Search Results - "McLanahan, Eva D."

Dietary Iodine Sufficiency and Moderate Insufficiency in the Lactating Mother and Nursing Infant: A Computational Perspective by Fisher, W, Wang, Jian, George, Nysia I, Gearhart, Jeffery M, McLanahan, Eva D

“…The Institute of Medicine recommends that lactating women ingest 290 μg iodide/d and a nursing infant, less than two years of age, 110 μg/d. The World Health…”
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The Use of PBPK Models to Inform Human Health Risk Assessment: Case Study on Perchlorate and Radioiodide Human Lifestage Models by McLanahan, Eva D., White, Paul, Flowers, Lynn, Schlosser, Paul M.

“…Physiologically‐based pharmacokinetic (PBPK) models are often submitted to or selected by agencies, such as the U.S. Environmental Protection Agency (U.S. EPA)…”
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Public health evaluation of PFAS exposures and breastfeeding: a systematic literature review by Hoadley, Lydia, Watters, Michelle, Rogers, Rachel, Siegmann Werner, Lora, Markiewicz, Karl V, Forrester, Tina, McLanahan, Eva D

“…Abstract Per- and polyfluoroalkyl substances (PFAS) are a class of man-made chemicals that are persistent in the environment. They can be transferred across…”
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Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology by Ruiz, Patricia, Emond, Claude, McLanahan, Eva D, Joshi-Barr, Shivanjali, Mumtaz, Moiz

“…Abstract Mixtures risk assessment needs an efficient integration of in vivo, in vitro, and in silico data with epidemiology and human studies data. This…”
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Incorporation of fetal and child PFOA dosimetry in the derivation of health-based toxicity values by Kieskamp, Kyra Kimberly, Worley, Rachel Rogers, McLanahan, Eva D., Verner, Marc-André

“…Multiple agencies have developed health-based toxicity values for exposure to perfluorooctanoic acid (PFOA). Although PFOA exposure occurs in utero and through…”
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Species extrapolation of life-stage physiologically-based pharmacokinetic (PBPK) models to investigate the developmental toxicology of ethanol using in vitro to in vivo (IVIVE) methods by Martin, Sheppard A, McLanahan, Eva D, Bushnell, Philip J, Hunter, 3rd, E Sidney, El-Masri, Hisham

“…To provide useful alternatives to in vivo animal studies, in vitro assays for dose-response assessments of xenobiotic chemicals must use concentrations in…”
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Physiologically based pharmacokinetic model use in risk assessment--Why being published is not enough by McLanahan, Eva D, El-Masri, Hisham A, Sweeney, Lisa M, Kopylev, Leonid Y, Clewell, Harvey J, Wambaugh, John F, Schlosser, P M

“…A panel of experts in physiologically based pharmacokinetic (PBPK) modeling and relevant quantitative methods was convened to describe and discuss model…”
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Evaluation of iodide deficiency in the lactating rat and pup using a biologically based dose-response model by Fisher, Jeffrey W, Li, Shuang, Crofton, Kevin, Zoeller, R Thomas, McLanahan, Eva D, Lumen, Annie, Gilbert, Mary E

“…A biologically based dose-response (BBDR) model for the hypothalamic-pituitary thyroid (HPT) axis in the lactating rat and nursing pup was developed to…”
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Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk by Lehmann, Geniece M., Verner, Marc-André, Luukinen, Bryan, Henning, Cara, Assimon, Sue Anne, LaKind, Judy S., McLanahan, Eva D., Phillips, Linda J., Davis, Matthew H., Powers, Christina M., Hines, Erin P., Haddad, Sami, Longnecker, Matthew P., Poulsen, Michael T., Farrer, David G., Marchitti, Satori A., Tan, Yu-Mei, Swartout, Jeffrey C., Sagiv, Sharon K., Welsh, Clement, Campbell, Jerry L., Foster, Warren G., Yang, Raymond S. H., Fenton, Suzanne E., Tornero-Velez, Rogelio, Francis, Bettina M., Barnett, John B., El-Masri, Hisham A., Simmons, Jane Ellen

“…Abstract Lipophilic persistent environmental chemicals (LPECs) have the potential to accumulate within a woman's body lipids over the course of many years…”
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A Biologically Based Dose-Response Model for Dietary Iodide and the Hypothalamic-Pituitary-Thyroid Axis in the Adult Rat: Evaluation of Iodide Deficiency by McLanahan, Eva D., Andersen, Melvin E., Fisher, Jeffrey W.

