Search Results - "McLachlan, Michael J"

An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents by Quraishi, Imran H, Stern, Shani, Mangan, Kile P, Zhang, Yalan, Ali, Syed R, Mercier, Michael R, Marchetto, Maria C, McLachlan, Michael J, Jones, Eugenia M, Gage, Fred H, Kaczmarek, Leonard K

“…Mutations in the KCNT1 (Slack, KNa1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. Expression in heterologous systems has…”
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Further improvement of phosphite dehydrogenase thermostability by saturation mutagenesis by McLachlan, Michael J, Johannes, Tyler W, Zhao, Huimin

“…Phosphite dehydrogenase represents a new enzymatic system for regenerating reduced nicotinamide cofactors for industrial biocatalysis. We previously engineered…”
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STAT5b Is Required for GH-Induced Liver Igf-I Gene Expression by Davey, Helen W, Xie, Tao, McLachlan, Michael J, Wilkins, Richard J, Waxman, David J, Grattan, David R

“…Although the increased expression of Igf-I in liver in response to GH is well characterized, the intracellular signaling pathways that mediate this effect have…”
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An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack K Na Currents by Quraishi, Imran H, Stern, Shani, Mangan, Kile P, Zhang, Yalan, Ali, Syed R, Mercier, Michael R, Marchetto, Maria C, McLachlan, Michael J, Jones, Eugenia M, Gage, Fred H, Kaczmarek, Leonard K

“…Mutations in the KCNT1 (Slack, K 1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. Expression in heterologous systems has…”
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Feedback Regulation of PRL Secretion Is Mediated by the Transcription Factor, Signal Transducer, and Activator of Transcription 5b by Grattan, David R, Xu, Junjie, McLachlan, Michael J, Kokay, Ilona C, Bunn, Stephen J, Hovey, Russell C, Davey, Helen W

“…PRL secretion from the anterior pituitary gland is inhibited by dopamine produced in the tuberoinfundibular dopamine neurons of the hypothalamus. The activity…”
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Orthogonal control of endogenous gene expression in mammalian cells using synthetic ligands by Liang, Jing, McLachlan, Michael J., Zhao, Huimin

“…Gene switches have wide utility in synthetic biology, gene therapy, and developmental biology, and multiple orthogonal gene switches are needed to construct…”
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A new fluorescence complementation biosensor for detection of estrogenic compounds by McLachlan, Michael J., Katzenellenbogen, John A., Zhao, Huimin

“…Estrogenic compounds are an important class of hormonal substances that can be found as environmental contaminants, with sources including pharmaceuticals,…”
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Directed Evolution of Orthogonal Ligand Specificity in a Single Scaffold by McLachlan, Michael J, Chockalingam, Karuppiah, Lai, Ka Chun, Zhao, Huimin

“…Two highly sensitive ligand–receptor pairs created from a single protein scaffold were fully orthogonal both to the native ligand–receptor pair and to one…”
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Elevated Basal Expression of Liver Peroxisomal β-Oxidation Enzymes and CYP4A Microsomal Fatty Acid ω-Hydroxylase in STAT5b−/− Mice: Cross-Talk in Vivo between Peroxisome Proliferator-Activated Receptor and Signal Transducer and Activator of Transcription Signaling Pathways by Zhou, Yuan-Chun, Davey, Helen W., McLachlan, Michael J., Xie, Tao, Waxman, David J.

“…Long-term treatment of rodents with peroxisome proliferator chemicals, a group of structurally diverse nongenotoxic carcinogens, leads to liver cancer in a…”
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STAT5b-deficient Mice Are Growth Hormone Pulse-resistant by Davey, Helen W., Park, Soo-Hee, Grattan, David R., McLachlan, Michael J., Waxman, David J.

“…The signal transducer and transcriptional activator STAT5b is required to maintain the adult male pattern of liver gene expression and whole body pubertal…”
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Directed Enzyme Evolution and High‐Throughput Screening by McLachlan, Michael J, Sullivan, Ryan P, Zhao, Huimin

“…This chapter contains sections titled: Introduction Directed Evolution Library Creation Strategies Directed Evolution Library Screening/Selection Methods…”
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STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression by Davey, H W, Park, S H, Grattan, D R, McLachlan, M J, Waxman, D J

“…The signal transducer and transcriptional activator STAT5b is required to maintain the adult male pattern of liver gene expression and whole body pubertal…”
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Directed Evolution of Orthogonal Ligand Specificity in a Single Scaffold by McLachlan, Michael J., Chockalingam, Karuppiah, Lai, Ka Chun, Zhao, Huimin

“…Zwei hochempfindliche Ligand‐Rezeptor‐Paare, die auf einem einzigen Proteingerüst beruhen, sind zum nativen Ligand‐Rezeptor‐Paar und zueinander vollständig…”
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Directed Evolution of Orthogonal Ligand Specificity in a Single Scaffold by McLachlan, Michael J., Chockalingam, Karuppiah, Lai, Ka Chun, Zhao, Huimin

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