Search Results - "McLachlan, Alan"

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection by Wooddell, Christine I, Rozema, David B, Hossbach, Markus, John, Matthias, Hamilton, Holly L, Chu, Qili, Hegge, Julia O, Klein, Jason J, Wakefield, Darren H, Oropeza, Claudia E, Deckert, Jochen, Roehl, Ingo, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Vornlocher, Hans-Peter, McLachlan, Alan, Lewis, David L

“…RNA interference (RNAi)-based therapeutics have the potential to treat chronic hepatitis B virus (HBV) infection in a fundamentally different manner than…”
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Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease by Kallwitz, Eric R, McLachlan, Alan, Cotler, Scott J

“…Nonalcoholic fatty liver disease （NAFLD） is highly prevalent and can result in nonalcoholic steatohepatitis （NASH） and progressive liver disease including…”
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Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis by Taha, Taha Y, Anirudhan, Varada, Limothai, Umaporn, Loeb, Daniel D, Petukhov, Pavel A, McLachlan, Alan, Luo, Guangxiang George, Guo, Haitao

“…Hepatitis B virus (HBV) is a worldwide health problem without curative treatments. Investigation of the regulation of HBV biosynthesis by class I and II…”
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Independent Activation of Hepatitis B Virus Biosynthesis by Retinoids, Peroxisome Proliferators, and Bile Acids by Reese, Vanessa C, Oropeza, Claudia E, McLachlan, Alan

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Role of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in AKT/PKB-Mediated Inhibition of Hepatitis B Virus Biosynthesis by ONDRACEK, Caitlin R, MCLACHLAN, Alan

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Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism by Tang, Hong, McLachlan, Alan

“…Hepatotropism is a prominent feature of hepatitis B virus (HBV) infection. Cell lines of nonhepatic origin do not independently support HBV replication. Here,…”
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Transcriptional Regulation of Hepatitis B Virus by Nuclear Hormone Receptors is a Critical Determinant of Viral Tropism by Tang, Hong, McLachlan, Alan

“…Hepatotropism is a prominent feature of hepatitis B virus (HBV) infection. Cell lines of nonhepatic origin do not independently support HBV replication. Here,…”
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Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation by McFadden, Vanessa C, Shalaby, Rasha E, Iram, Saira, Oropeza, Claudia E, Landolfi, Jennifer A, Lyubimov, Alexander V, Maienschein-Cline, Mark, Green, Stefan J, Kaestner, Klaus H, McLachlan, Alan

“…The FoxA family of pioneer transcription factors regulates hepatitis B virus (HBV) transcription, and hence viral replication. Hepatocyte-specific…”
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Limited Effects of Bile Acids and Small Heterodimer Partner on Hepatitis B Virus Biosynthesis In Vivo by REESE, Vanessa C, MOORE, David D, MCLACHLAN, Alan

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Differential Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by the Small Heterodimer Partner by OROPEZA, Claudia E, LIE LI, MCLACHLAN, Alan

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Limited Effects of Fasting on Hepatitis B Virus (HBV) Biosynthesis in HBV Transgenic Mice by LIE LI, OROPEZA, Claudia E, KAESTNER, Klaus H, MCLACHLAN, Alan

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Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and Small Heterodimer Partner Differentially Regulate Nuclear Receptor-Dependent Hepatitis B Virus Biosynthesis by ONDRACEK, Caitlin R, RUSHING, Christel N, REESE, Vanessa C, OROPEZA, Claudia E, MCLACHLAN, Alan

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β-Catenin Signaling Regulates the In Vivo Distribution of Hepatitis B Virus Biosynthesis across the Liver Lobule by Tarnow, Grant, McLachlan, Alan

“…β-Catenin (Ctnnb1) supports high levels of liver gene expression in hepatocytes in proximity to the central vein functionally defining zone 3 of the liver…”
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Distinct Regulation of Hepatitis B Virus Biosynthesis by Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and Small Heterodimer Partner in Human Hepatoma Cell Lines by ONDRACEK, Caitlin R, REESE, Vanessa C, RUSHING, Christel N, OROPEZA, Claudia E, MCLACHLAN, Alan

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Selective effect of β-catenin on nuclear receptor-dependent hepatitis B virus transcription and replication by Tarnow, Grant, McLachlan, Alan

“…β-catenin regulates HBV transcription in cell culture and viral biosynthesis in vivo in the transgenic mouse model of chronic HBV infection. Therefore, it is…”
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β by Tang, Hong, McLachlan, Alan

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Nuclear Covalently Closed Circular Viral Genomic DNA in the Liver of Hepatocyte Nuclear Factor 1α-Null Hepatitis B Virus Transgenic Mice by Raney, A K, Eggers, C M, Kline, E F, Guidotti, L G, Pontoglio, M, Yaniv, M, McLachlan, A

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Alpha/Beta Interferon Differentially Modulates the Clearance of Cytoplasmic Encapsidated Replication Intermediates and Nuclear Covalently Closed Circular Hepatitis B Virus (HBV) DNA from the Livers of Hepatocyte Nuclear Factor 1α-Null HBV Transgenic Mice by ANDERSON, Aimee L, BANKS, Krista E, PONTOGLIO, Marco, YANIV, Moshe, MCLACHLAN, Alan

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Avian and Mammalian Hepadnaviruses Have Distinct Transcription Factor Requirements for Viral Replication by Tang, Hong, McLachlan, Alan

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Replication of the Wild Type and a Natural Hepatitis B Virus Nucleocapsid Promoter Variant Is Differentially Regulated by Nuclear Hormone Receptors in Cell Culture by Tang, H, Raney, A K, McLachlan, A

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