“…A biologically based dose-response (BBDR) model was developed for dietary iodide and the hypothalamic-pituitary-thyroid (HPT) axis in adult rats. This BBDR-HPT…”
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Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T₄ and TSH by McLanahan, Eva D., Andersen, Melvin E., Campbell, Jerry L., Fisher, Jeffrey W.

“…Background: Perchlorate (ClO₄⁻) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. ClO₄⁻ competitively…”
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Development of multi-route physiologically-based pharmacokinetic models for ethanol in the adult, pregnant, and neonatal rat by Martin, Sheppard A., McLanahan, Eva D., El-Masri, Hisham, LeFew, William R., Bushnell, Philip J., Boyes, William K., Choi, Kyoungju, Clewell, Harvey J., Campbell, Jerry L.

“…Biofuel blends of 10% ethanol (EtOH) and gasoline are common in the USA, and higher EtOH concentrations are being considered (15-85%). Currently, no…”
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Use of novel inhalation kinetic studies to refine physiologically-based pharmacokinetic models for ethanol in non-pregnant and pregnant rats by Martin, Sheppard A., Oshiro, Wendy M., Evansky, Paul A., Degn, Laura L., Ledbetter, Allen D., Ford, Jermaine, Todd Krantz, Q., LeFew, William R., Beasley, Tracey E., El-Masri, Hisham, McLanahan, Eva D., Boyes, William K., Bushnell, Philip J.

“…Abstract Ethanol (EtOH) exposure induces a variety of concentration-dependent neurological and developmental effects in the rat. Physiologically-based…”
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Low-Dose Effects of Ammonium Perchlorate on the Hypothalamic-Pituitary-Thyroid Axis of Adult Male Rats Pretreated with PCB126 by McLanahan, Eva D., Campbell, Jerry L., Ferguson, Duncan C., Harmon, Barry, Hedge, Joan M., Crofton, Kevin M., Mattie, David R., Braverman, Lewis, Keys, Deborah A., Mumtaz, Moiz, Fisher, Jeffrey W.

“…The objective of this research was to characterize the disturbances in the hypothalamic-pituitary-thyroid (HPT) axis resulting from exposure to a binary…”
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Erratum to: "Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology" by Ruiz, Patricia, Emond, Claude, McLanahan, Eva D, Joshi-Barr, Shivanjali, Mumtaz, Moiz

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Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T 4 and TSH by McLanahan, Eva D., Andersen, Melvin E., Campbell, Jerry L., Fisher, Jeffrey W.

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Dietary Iodine Sufficiency and Moderate Insufficiency in the Lactating Mother and Nursing Infant: A Computational Perspective: e0149300 by Fisher, W, Wang, Jian, George, Nysia I, Gearhart, Jeffery M, McLanahan, Eva D

“…The Institute of Medicine recommends that lactating women ingest 290 Mg iodide/d and a nursing infant, less than two years of age, 110 Mg/d. The World Health…”
Get full text

Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total Tsub 4 and TSH by McLanahan, Eva D, Andersen, Melvin E, Campbell, Jerry L, Fisher, Jeffrey W

“…BACKGROUND: Perchlorate (ClO4(-)) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. ClO4(-)…”
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Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in Rat serum total [T.sub.4] and TSH by McLanahan, Eva D, Andersen, Melvin E, Campbell, Jr., Jerry L, Fisher, Jeffrey W

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Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T^sub 4^ and TSH by McLanahan, Eva D, Andersen, Melvin E, Campbell, Jerry L, Fisher, Jeffrey W

“…Perchlorate (ClO4(-)) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. ClO4(-) competitively inhibits…”
Get full text