Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease by Buggert, Marcus, Nguyen, Son, McLane, Laura M, Steblyanko, Maria, Anikeeva, Nadia, Paquin-Proulx, Dominic, Del Rio Estrada, Perla M, Ablanedo-Terrazas, Yuria, Noyan, Kajsa, Reuter, Morgan A, Demers, Korey, Sandberg, Johan K, Eller, Michael A, Streeck, Hendrik, Jansson, Marianne, Nowak, Piotr, Sönnerborg, Anders, Canaday, David H, Naji, Ali, Wherry, E John, Robb, Merlin L, Deeks, Steven G, Reyes-Teran, Gustavo, Sykulev, Yuri, Karlsson, Annika C, Betts, Michael R

“…CD4+ T cells subsets have a wide range of important helper and regulatory functions in the immune system. Several studies have specifically suggested that…”
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Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion by Bengsch, Bertram, Johnson, Andy L., Kurachi, Makoto, Odorizzi, Pamela M., Pauken, Kristen E., Attanasio, John, Stelekati, Erietta, McLane, Laura M., Paley, Michael A., Delgoffe, Greg M., Wherry, E. John

“…Dynamic reprogramming of metabolism is essential for T cell effector function and memory formation. However, the regulation of metabolism in exhausted CD8+ T…”
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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision by Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C., Johnson, John, Staupe, Ryan P., Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S., Vella, Laura A., Baxter, Amy E., Wu, Jennifer E., Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R., Stelekati, Erietta, McLane, Laura M., Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L., Vahedi, Golnaz, Ji, Hongkai, Wherry, E. John

“…TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway…”
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Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells by McLane, Laura M., Ngiow, Shin Foong, Chen, Zeyu, Attanasio, John, Manne, Sasikanth, Ruthel, Gordon, Wu, Jennifer E., Staupe, Ryan P., Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Freedman, Bruce D., Betts, Michael R., Wherry, E. John

“…The transcription factors T-bet and Eomesodermin (Eomes) regulate CD8 T cell exhaustion through undefined mechanisms. Here, we show that the subcellular…”
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Differential localization of T-bet and Eomes in CD8 T cell memory populations by McLane, Laura M, Banerjee, Pinaki P, Cosma, Gabriela L, Makedonas, George, Wherry, E John, Orange, Jordan S, Betts, Michael R

“…In mice, two T-box transcription factors, T-box expressed in T cells (T-bet) and eomesodermin (Eomes), drive the differentiation of CD8 T cell lineages;…”
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Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155 by Stelekati, Erietta, Chen, Zeyu, Manne, Sasikanth, Kurachi, Makoto, Ali, Mohammed-Alkhatim, Lewy, Keith, Cai, Zhangying, Nzingha, Kito, McLane, Laura M., Hope, Jennifer L., Fike, Adam J., Katsikis, Peter D., Wherry, E. John

“…Persistent viral infections and tumors drive development of exhausted T (TEX) cells. In these settings, TEX cells establish an important host-pathogen or…”
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A genome-wide RNAi screen reveals that mRNA decapping restricts bunyaviral replication by limiting the pools of Dcp2-accessible targets for cap-snatching by Hopkins, Kaycie C, McLane, Laura M, Maqbool, Tariq, Panda, Debasis, Gordesky-Gold, Beth, Cherry, Sara

“…Bunyaviruses are an emerging group of medically important viruses, many of which are transmitted from insects to mammals. To identify host factors that impact…”
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Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function by Kurachi, Makoto, Kurachi, Junko, Chen, Zeyu, Johnson, John, Khan, Omar, Bengsch, Bertram, Stelekati, Erietta, Attanasio, John, McLane, Laura M, Tomura, Michio, Ueha, Satoshi, Wherry, E John

“…This protocol describes an optimized procedure for retroviral (RV) transduction of mouse T cells by enriching RV-susceptible activated CD8 + T cells through…”
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Corrigendum: Characterization of T-bet and Eomes in Peripheral Human Immune Cells by Knox, James J, Cosma, Gabriela L, Betts, Michael R, McLane, Laura M

“…[This corrects the article on p. 217 in vol. 5, PMID: 24860576.]…”
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Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus by McLane, Laura M, Pulliam, Kanika F, Devine, Scott E, Corbett, Anita H

“…Like its retroviral relatives, the long terminal repeat retrotransposon Ty1 in the yeast Saccharomyces cerevisiae must traverse a permanently intact nuclear…”
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Classical Nuclear Localization Signal Receptor, Importin-α, Is Required for Efficient Transition Through the G1/S Stage of the Cell Cycle in Saccharomyces cerevisiae by Pulliam, Kanika F, Fasken, Milo B, McLane, Laura M, Pulliam, John V, Corbett, Anita H

“…There is significant evidence linking nucleocytoplasmic transport to cell cycle control. The budding yeast, Saccharomyces cerevisiae, serves as an ideal model…”
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Analysis of a predicted nuclear localization signal: implications for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp160 by Brykailo, Melissa A, McLane, Laura M, Fridovich-Keil, Judith, Corbett, Anita H

“…Gene expression is controlled by RNA-binding proteins that modulate the synthesis, processing, transport and stability of various classes of RNA. Some…”
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Abstract 3597: SUV420H2-mediated regulation of collective invasion in triple-negative breast cancer by Whitt, Emily Campbell, McLane, Laura M., Vertino, Paula M.

“…Abstract Breast cancer is the second most common cancer in women and metastasis is the leading cause of breast cancer-related mortality. While the factors…”
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Modulation of the subcellular localization of T-bet and Eomes alters CD8 exhaustion during chronic LCMV infection by McLane, Laura M, Attanasio, John, Huang, Alexander C., Wherry, E. John

“…Abstract Following acute viral infection, effector CD8 T-cells (TE) differentiate into long-lived memory cells (TMEM) required for secondary viral clearance…”
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Bioenergetic insufficiencies due to metabolic alterations regulated by PD-1 are an early driver of CD8+ T cell exhaustion by Bengsch, Bertram, Johnson, Andy L., Kurachi, Makoto, Odorizzi, Pamela M, Pauken, Kristen E., Attanasio, John, Stelekati, Erietta, McLane, Laura M., Paley, Michael A., Delgoffe, Greg M., Wherry, E. John

“…Dynamic reprogramming of metabolism is essential for T cell effector function and memory formation. However, the regulation of metabolism in exhausted CD8 + T…”
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The Classical Nuclear Localization Signal Receptor, Importin-[alpha], Is Required for Efficient Transition Through the G^sub 1^/S Stage of the Cell Cycle in Saccharomyces cerevisiae by Pulliam, Kanika F, Fasken, Milo B, McLane, Laura M, Pulliam, John V, Corbett, Anita H

“…The classical NLS consists of a sequence of basic amino acids in a single cluster (monopartite) or two clusters separated by a nonconserved amino acid linker…”
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